scholarly journals Microneedling‐assisted topical tranexamic acid solution versus 4% hydroquinone for treating melasma: A split‐face randomized study

2021 ◽  
Author(s):  
Mohamed S. Zaky ◽  
Zakaria M. Obaid ◽  
Eman A. Khalil ◽  
Mohamed L. Elsaie
Keyword(s):  
Tranexamic Acid ◽  
Acid Solution ◽  
Randomized Study ◽  
Solution Versus ◽  
Topical Tranexamic Acid ◽  
Split Face

scholarly journals Microneedling-Assisted Topical Tranexamic Acid Solution versus 4% Hydroquinone for Treating Melasma: A Split-Face randomized study

2021 ◽  
Author(s):  
Mohamed Zaky ◽  
Zakaria Obaid ◽  
Eman Khalil ◽  
Mohamed L. Elsaie
Keyword(s):  
Tranexamic Acid ◽  
Random Number ◽  
Randomized Study ◽  
Solution Versus ◽  
Safety And Efficacy ◽  
The Past ◽  
The Mean ◽  
Group B ◽  
Topical Tranexamic Acid ◽  
Split Face

Background Melasma, also known as chloasma or mask of pregnancy, is a common, acquired, hyperpigmentary disorder usually affecting females. Tranexamic acid (TA), a derivative of amino acid lysine has shown promising results over the past few years when used along with other therapies as well as when used as a stand-alone therapy. Aim of the Work In this study, we aimed to evaluate and compare the effectiveness of topically applied tranexamic acid after microneedling versus topically applied hydroquinone 4% alone in patients with melasma. Patients and Methods Fifty selected patients were divided randomly according to the random number allocation method into two groups (25 patients each) of A (topical 4% hydroquinone, nightly application) and B (microneedling + topical 4% TA, every other week). Results After Eight weeks of treatment, the mean modified MASI score of the HQ treated side changed from 6.604±4.02 to 3.032±1.19 with a mean decrease percentage of 54.8%±19.4%. This reduction in modified MASI score was found to be statistically significant, (p<0.001). MASI score of group B (TA + microneedling) changed from 6.348±3.84 to 3.712±1.19 with mean decrease percentage of 57.4%±23.4% which was also statistically significant, (p<0.001). Conclusion We demonstrated safety and efficacy of both used modalities and with minimal side effects. Topical HQ application achieved minimal non significant higher satisfactory results among raters and subjects

Topical tranexamic acid in cemented primary total knee arthroplasty without tourniquet: a prospective randomized study

2020 ◽  
Vol 30 (6) ◽  
pp. 1003-1008 ◽  
Author(s):  
Manuel Morales Santias ◽  
Jesus Mas Martinez ◽  
Javier Sanz-Reig ◽  
Enrique Martínez Gimenez ◽  
Carmen Verdu Román ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Randomized Study ◽  
Primary Total Knee Arthroplasty ◽  
Prospective Randomized Study ◽  
Total Knee ◽  
Without Tourniquet ◽  
Topical Tranexamic Acid ◽  
Primary Total Knee

scholarly journals The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty

2017 ◽  
Vol 25 (1) ◽  
pp. 230949901668472 ◽  
Author(s):  
Deniz Cankaya ◽  
Uygar Dasar ◽  
Ahmet Burak Satilmis ◽  
Serdar Hakan Basaran ◽  
Mustafa Akkaya ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Low Cost ◽  
Randomized Study ◽  
Topical Administration ◽  
Combined Use ◽  
Administration Method ◽  
Total Knee ◽  
Operative Drainage ◽  
Topical Tranexamic Acid

