scholarly journals Effect of Vascular Risk Factors and Diseases on Mortality in Individuals with Dementia: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 64 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Irene E. van de Vorst ◽  
Huiberdina L. Koek ◽  
Rehana de Vries ◽  
Michiel L. Bots ◽  
Johannes B. Reitsma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Vascular Risk Factors ◽  
Vascular Risk

scholarly journals Aerobic exercise interventions reduce blood pressure in patients after stroke or transient ischaemic attack: a systematic review and meta-analysis

2018 ◽  
Vol 53 (24) ◽  
pp. 1515-1525 ◽  
Author(s):  
Cheng Wang ◽  
Jessica Redgrave ◽  
Mohsen Shafizadeh ◽  
Arshad Majid ◽  
Karen Kilner ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Blood Pressure ◽  
Transient Ischaemic Attack ◽  
Meta Analysis ◽  
Vascular Risk Factors ◽  
Cochrane Library ◽  
Vascular Risk ◽  
Exercise Interventions ◽  
Ischaemic Attack

ObjectiveSecondary vascular risk reduction is critical to preventing recurrent stroke. We aimed to evaluate the effect of exercise interventions on vascular risk factors and recurrent ischaemic events after stroke or transient ischaemic attack (TIA).DesignIntervention systematic review and meta-analysis.Data sourcesOVID MEDLINE, PubMed, The Cochrane Library, Web of Science, The National Institute for Health and Care Excellence, TRIP Database, CINAHL, PsycINFO, SCOPUS, UK Clinical Trials Gateway and the China National Knowledge Infrastructure were searched from 1966 to October 2017.Eligibility criteriaRandomised controlled trials evaluating aerobic or resistance exercise interventions on vascular risk factors and recurrent ischaemic events among patients with stroke or TIA, compared with control.ResultsTwenty studies (n=1031) were included. Exercise interventions resulted in significant reductions in systolic blood pressure (SBP) −4.30 mm Hg (95% CI −6.77 to −1.83) and diastolic blood pressure −2.58 mm Hg (95% CI −4.7 to −0.46) compared with control. Reduction in SBP was most pronounced among studies initiating exercise within 6 months of stroke or TIA (−8.46 mm Hg, 95% CI −12.18 to −4.75 vs −2.33 mm Hg, 95% CI −3.94 to −0.72), and in those incorporating an educational component (−7.81 mm Hg, 95% CI −14.34 to −1.28 vs −2.78 mm Hg, 95% CI −4.33 to −1.23). Exercise was also associated with reductions in total cholesterol (−0.27 mmol/L, 95% CI −0.54 to 0.00), but not fasting glucose or body mass index. One trial reported reductions in secondary vascular events with exercise, but was insufficiently powered.SummaryExercise interventions can result in clinically meaningful blood pressure reductions, particularly if initiated early and alongside education.

Midlife Vascular Risk Factors and the Risk of Alzheimer's Disease: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 42 (4) ◽  
pp. 1295-1310 ◽  
Author(s):  
Xiang-Fei Meng ◽  
Jin-Tai Yu ◽  
Hui-Fu Wang ◽  
Meng-Shan Tan ◽  
Chong Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Vascular Risk Factors ◽  
Vascular Risk

Ticagrelor for stroke prevention in patients with vascular risk factors: A systematic review and meta-analysis

2018 ◽  
Vol 390 ◽  
pp. 212-218 ◽  
Author(s):  
Konark Malhotra ◽  
Nitin Goyal ◽  
Alissa S. Kasunich ◽  
Sunil A. Sheth ◽  
Aristeidis H. Katsanos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Stroke Prevention ◽  
Meta Analysis ◽  
Vascular Risk Factors ◽  
Vascular Risk

HIV, Vascular Risk Factors, and Cognition in the Combination Antiretroviral Therapy Era: A Systematic Review and Meta-Analysis

2020 ◽  
pp. 1-17
Author(s):  
Elissa C. McIntosh ◽  
Kayla Tureson ◽  
Lindsay J. Rotblatt ◽  
Elyse J. Singer ◽  
April D. Thames
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Antiretroviral Therapy ◽  
Cognitive Dysfunction ◽  
Meta Analysis ◽  
Neurocognitive Impairment ◽  
Vascular Risk Factors ◽  
People Living With Hiv ◽  
Vascular Risk ◽  
Combination Antiretroviral Therapy

Abstract Objectives: Mounting evidence indicates that vascular risk factors (VRFs) are elevated in HIV and play a significant role in the development and persistence of HIV-associated neurocognitive disorder. Given the increased longevity of people living with HIV (PLWH), there is a great need to better elucidate vascular contributions to neurocognitive impairment in HIV. This systematic review and meta-analysis examine relationships between traditional VRFs, cardiovascular disease (CVD), and cognition in PLWH in the combination antiretroviral therapy era. Methods: For the systematic review, 44 studies met inclusion criteria and included data from 14,376 PLWH and 6,043 HIV-seronegative controls. To better quantify the contribution of VRFs to cognitive impairment in HIV, a robust variance estimation meta-analysis (N = 11 studies) was performed and included data from 2139 PLWH. Results: In the systematic review, cross-sectional and longitudinal studies supported relationships between VRFs, cognitive dysfunction, and decline, particularly in the domains of attention/processing speed, executive functioning, and fine motor skills. The meta-analysis demonstrated VRFs were associated with increased odds of global neurocognitive impairment (odds ratio [OR ]= 2.059, p = .010), which remained significant after adjustment for clinical HIV variables (p = .017). Analyses of individual VRFs demonstrated type 2 diabetes (p = .004), hyperlipidemia (p = .043), current smoking (p = .037), and previous CVD (p = .0005) were significantly associated with global neurocognitive impairment. Conclusions: VRFs and CVD are associated with worse cognitive performance and decline, and neurocognitive impairment in PLWH. Future studies are needed to examine these relationships in older adults with HIV, and investigate how race/ethnicity, gender, medical comorbidities, and psychosocial factors contribute to VRF-associated cognitive dysfunction in HIV.

The influence of vascular risk factors on cognitive decline in patients with dementia: A systematic review

Maturitas ◽  
2013 ◽  
Vol 76 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Kim Blom ◽  
Mariëlle H. Emmelot-Vonk ◽  
Huiberdina (Dineke) L. Koek
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Cognitive Decline ◽  
Vascular Risk Factors ◽  
Vascular Risk
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