Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow’s feet, and collagen content: A double‐blind, randomized, placebo‐controlled trial

2020 ◽  
Vol 20 (1) ◽  
pp. 188-194
Author(s):  
Ping Lin ◽  
Ruth Audy Alexander ◽  
Chia‐Hua Liang ◽  
Cheng Liu ◽  
Yung‐Hao Lin ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Collagen Content ◽  
Skin Hydration ◽  
Double Blind ◽  
Crow’S Feet

scholarly journals The Effects of Skin Aging Associated with the Use of BioCell Collagen: A Randomized, Double-blind, Placebo-controlled Clinical Trial (P06-122-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Alexander Schauss ◽  
Stephen Schwartz ◽  
Kimberly Hammon ◽  
Anna Gafner Hardy ◽  
Norman Guttman ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Dietary Supplementation ◽  
Skin Surface ◽  
Skin Aging ◽  
Collagen Content ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Photographic Analysis ◽  
Crow’S Feet

Abstract Objectives The aim of the study intended to correlate the effects of the dietary supplement, BioCell Collagen, with any changes associated with skin aging, since dietary supplements claim cutaneous anti-aging properties for their products; however, research supporting these claims remains sparse. Methods A 12-week, randomized, double-blind, placebo-controlled trial of 128 female subjects, aged 39–59 (50.57 ± 5.55) randomly assigned to treatment or placebo. Intervention: Twice daily oral administration of a supplement containing 500 mg of a naturally occurring matrix of collagen type-II peptides, hyaluronic acid, and chondroitin sulfate, derived from chicken sternal cartilage, or placebo. Primary outcome measures: trans-epidermal water loss, viscoelasticity, hydration, collagen content, chromophore (melanin) content and hemoglobin level, and photographic analysis. Expert visual grading for facial lines/wrinkles, crow's feet lines/wrinkles, skin texture/smoothness, and skin tone. Secondary outcomes: Tolerance and incidence of adverse events. Presence of erythema and/or dryness determined tolerance. Participant's perception of the product's value. Results Dietary supplementation significantly reduced facial lines and wrinkles (p = 0.019), crow's feet lines/wrinkles (p = 0.05), increased skin elasticity (p = 0.05), cutaneous collagen content (p = 0.001), and improved indicators of youthful skin appearance and wrinkle width (p = 0.046), and decreased skin dryness and erythema, compared to placebo. There was no difference between supplement and placebo for skin surface water content or retention. Supplement was well tolerated with no reported adverse reactions. Conclusions Dietary supplementation of this chicken sternal cartilage extract supports the accumulation of types-I/III collagen in skin to promote increased elasticity and reduced skin wrinkling in women 39 to 59 years of age. Funding Sources BioCell Technology, LLC.

scholarly journals The Efficacy and Safety of Plant Oil Mixtures in the Treatment of Xerosis with Pruritus in Elderly People: Randomized double blind Controlled Trial

2020 ◽  
Vol 5 (3) ◽  
pp. 255-262
Author(s):  
Yulia Farida Yahya ◽  
Octyvani Vani ◽  
Dimas Ega Wijaya Putra ◽  
Cyntya Sari Sovianti ◽  
Damai Trislinawati ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Coconut Oil ◽  
Skin Hydration ◽  
Plant Oil ◽  
Double Blind ◽  
Co Morbidity ◽  
Geriatric Clinic ◽  
Oil Mixtures ◽  
Better Than

A B S T R A C TBackground: Xerosis skin and pruritus is the most commonly found in elderly withsymptoms mild to severe recurrent pruritus, the skin looks rough, scaly, fissured orcracked caused defects in the epidermal barrier function, increase co-morbidity aschronic infections and ulcers that are difficult to heal can decrease the quality of life.Virgin Coconut Oil (VCO) has been traditionally used for people in tropical regionas a moisturizer and anti-bacterial effect. In recent study that essential plant oilmixture have effect synergistically as anti inflammatory, anti pruritus, promotingwound healing may act promoting barrier skin and therapeutic. Objective: Efficacyand safety of plant oil mixtures as therapeutic and maintenance moisturizer.forXerosis and pruritus in elderly Method:A randomized controlled trial was involved61 elderly from nursing home and geriatric clinic in Moh. Hoesin General Hospital.They were randomized into 2 groups: plant oil mixtures (n=30) and Virgin Coconutoil (VCO) (n=31), applied on the volar legs twice a day for 4 weeks.Outcomes weremeasured at baseline and weekly, week 2 and 4.To measure of clinical dry scoreused ODSS; pruritus severity and side effect used VAS; for skin hydration usedcorneometer CM825and for sebum level used sebumeter SM 810. Results:Clinicaldry score, pruritus severity of plants oil mixtures group were significantly decreasedthan VCO at week 2 and 4 (p 0.000). Skin hydration and sebum level of plants oilmixture group were significantly increased than VCO at week 2 and 4 (p0.000).Clinical dry score, pruritus severity, skin hydration, andskin sebum levels ofplant oil mixtures were significantly better than VCO at week 4 (p 0.000). There isno side effects on both of plant oil mixtures and VCO groups Conclusion: Plant oilmixtures add pureCelin oil showed better efficacy as a therapeutin and maintanancemoisturizer for xerosis and pruritus in elderly. Both of plant oil mixtures and VCOcan be tolerated and safe to use.

