Faculty Opinions recommendation of Texture analysis differentiates persistent and transient T1 black holes at acute onset in multiple sclerosis: a preliminary study.

2011 ◽  
Author(s):  
Nancy Richert ◽  
Francesca Bagnato
Keyword(s):  
Multiple Sclerosis ◽  
Black Holes ◽  
Texture Analysis ◽  
Acute Onset ◽  
Preliminary Study

Texture analysis differentiates persistent and transient T1 black holes at acute onset in multiple sclerosis: A preliminary study

2011 ◽  
Vol 17 (5) ◽  
pp. 532-540 ◽  
Author(s):  
Yunyan Zhang ◽  
Anthony Traboulsee ◽  
Yinshan Zhao ◽  
Luanne M Metz ◽  
David K Li
Keyword(s):  
Multiple Sclerosis ◽  
Black Holes ◽  
Texture Analysis ◽  
Tissue Damage ◽  
Tissue Injury ◽  
Lesion Size ◽  
Acute Onset ◽  
Coarse Texture ◽  
Preliminary Study ◽  
Stockwell Transform

Background and Objective: The persistence of new enhancing T1 hypointense lesions (acute black holes, ABHs) in multiple sclerosis (MS) cannot be predicted visually at lesion onset. Texture analysis using the polar Stockwell transform (PST) applied to conventional MR images however shows promise in quantifying tissue injury early. The objective of this study was to explore whether ABHs that persist (pABHs) differ from those that are transient (tABHs) using PST texture analysis. Methods: Fifteen ABHs (8 pABHs; 7 tABHs) from 9 patients were analyzed on 3T images obtained during a clinical trial. Persistence was defined as remaining T1 hypointense 5–8 months later. NAWM regions were examined to control for changes unrelated to ABHs. Results: At first appearance, there was higher coarse texture indicating greater tissue damage in the pABHs than in the tABHs ( p < 0.01). Both had greater coarse texture than the contralateral and general NAWM ( p ≤ 0.01). No difference was identified in normalized signal intensity between pABHs and tABHs and neither demonstrated location preference. While tABHs tended to be smaller than pABHs there was no correlation between lesion size and texture (r = 0.44, p > 0.05). Furthermore, coarse texture content appeared to predict persistence of individual lesions. Conclusions: This preliminary study suggests that PST texture could predict persistence of tissue injury based on the severity of structural disorganization within acute lesions. While confirmation of this data is required texture analysis may prove to be a valuable tool to quantify tissue damage and predict recovery in proof-of-concept neuroprotection and repair trials.

scholarly journals Initial Neurologic Symptoms Among Bangladeshi Multiple Sclerosis Patients

1970 ◽  
Vol 24 (1) ◽  
pp. 9-16
Author(s):  
Md Bahadur Ali Miah ◽  
Abdul Kader Sheikh ◽  
Akhlaque Hosain Khan ◽  
Md Rafiqul Islam ◽  
AKM Anwar Ullah ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Acute Onset ◽  
Motor Weakness ◽  
Neurologic Symptoms ◽  
Data Collection Sheet ◽  
Tonic Spasm ◽  
Male Patients ◽  
Restricted Activity ◽  
Multiple Sclerosis Patients ◽  
Medical University

This study was undertaken in the Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from January 2002 to December 2003. The objective of this study was to determine the initial neurologic symptoms of multiple sclerosis among Bangladeshi patients. A total of 25 respondents of multiple sclerosis patients as cases selected by McDonald et al. (2001) diagnostic criteria for multiple sclerosis were enlisted during the study period. The clinical details, investigations of the respondents were reviewed. Data were recorded in predesigned data collection sheet. Out of 25 cases, male patients were 12 (48%) and females were 13 (52%), ratio being 1:1.08. Majority of the patients presented at second, third and fourth decades of life. Most of the patients (56%) had acute onset, followed by subacute (28%) and insidious (16%). Certain clinical characteristics among Bangladeshi multiple sclerosis patients are noteworthy, namely, number of male and female patients almost equal (48% vs 52%), a higher rate of impaired vision (optic nerve involvement, 64%), motor weakness (92%), sphincteric disturbances (92%) and a lower rate of brainstem and cerebellar involvement. Painful tonic spasm was a prominent feature among Bangladeshi patients with multiple sclerosis (8 out of 25, 32%). Out of 25 patients, one (4%) expired due to aspiration pneumonia. Twenty four (96%) survived. Among them 9 (36%) has restricted activity, 7 (28%) were bedridden, 5 (20%) were chairbound, 2 (8%) had minor disability and were in work and 1 (4%) was completely normal. DOI: http://dx.doi.org/10.3329/bjn.v24i1.3035 Bangladesh Journal of Neuroscience 2008; Vol. 24 (1) :9-16

scholarly journals Effects of Interferon Beta-1b on Black Holes in Multiple Sclerosis Over a 6-Year Period With Monthly Evaluations

