Decision letter for "RNA In‐situ Hybridisation for Human Papillomavirus Testing in Oropharyngeal Squamous Cell Carcinoma on a Routine Clinical Diagnostic Platform"

2020 ◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
In Situ Hybridisation ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Human Papillomavirus Testing ◽  
Clinical Diagnostic

scholarly journals Human Papillomavirus Testing in Head and Neck Squamous Cell Carcinoma: Impact of the 2018 College of American Pathologists Guideline Among Referral Cases at a Large Academic Institution

2020 ◽  
Author(s):  
Donna C Ferguson ◽  
Mitra Mehrad ◽  
Kim A Ely ◽  
Justin R Shinn ◽  
James S. Lewis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Neck Squamous Cell Carcinoma ◽  
Human Papillomavirus Testing ◽  
P16 Immunohistochemistry ◽  
The Impact

Context.— Given the growing clinical significance of human papillomavirus status in oropharyngeal squamous cell carcinoma, the College of American Pathologists established a set of evidence-based recommendations for high-risk human papillomavirus testing. Objective.— To evaluate the impact of the recommendations on human papillomavirus ancillary test ordering habits by comparing compliance before and after the guideline was published. Design.— We retrospectively reviewed head and neck squamous cell carcinoma biopsy or resection specimens from outside institutions during a 2.5-year period around guideline publication for whether or not human papillomavirus testing was performed in accordance with the guideline. Results.— Human papillomavirus testing deviated from the guideline in 45 of 107 cases (42.1%) before and 93 of 258 cases (36.0%) after their publication (P = .29). This included 6 of 26 cases of oropharyngeal squamous cell carcinoma (23.1%) before and 5 of 55 cases (9.1%) after (P = .16), with 5 of 5 (100.0%) after due to not performing p16 immunohistochemistry. This also included 30 of 68 cases of nonoropharyngeal carcinoma (44.1%) before and 69 of 163 (42.3%) after the guideline was published (P = .88), with 29 of 30 (96.7%) before and 67 of 69 (97.1%) after due to unnecessary use of p16 immunohistochemistry. Nodal metastasis testing deviated in 9 of 13 cases (69.2%) before and 19 of 40 cases (47.5%) after (P = .21) with marked variability in testing, including 3 of 9 (33.3%) before and 8 of 19 (42.1%) after, for not confirming certain p16 immunohistochemistry–positive tumors with human papillomavirus–specific testing. Conclusions.— Pathologists continue to deviate from the testing guideline significantly in everyday practice. Further education and discussion about the appropriate handling of head and neck cancer specimens may be needed.

Pre-treatment absolute lymphocyte count predicts for improved survival in human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma

Oral Oncology ◽  
2021 ◽  
Vol 116 ◽  
pp. 105245
Author(s):  
P.J. Kreinbrink ◽  
J. Li ◽  
S. Parajuli ◽  
T.M. Wise-Draper ◽  
D.L. Choi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphocyte Count ◽  
Absolute Lymphocyte Count ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Pre Treatment

Transoral robotic surgery for oropharyngeal squamous cell carcinoma in the era of human papillomavirus

Head & Neck ◽  
2017 ◽  
Vol 40 (4) ◽  
pp. 710-721 ◽  
Author(s):  
Omar Mahmoud ◽  
Kim Sung ◽  
Francisco J. Civantos ◽  
Giovanna R. Thomas ◽  
Michael A. Samuels
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Robotic Surgery ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transoral Robotic Surgery ◽  
Oropharyngeal Squamous Cell Carcinoma

Treatment trends for advanced oropharyngeal squamous cell carcinoma in the era of human papillomavirus

Head & Neck ◽  
2021 ◽  
Author(s):  
Faris A. Mirza ◽  
Christopher Z. Johnson ◽  
James Kenneth Byrd ◽  
William Greer Albergotti
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Treatment Trends

Survival Outcomes for p16-positive Oropharyngeal Squamous Cell Carcinoma Based on Human Papillomavirus Status

2021 ◽  
Author(s):  
S.D. Robinson ◽  
J.D. Towler ◽  
R. Kitson ◽  
D. Saleh ◽  
H.-C. Younan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Survival Outcomes

Impact of Human Papillomavirus on the Tumor Microenvironment in Oropharyngeal Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Xinyi Liu ◽  
Ping Liu ◽  
Rebecca D. Chernock ◽  
Krystle A. Lang Kuhs ◽  
James S. Lewis ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma
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