scholarly journals SPECIFIC NATURAL BIOACTIVE TYPE 1 COLLAGEN PEPTIDES ORAL INTAKE REVERSE SKIN AGING SIGNS IN MATURE WOMEN

2016 ◽  
pp. 1-9
Author(s):  
L. Duteil ◽  
C. Queille-Roussel ◽  
Y. Maubert ◽  
J. Esdaile ◽  
C. Bruno-Bonnet ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Skin Aging ◽  
Skin Hydration ◽  
Type I ◽  
Double Blind ◽  
Crow’S Feet ◽  
Mature Women ◽  
Fish Collagen ◽  
Collagen Hydrolysates ◽  
Skin Biomechanics

Objective: To assess the anti-aging potential of three type I fish collagen hydrolysates (CH1=Naticol® BPMG, CH2=Naticol® HPMG, CH3=Naticol® 1000MG) on skin aging signs for three different body sites of mature women. Design: Double-blind, randomized and Placebo-controlled clinical study. Setting: Centre of Clinical Pharmacology Applied to Dermatology (CPCAD, Nice). Participants: Sixty women aged 46-69 years having skin aging signs on the face. Intervention: Participants were randomized to receive a once daily 5g dose of one of the CHs or Placebo for 8 weeks. Measurements: Skin biomechanics, skin hydration and visual assessment of the crow’s-feet wrinkles were evaluated after 4 and 8 weeks of treatment. Subject satisfaction questionnaire and Investigator global efficacy appreciation (IGEA) were also used. Results: Skin biomechanics indicated a significant improvement of skin firmness for the three CHs compared to Placebo, in particular for CH2. An increase of overall skin elasticity for CH3 (p = 0.017) and CH2 (p = 0.044) on the abdomen was also observed. This was corroborated by the significant decrease of the crow’s-feet wrinkle score at week 8 for both CH3 and CH2 (p=0.023 and p=0.014, respectively). Concerning the self-questionnaire, overall the number of positive responses was significantly higher for CH2 compared to Placebo and other CHs. For the IGEA, the number of favorable answers was greater for CH2 than for the Placebo group (80% vs. 36%, p= 0.025). A positive influence of CH treatments could be observed for skin hydration but failed to reach statistical significance. Conclusion: The tested type I fish collagen hydrolysates have beneficial effects on skin quality. In particular, CH2 demonstrated the greatest range of these effects including improvement of skin biomechanics, decrease of wrinkles, good subject satisfaction and no related adverse events.

scholarly journals Oral intake of heat-killed cells of Lactococcus lactis strain H61 promotes skin health in women

2012 ◽  
Vol 1 ◽  
Author(s):  
Hiromi Kimoto-Nira ◽  
Reiji Aoki ◽  
Keisuke Sasaki ◽  
Chise Suzuki ◽  
Koko Mizumachi
Keyword(s):  
Placebo Group ◽  
Environmental Change ◽  
Lactococcus Lactis ◽  
Controlled Trial ◽  
Oral Intake ◽  
Hair Follicles ◽  
Skin Hydration ◽  
Ageing Population ◽  
Skin Elasticity ◽  
Double Blind