Aims: The combined (IV (intravenous) + topical) use of tranexamic acid (TXA) has been shown to be a safe method and more effective than single (IV or topical) application. The optimal administration method of TXA is still being investigated and safety, efficiency and cost are the three main crucial parameters in achieving the best administration method. We aimed to determine whether combined (oral + topical) use of TXA reduced blood loss and transfusion rates more than single (topical) administration in TKA and whether oral + topical use is as safe and efficient as the IV + topical use, in addition to the main advantage of relatively low cost. Methods: In this prospective, randomized study, 100 patients were randomly assigned to either the topical TXA group or the combined (oral + topical) TXA group. There were no significant differences between the groups in age, body mass index or gender. The haemoglobin and haematocrit levels of each patient were recorded preoperatively and on post-operative days 0, 1, 2 and 3. The post-operative suction drainage and blood transfusion volumes were also recorded. Results: There were statistically significant differences between the groups in haemoglobin and haematocrit levels on post-operative days 0, 1, 2 and 3 ( p < 0.05) in favour of the combined group. The post-operative drainage amounts ( p = 0.0001), measured blood loss volume ( p = 0.003) and transfusion rates ( p = 0.03) were lower in the combined (oral + topical) group compared to the topical group. Conclusions: Of the different methods of TXA administration, the combined use of oral and topical TXA is a safe, efficient and low-cost method in reducing blood loss and transfusion rates after TKA.

Comparison of Intravenous versus Topical Tranexamic Acid in Total Knee Arthroplasty: A Prospective Randomized Study

2014 ◽  
Vol 29 (8) ◽  
pp. 1528-1531 ◽  
Author(s):  
Jay N. Patel ◽  
Jonathon M. Spanyer ◽  
Langan S. Smith ◽  
Jiapeng Huang ◽  
Madhusudhan R. Yakkanti ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Randomized Study ◽  
Prospective Randomized Study ◽  
Total Knee ◽  
Topical Tranexamic Acid

The efficacy in treatment of facial melasma with thulium 1927-nm fractional laser-assisted topical tranexamic acid delivery: a split-face, double-blind, randomized controlled pilot study

2020 ◽  
Vol 35 (9) ◽  
pp. 2015-2021 ◽  
Author(s):  
Rungsima Wanitphakdeedecha ◽  
Francesca Sy-Alvarado ◽  
Poramin Patthamalai ◽  
Thanya Techapichetvanich ◽  
Sasima Eimpunth ◽  
...  
Keyword(s):  
Pilot Study ◽  
Tranexamic Acid ◽  
Fractional Laser ◽  
Double Blind ◽  
Randomized Controlled ◽  
Topical Tranexamic Acid ◽  
Split Face

Topical Tranexamic Acid Use in Knee Periprosthetic Joint Infection Is Safe and Effective

2015 ◽  
Vol 29 (05) ◽  
pp. 423-429 ◽  
Author(s):  
Talal Zahoor ◽  
Mark Meyer ◽  
Lock Ochsner ◽  
George Chimento ◽  
Bradford Waddell
Keyword(s):  
Tranexamic Acid ◽  
Periprosthetic Joint Infection ◽  
Joint Infection ◽  
Topical Tranexamic Acid

Topical tranexamic acid in spinal surgery: A systematic review and meta-analysis

2019 ◽  
Vol 61 ◽  
pp. 114-119 ◽  
Author(s):  
Ketan Yerneni ◽  
John F. Burke ◽  
Alexander Tuchman ◽  
Xudong J. Li ◽  
Lionel N. Metz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Tranexamic Acid ◽  
Spinal Surgery ◽  
Meta Analysis ◽  
Topical Tranexamic Acid

Matched cohort study of topical tranexamic acid in cementless primary total hip replacement

2018 ◽  
Vol 28 (7) ◽  
pp. 1335-1339 ◽  
Author(s):  
Javier Sanz-Reig ◽  
Jesus Mas Martinez ◽  
Carmen Verdu Román ◽  
Manuel Morales Santias ◽  
Enrique Martínez Gimenez ◽  
...  
Keyword(s):  
Cohort Study ◽  
Tranexamic Acid ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
Matched Cohort ◽  
Total Hip ◽  
Matched Cohort Study ◽  
Topical Tranexamic Acid

scholarly journals Hot Off the Press: Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs

2018 ◽  
Vol 25 (9) ◽  
pp. 1062-1064 ◽  
Author(s):  
Justin Morgenstern ◽  
Sahaana Rangarajan ◽  
Corey Heitz ◽  
Chris Bond ◽  
William K. Milne
Keyword(s):  
Tranexamic Acid ◽  
Nasal Packing ◽  
Antiplatelet Drugs ◽  
The Press ◽  
Topical Tranexamic Acid
Sign in / Sign up

Export Citation Format

Share Document