Sensitivity and Reproducibility of Fast-FLAIR, FSE, and TGSE Sequences for the MRI Assessment of Brain Lesion Load in Multiple Sclerosis: A Preliminary Study

The aim was to assess brain lesion load and anatomical distribution in patients with juvenile clinically isolated syndrome and define magnetic resonance imaging (MRI) variables associated with rapidly advancing to multiple sclerosis. Patients were followed for one year after disease onset. Patients who experienced a second relapse were defined as those who rapidly advanced to multiple sclerosis. In all, 46 juvenile patients with a clinical presentation suggestive of multiple sclerosis were evaluated; 21 with gadolinium-enhancing lesions on initial brain MRI were excluded as they had already fulfilled the diagnosis criteria for multiple sclerosis. A total of 25 patients, 10 males and 15 females (mean ± SE age at onset 15.6 ± 0.6 years), met the definition of clinically isolated syndrome. The presence of a corpus callosum lesion at onset significantly differentiated between sustained clinically isolated syndrome and patients who rapidly advanced to multiple sclerosis.

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Longitudinal evaluation of depression and anxiety in patients with clinically isolated syndrome at high risk of developing early multiple sclerosis

Multiple Sclerosis Journal ◽

10.1191/1352458503ms921oa ◽

2003 ◽

Vol 9 (3) ◽

pp. 302-306 ◽

Cited By ~ 39

Author(s):

S Di Legge ◽

M C Piattella ◽

C Pozzilli ◽

P Pantano ◽

F Caramia ◽

...

Keyword(s):

Multiple Sclerosis ◽

Depressive Symptoms ◽

Brain Lesion ◽

Clinically Isolated Syndrome ◽

Temporal Region ◽

Clinical Relapse ◽

Depression And Anxiety ◽

Lesion Load ◽

Mri Scans ◽

The Right

We investigated the relationship between emotional changes, brain lesion burden and development of multiple sclerosis (MS). Thirty-seven consecutive patients with clinically isolated syndrome (C IS) were prospectively assessed with the Expanded Disability Status Scale (EDSS), the 21-item Beck Depression Inventory (BDI), the State-Trait A nxiety Inventory (STAI) and gadolinium enhanced (Gd+) MRI scans. BDI and STAI were also administered to 36 age-matched controls. C onversion to MS was defined as the occurrence of a clinical relapse. C IS patients were more likely to endorse symptoms of anxiety and depression than controls. Baseline scores for depression and anxiety did not correlate with the total lesion load (i.e., volume of Gd+, T2 and T1 lesions) and the number of Gd+ lesions during the first six months of follow-up. A positive correlation was found between severity of depressive scores and the lesion load in the right temporal region (P =0.005). After 339-6 months of the study entry, patients who had a clinical relapse were more frequently depressed (P =0.001) than those relapse free. Emotional disturbances are frequently observed in C IS patients and show a tendency towards a normalization in relapse-free patients. The increased rate of depressive symptoms observed in patients who developed MS seems to result from a combination of psychological and organic features. The lesion load in the right temporal region is confirmed as a key area for developing depressive symptoms, even in the early phase of the disease.

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Faculty Opinions recommendation of Clinical correlations of brain lesion distribution in multiple sclerosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158633.618843 ◽

2009 ◽

Author(s):

Nancy Richert ◽

Francesca Bagnato

Keyword(s):

Multiple Sclerosis ◽

Brain Lesion ◽

Clinical Correlations

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Faculty Opinions recommendation of Texture analysis differentiates persistent and transient T1 black holes at acute onset in multiple sclerosis: a preliminary study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.8671962.9181063 ◽

2011 ◽

Author(s):

Nancy Richert ◽

Francesca Bagnato

Keyword(s):

Multiple Sclerosis ◽

Black Holes ◽

Texture Analysis ◽

Acute Onset ◽

Preliminary Study

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CSF proteome in multiple sclerosis subtypes related to brain lesion transcriptomes

Scientific Reports ◽

10.1038/s41598-021-83591-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Maria L. Elkjaer ◽

Arkadiusz Nawrocki ◽

Tim Kacprowski ◽

Pernille Lassen ◽

Anja Hviid Simonsen ◽

...

Keyword(s):

Multiple Sclerosis ◽

Protein Phosphatase ◽

Brain Lesion ◽

Brain Lesions ◽

Cns Diseases ◽

Secondary Progressive ◽

Apolipoprotein A ◽

Proteomic Approach ◽

Apolipoprotein C ◽

Altered Proteins

AbstractTo identify markers in the CSF of multiple sclerosis (MS) subtypes, we used a two-step proteomic approach: (i) Discovery proteomics compared 169 pooled CSF from MS subtypes and inflammatory/degenerative CNS diseases (NMO spectrum and Alzheimer disease) and healthy controls. (ii) Next, 299 proteins selected by comprehensive statistics were quantified in 170 individual CSF samples. (iii) Genes of the identified proteins were also screened among transcripts in 73 MS brain lesions compared to 25 control brains. F-test based feature selection resulted in 8 proteins differentiating the MS subtypes, and secondary progressive (SP)MS was the most different also from controls. Genes of 7 out these 8 proteins were present in MS brain lesions: GOLM was significantly differentially expressed in active, chronic active, inactive and remyelinating lesions, FRZB in active and chronic active lesions, and SELENBP1 in inactive lesions. Volcano maps of normalized proteins in the different disease groups also indicated the highest amount of altered proteins in SPMS. Apolipoprotein C-I, apolipoprotein A-II, augurin, receptor-type tyrosine-protein phosphatase gamma, and trypsin-1 were upregulated in the CSF of MS subtypes compared to controls. This CSF profile and associated brain lesion spectrum highlight non-inflammatory mechanisms in differentiating CNS diseases and MS subtypes and the uniqueness of SPMS.

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