AbstractWe conducted a double-blind, placebo-controlled trial to evaluate the effect of heat-killed cells of Lactococcus lactis strain H61 on various skin properties of Japanese women. Volunteers (age 31–62 years) were randomly assigned to receive test food with or without 60 mg of heat-killed strain H61 (fifteen women in each group; H61 and control groups, respectively) daily for 8 weeks. Results were analysed for three age categories (30s, 40s and 50–60s). Compared with that at week 0, skin hydration at the inner forearm at weeks 4 and 8 decreased in all volunteers (except those in their 50–60s) because of the environmental change from autumn to winter. The oldest H61 group maintained skin hydration at the inner forearm throughout the study. Skin elasticity and melanin content in the cheek decreased and sebum content increased throughout the test period due to seasonal environmental change, regardless of age or H61 treatment. Self-evaluation scores for apparent hair follicles and dryness of the throat at week 8 were higher in the overall H61 group than in the combined placebo group. The 30s H61 group noted marked improvements in self-surveyed skin elasticity at week 8 compared with at week 0 and with the placebo group at week 8. The results of the present study indicate that oral intake of heat-killed cells of L. lactis strain H61 can improve some skin properties and body characteristics in women. This strain would probably be useful in increasing the quality of life in an ageing population.

scholarly journals The Efficacy and Safety of Plant Oil Mixtures in the Treatment of Xerosis with Pruritus in Elderly People: Randomized double blind Controlled Trial

2020 ◽  
Vol 5 (1) ◽  
pp. 188-195
Author(s):  
Octyvani Vani ◽  
Nuri Rifiati ◽  
Yulia Farida Yahya ◽  
Dimas Ega Wijaya Putra ◽  
Cyntya Sari Sovianti ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Coconut Oil ◽  
Skin Hydration ◽  
Plant Oil ◽  
Double Blind ◽  
Co Morbidity ◽  
Geriatric Clinic ◽  
Oil Mixtures ◽  
Better Than

A B S T R A C TBackground: Xerosis skin and pruritus is the most commonly found in elderly withsymptoms mild to severe recurrent pruritus, the skin looks rough, scaly, fissured orcracked caused defects in the epidermal barrier function, increase co-morbidity aschronic infections and ulcers that are difficult to heal can decrease the quality of life.Virgin Coconut Oil (VCO) has been traditionally used for people in tropical regionas a moisturizer and anti-bacterial effect. In recent study that essential plant oilmixture have effect synergistically as anti inflammatory, anti pruritus, promotingwound healing may act promoting barrier skin and therapeutic. Objective: Efficacyand safety of plant oil mixtures as therapeutic and maintenance moisturizer.forXerosis and pruritus in elderly Method:A randomized controlled trial was involved61 elderly from nursing home and geriatric clinic in Moh. Hoesin General Hospital.They were randomized into 2 groups: plant oil mixtures (n=30) and Virgin Coconutoil (VCO) (n=31), applied on the volar legs twice a day for 4 weeks.Outcomes weremeasured at baseline and weekly, week 2 and 4.To measure of clinical dry scoreused ODSS; pruritus severity and side effect used VAS; for skin hydration usedcorneometer CM825and for sebum level used sebumeter SM 810. Results:Clinicaldry score, pruritus severity of plants oil mixtures group were significantly decreasedthan VCO at week 2 and 4 (p 0.000). Skin hydration and sebum level of plants oilmixture group were significantly increased than VCO at week 2 and 4 (p0.000).Clinical dry score, pruritus severity, skin hydration, andskin sebum levels ofplant oil mixtures were significantly better than VCO at week 4 (p 0.000). There isno side effects on both of plant oil mixtures and VCO groups Conclusion: Plant oilmixtures add pureCelin oil showed better efficacy as a therapeutin and maintanancemoisturizer for xerosis and pruritus in elderly. Both of plant oil mixtures and VCOcan be tolerated and safe to use.

Clinical efficacy of specific immunotherapy to cat dander: a double-blind placebo-controlled trial

1997 ◽  
Vol 27 (8) ◽  
pp. 860-867 ◽  
Author(s):  
V.A. VARNEY ◽  
J. EDWARDS ◽  
K. TABBAH ◽  
H. BREWSTER ◽  
G. MAVROLEON ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Specific Immunotherapy ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo

Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial

2001 ◽  
Vol 26 (1) ◽  
pp. 67-71 ◽  
Author(s):  
S. A. Ahmadi-Abhari ◽  
S. Akhondzadeh ◽  
S. M. Assadi ◽  
O. L. Shabestari ◽  
Z. M. Farzanehgan ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Side Effects ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled

A randomized double blind, placebo controlled trial of a Chinese herbal preparation (CH100) in chronic Hepatitis C

2001 ◽  
Vol 120 (5) ◽  
pp. A384-A384
Author(s):  
L MOLLISON ◽  
L TOTTEN ◽  
C HOVELL ◽  
K THAYNE ◽  
C CONNELLY ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Controlled Trial ◽  
Herbal Preparation ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Chinese Herbal
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