Clinical Outcomes Associated with Medication Regimen Complexity in Older People: A Systematic Review

2016 ◽  
Vol 65 (4) ◽  
pp. 747-753 ◽  
Author(s):  
Barbara C Wimmer ◽  
Amanda J Cross ◽  
Natali Jokanovic ◽  
Michael D Wiese ◽  
Johnson George ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older People ◽  
Clinical Outcomes ◽  
Medication Regimen ◽  
Medication Regimen Complexity ◽  
Regimen Complexity

Are Clinical Outcomes Associated With Medication Regimen Complexity? A Systematic Review and Meta-analysis

2019 ◽  
Vol 54 (4) ◽  
pp. 301-313 ◽  
Author(s):  
Vanessa Alves-Conceição ◽  
Kérilin Stancine Santos Rocha ◽  
Fernanda Vilanova Nascimento Silva ◽  
Rafaella de Oliveira Santos Silva ◽  
Sabrina Cerqueira-Santos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Case Control ◽  
Current Evidence ◽  
Medication Regimen ◽  
Medication Regimen Complexity ◽  
Complexity Index ◽  
Regimen Complexity

Background: Current evidence of the influence of the medication regimen complexity (MRC) on the patients’ clinical outcomes are not conclusive. Objective: To systematically and analytically assess the association between MRC measured by the Medication Regimen Complexity Index (MRCI) and clinical outcomes. Methods: A search was carried out in the databases Cochrane Library, LILACS, PubMed, Scopus, EMBASE, Open Thesis, and Web of Science to identify studies evaluating the association between MRC and clinical outcomes that were published from January 1, 2004, to April 2, 2018. The search terms included outcome assessment, drug therapy, and medication regimen complexity index and their synonyms in different combinations for case-control and cohort studies that used the MRCI to measure MRC and related the MRCI with clinical outcomes. Odds ratios (ORs), hazard ratios (HRs), and mean differences (WMDs) were calculated, and heterogeneity was assessed using the I2 test. Results: A total of 12 studies met the eligibility criteria. The meta-analysis showed that MRC is associated with the following clinical outcomes: hospitalization (HR = 1.20; 95% CI = 1.14 to 1.27; I2 = 0%) in cohort studies, hospital readmissions (WMD = 7.72; 95% CI = 1.19 to 14.25; I2 = 84%) in case-control studies, and medication nonadherence (adjusted OR = 1.05; 95% CI = 1.02 to 1.07; I2 = 0%) in cohort studies. Conclusion and Relevance: This systematic review and meta-analysis gathered relevant scientific evidence and quantified the combined estimates to show the association of MRC with clinical outcomes: hospitalization, hospital readmission, and medication adherence.

Association between medication regimen complexity and pharmacotherapy adherence: a systematic review

2017 ◽  
Vol 73 (11) ◽  
pp. 1475-1489 ◽  
Author(s):  
Laís Lessa Pantuzza ◽  
Maria das Graças Braga Ceccato ◽  
Micheline Rosa Silveira ◽  
Luane Mendes Ribeiro Junqueira ◽  
Adriano Max Moreira Reis
Keyword(s):  
Systematic Review ◽  
Medication Regimen ◽  
Medication Regimen Complexity ◽  
Regimen Complexity

Medication Regimen Complexity and Unplanned Hospital Readmissions in Older People

2014 ◽  
Vol 48 (9) ◽  
pp. 1120-1128 ◽  
Author(s):  
Barbara C. Wimmer ◽  
Elsa Dent ◽  
J. Simon Bell ◽  
Michael D. Wiese ◽  
Ian Chapman ◽  
...  
Keyword(s):  
Older People ◽  
Hospital Readmissions ◽  
Medication Regimen ◽  
Medication Regimen Complexity ◽  
Regimen Complexity

scholarly journals Complexity of pharmacotherapeutic regimens for older adults in primary care in Brazil: a cross-sectional study

2021 ◽  
Author(s):  
Mariana Carvalho Bilac ◽  
Luiz Santana Passos ◽  
Romana Santos Gama ◽  
Renato Morais Souza ◽  
Welma Wildes Amorim ◽  
...  
Keyword(s):  
Primary Care ◽  
Older People ◽  
Care Setting ◽  
Primary Care Setting ◽  
Cross Sectional Study ◽  
Medication Regimen ◽  
Cross Sectional ◽  
Medication Regimen Complexity ◽  
Complexity Index ◽  
Regimen Complexity

Aims: Adherence to prescribed treatment is important for obtaining the desired outcomes in older people care. Polypharmacy is strictly associated with adherence, and complex pharmacotherapy can lead to poor adherence and unexpected outcomes, which are aggravated by older age. The medication regimen complexity index has been proven to be a valid and reliable tool for quantifying the complexity of medication regimens. The objective of the present study was to evaluate the therapeutic complexity of drugs used by older people in a primary care setting in Brazil. Methods: This was a cross-sectional study conducted in 22 basic health units in Brazil. Older people from this sample who were treated in a primary care setting were interviewed after a consultation with a family practice physician. Data were collected from September 2016 to March 2019. Patients aged ≥ 60 years who visited the primary care units were included in the study. Pharmacotherapeutic complexity was assessed according to the medication regimen complexity index. Results: In all, 675 individuals with a mean age of 70 years (±7.1 years) were included. The mean number of drugs prescribed per capita was 2.9 (±1.8). The median medication regimen complexity index for the sample was 8.0, and 26.1% of the patients interviewed had a high medication regimen complexity index. Conclusion: The complexity of the drug regimen was high in almost one-third of the prescriptions analysed. This high complexity might contribute to non-adherence to medication regimens, leading to safety- and effectiveness-related issues. Key words: drug prescriptions, geriatrics, pharmaceutical preparations, polypharmacy, primary health care, older patient.

Complexity perplexity: a systematic review to describe the measurement of medication regimen complexity

2013 ◽  
Vol 12 (6) ◽  
pp. 829-840 ◽  
Author(s):  
Allison M Paquin ◽  
Kristin M Zimmerman ◽  
Tia R Kostas ◽  
Lindsey Pelletier ◽  
Angela Hwang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Medication Regimen ◽  
Medication Regimen Complexity ◽  
Regimen Complexity

scholarly journals Medication Regimen Complexity and Polypharmacy as Factors Associated With All-Cause Mortality in Older People

2015 ◽  
Vol 50 (2) ◽  
pp. 89-95 ◽  
Author(s):  
Barbara C. Wimmer ◽  
J. Simon Bell ◽  
Johan Fastbom ◽  
Michael D. Wiese ◽  
Kristina Johnell
Keyword(s):  
Older People ◽  
Medication Regimen ◽  
Factors Associated ◽  
Medication Regimen Complexity ◽  
Regimen Complexity ◽  
All Cause Mortality
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