Identification and characterization of a novel Apical Membrane Antigen 3 in Eimeria tenella

2020 ◽  
Author(s):  
Qingjie Wang ◽  
Shunhai Zhu ◽  
Qiping Zhao ◽  
Bing Huang ◽  
Shuilan Yu ◽  
...  
Keyword(s):  
Apical Membrane ◽  
Eimeria Tenella ◽  
Apical Membrane Antigen ◽  
Identification And Characterization

scholarly journals Identification and Characterization of Eimeria tenella Apical Membrane Antigen-1 (AMA1)

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41115 ◽  
Author(s):  
Lianlian Jiang ◽  
Jiaojiao Lin ◽  
Hongyu Han ◽  
Hui Dong ◽  
Qiping Zhao ◽  
...  
Keyword(s):  
Apical Membrane ◽  
Eimeria Tenella ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen ◽  
Identification And Characterization

Screening and characterization of apical membrane antigen 1 interacting proteins in Eimeria tenella

2016 ◽  
Vol 170 ◽  
pp. 116-124 ◽  
Author(s):  
Hongyu Han ◽  
Pu Xue ◽  
Hui Dong ◽  
Shunhai Zhu ◽  
Qiping Zhao ◽  
...  
Keyword(s):  
Apical Membrane ◽  
Eimeria Tenella ◽  
Interacting Proteins ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen

scholarly journals Further investigation of the characteristics and biological function of Eimeria tenella apical membrane antigen 1

Parasite ◽  
2020 ◽  
Vol 27 ◽  
pp. 70
Author(s):  
Qingjie Wang ◽  
Qiping Zhao ◽  
Shunhai Zhu ◽  
Bing Huang ◽  
Shuilan Yu ◽  
...  
Keyword(s):  
Rna Binding ◽  
Apical Membrane ◽  
Mapk Signaling ◽  
Eimeria Tenella ◽  
Host Cells ◽  
Differentially Expressed ◽  
Type I ◽  
Dependent Manner ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen

Apical membrane antigen 1 (AMA1) is a type I integral membrane protein that is highly conserved in apicomplexan parasites. Previous studies have shown that Eimeria tenella AMA1 (EtAMA1) is critical for sporozoite invasion of host cells. Here, we show that EtAMA1 is a microneme protein secreted by sporozoites, confirming previous results. Individual and combined treatment with antibodies of EtAMA1 and its interacting proteins, E. tenella rhoptry neck protein 2 (EtRON2) and Eimeria-specific protein (EtESP), elicited significant anti-invasion effects on the parasite in a concentration-dependent manner. The overexpression of EtAMA1 in DF-1 cells showed a significant increase of sporozoite invasion. Isobaric tags for relative and absolute quantitation (iTRAQ) coupled with LC-MS/MS were used to screen differentially expressed proteins (DEPs) in DF-1 cells transiently transfected with EtAMA1. In total, 3953 distinct nonredundant proteins were identified and 163 of these were found to be differentially expressed, including 91 upregulated proteins and 72 downregulated proteins. The DEPs were mainly localized within the cytoplasm and were involved in protein binding and poly(A)-RNA binding. KEEG analyses suggested that the key pathways that the DEPs belonged to included melanogenesis, spliceosomes, tight junctions, and the FoxO and MAPK signaling pathways. The data in this study not only provide a comprehensive dataset for the overall protein changes caused by EtAMA1 expression, but also shed light on EtAMA1’s potential molecular mechanisms during Eimeria infections.

scholarly journals Characterization of a novel inhibitory human monoclonal antibody directed against Plasmodium falciparum Apical Membrane Antigen 1

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Dominika J. Maskus ◽  
Michał Królik ◽  
Susanne Bethke ◽  
Holger Spiegel ◽  
Stephanie Kapelski ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Plasmodium Falciparum ◽  
Apical Membrane ◽  
Human Monoclonal Antibody ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen

Characterization of the Apical Membrane Antigen-1 in Italian Strains of Babesia bigemina

2010 ◽  
Vol 57 (1-2) ◽  
pp. 52-56 ◽  
Author(s):  
A. Torina ◽  
A. Agnone ◽  
G. Sireci ◽  
J. J. Mosqueda ◽  
V. Blanda ◽  
...  
Keyword(s):  
Apical Membrane ◽  
Babesia Bigemina ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

2016 ◽  
Vol 29 (6) ◽  
pp. 281-291 ◽  
Author(s):  
Bankala Krishnarjuna ◽  
San Sui Lim ◽  
Shane M. Devine ◽  
Cael O. Debono ◽  
Raymond Lam ◽  
...  
Keyword(s):  
Small Molecule ◽  
Apical Membrane ◽  
Solution Nmr ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen ◽  
Nmr Characterization ◽  
Molecule Interactions

Identification and characterization of a cathepsin-L-like peptidase in Eimeria tenella

2014 ◽  
Vol 113 (12) ◽  
pp. 4335-4348 ◽  
Author(s):  
Renqiang Liu ◽  
Xueting Ma ◽  
Aijun Liu ◽  
Lei Zhang ◽  
Jianping Cai ◽  
...  
Keyword(s):  
Cathepsin L ◽  
Eimeria Tenella ◽  
Identification And Characterization

scholarly journals Structural Characterization of Apical Membrane Antigen 1 (AMA1) from Toxoplasma gondii

2010 ◽  
Vol 285 (20) ◽  
pp. 15644-15652 ◽  
Author(s):  
Joanna Crawford ◽  
Michelle L. Tonkin ◽  
Ognjen Grujic ◽  
Martin J. Boulanger
Keyword(s):  
Toxoplasma Gondii ◽  
Structural Characterization ◽  
Apical Membrane ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen
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