2005 ◽  
Vol 62 (11) ◽  
pp. 1684 ◽  
Author(s):  
Francesca Bagnato ◽  
Shiva Gupta ◽  
Nancy D. Richert ◽  
Roger D. Stone ◽  
Joan M. Ohayon ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Black Holes ◽  
Interferon Beta

Lesion-to-ventricle distance and other risk factors for the persistence of newly formed black holes in relapsing–remitting multiple sclerosis

2013 ◽  
Vol 20 (3) ◽  
pp. 322-330 ◽  
Author(s):  
Athina Papadopoulou ◽  
Milena Menegola ◽  
Jens Kuhle ◽  
Sreeram V Ramagopalan ◽  
Marcus D’Souza ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Black Holes ◽  
Subventricular Zone ◽  
Magnetic Resonance Images ◽  
Lateral Ventricles ◽  
Relapsing Remitting ◽  
Specific Factors ◽  
One Year ◽  
Relapsing Remitting Multiple Sclerosis ◽  
The Relationship

Background: Progenitor cells from the subventricular zone (SVZ) of the lateral ventricles are assumed to contribute to remyelination and resolution of black holes (BHs) in multiple sclerosis (MS). This process may depend on the distance between the lesion and the SVZ. Objective: The objective of this paper is to investigate the relationship between lesion-to-ventricle (LV) distance and persistence of new BHs. Methods: We analysed the magnetic resonance images (MRIs) of 289 relapsing–remitting (RR) MS patients, obtained during a multi-centre, placebo-controlled phase II trial over one year. Results: Overall, 112/289 patients showed 367 new BHs at the beginning of the trial. Of these, 225 were located in 94/112 patients at the level of the lateral ventricles on axial MRIs and included in this analysis. In total, 86/225 (38%) BHs persisted at month 12. LV distance in persistent BHs (PBHs) was not longer than in transient BHs. In fact PBHs tended to be closer to the SVZ than transient BHs. A generalised linear mixed multivariate model adjusted for BHs clustered within a patient and including patient- as well as lesion-specific factors revealed size, ring contrast enhancement, and shorter LV distance as independent predictors for BH persistence. Conclusion: Location of BHs close to the lateral ventricles does not appear to favourably influence the resolution of new BHs in RRMS.

scholarly journals Relationship between Physical Disability and Black Holes in Multiple Sclerosis: Upper Extremity Functions - an Important Parameter

2021 ◽  
Vol 1 (1) ◽  
pp. 17-21
Author(s):  
Bilge Piri Cinar ◽  
Gülcan Kalaycı ◽  
Mustafa Acikgoz ◽  
Serkan Ozakbas
Keyword(s):  
Multiple Sclerosis ◽  
Black Holes ◽  
Upper Extremity ◽  
Physical Disability

Paroxysmal kinesigenic dyskinesia–like phenotype in multiple sclerosis

2017 ◽  
Vol 23 (13) ◽  
pp. 1795-1797 ◽  
Author(s):  
Roxana Pop ◽  
Stefan Kipfer
Keyword(s):  
Multiple Sclerosis ◽  
Gene Mutations ◽  
Brain Magnetic Resonance Imaging ◽  
Acute Onset ◽  
Intravenous Steroid ◽  
Paroxysmal Kinesigenic Dyskinesia ◽  
Hyperkinetic Movement Disorder ◽  
Magnetic Resonance Imaging Mri ◽  
The Right ◽  
Rapid Regression

In April 2015, a 20-year-old woman with multiple sclerosis (MS) presented with acute onset of repetitive abnormal postures and choreatic movements of the right arm, precipitated by voluntary movements (online video 1 and 2). Brain magnetic resonance imaging (MRI) showed a new active MS lesion involving the basal ganglia on the left side (Figure 1(a)). Intravenous steroid treatment resulted in rapid regression of this paroxysmal kinesigenic dyskinesia (PKD)-like hyperkinetic movement disorder. The patient became asymptomatic within 3 months. PKD is characterized by recurrent uni- or bilateral choreoathetosis and usually represents an autosomal dominant inherited disorder caused by PRRT2 gene mutations. As in the present case, a PKD-like phenotype may be associated with MS relapses in presumably genetic negative cases.

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