Christian Loret De Mola
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Giovanny Vinícius Araújo De França
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Luciana de Avila Quevedo
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Bernardo Lessa Horta
BackgroundThere is no consensus on the effects that low birth weight, premature
birth and intrauterine growth have on later depression.AimsTo review systematically the evidence on the relationship of low birth
weight, smallness for gestational age (SGA) and premature birth with
adult depression.MethodWe searched the literature for original studies assessing the effect of
low birth weight, premature birth and SGA on adult depression. Separate
meta-analyses were carried out for each exposure using random and fixed
effects models. We evaluated the contribution of methodological
covariates to heterogeneity using meta-regression.ResultsWe identified 14 studies evaluating low birth weight, 9 premature birth
and 4 SGA. Low birth weight increased the odds of depression (OR = 1.39,
95% CI 1.21–1.60). Premature birth and SGA were not associated with
depression, but publication bias might have underestimated the effect of
the former and only four studies evaluated SGA.ConclusionsLow birth weight was associated with depression. Future studies
evaluating premature birth and SGA are needed.