scholarly journals Effect of combination of hydrophilic and lipophilic permeation enhancers on the skin permeation of kahalalide F

2014 ◽  
Vol 66 (6) ◽  
pp. 760-768 ◽  
Author(s):  
Punit P. Shah ◽  
Pinaki R. Desai ◽  
Ram Patlolla ◽  
Larry Klevans ◽  
Mandip Singh
Keyword(s):  
Skin Permeation ◽  
Permeation Enhancers ◽  
Kahalalide F

Chemical Permeation Enhancers for Transdermal Delivery of Thiocolchicoside: Assessment of Ex-vivo Skin Flux and In-vivo Pharmacokinetics

2017 ◽  
Vol 10 (5) ◽  
pp. 3827-3835
Author(s):  
Y Madhusudan Rao ◽  
Gayatri P ◽  
Ajitha M ◽  
P. Pavan Kumar ◽  
Kiran kumar
Keyword(s):  
Passive Control ◽  
Ex Vivo ◽  
Skin Permeation ◽  
In Vivo Studies ◽  
Permeation Enhancers ◽  
Casting Technique ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation ◽  
In Vivo Pharmacokinetics

Present investigation comprises the study of ex-vivo skin flux and in-vivo pharmacokinetics of Thiocolchicoside (THC) from transdermal films. The films were fabricated by solvent casting technique employing combination of hydrophilic and hydrophobic polymers. A flux of 18.08 µg/cm2h and 13.37µg/cm2h was achieved for optimized formulations containing 1, 8-cineole and oleic acid respectively as permeation enhancers. The observed flux values were higher when compared to passive control (8.66 µg/cm2h). Highest skin permeation was observed when 1,8-cineole was used as chemical permeation enhancer and it considerably (2-2.5 fold) improved the THC transport across the rat skin. In vivo studies were performed in rabbits and samples were analysed by LC-MS-MS. The mean area under the curve (AUC) values of transdermal film showed about 2.35 times statistically significant (p<0.05) improvement in bioavailability when compared with the oral administration of THC solution. The developed transdermal therapeutic systems using chemical permeation enhancers were suitable for drugs like THC in effective management of muscular pain.    

Rat epidermal keratinocyte organotypic culture (ROC) compared to human cadaver skin: The effect of skin permeation enhancers

2007 ◽  
Vol 30 (3-4) ◽  
pp. 240-250 ◽  
Author(s):  
Sari Pappinen ◽  
Sanna Tikkinen ◽  
Sanna Pasonen-Seppänen ◽  
Lasse Murtomäki ◽  
Marjukka Suhonen ◽  
...  
Keyword(s):  
Organotypic Culture ◽  
Skin Permeation ◽  
Human Cadaver ◽  
Permeation Enhancers ◽  
Epidermal Keratinocyte ◽  
Human Cadaver Skin ◽  
Cadaver Skin

Novel skin permeation enhancers based on amino acid ester ionic liquid: Design and permeation mechanism

2020 ◽  
Vol 576 ◽  
pp. 119031 ◽  
Author(s):  
Luyao Zheng ◽  
Zhiyuan Zhao ◽  
Ye Yang ◽  
Yaming Li ◽  
Chengxiao Wang
Keyword(s):  
Ionic Liquid ◽  
Amino Acid ◽  
Acid Ester ◽  
Skin Permeation ◽  
Amino Acid Ester ◽  
Permeation Enhancers

Effects of Adhesives and Permeation Enhancers on the Skin Permeation of Captopril

2001 ◽  
Vol 27 (9) ◽  
pp. 975-980 ◽  
Author(s):  
Eun-Seok Park ◽  
Seok-Jung Chang ◽  
Yun-Seok Rhee ◽  
Sang-Cheol Chi
Keyword(s):  
Skin Permeation ◽  
Permeation Enhancers

Influence of skin permeation enhancers on the transdermal delivery of palonosetron: An in vitro evaluation

2018 ◽  
Vol 16 (3) ◽  
pp. 192-197 ◽  
Author(s):  
Anroop B. Nair ◽  
Shery Jacob ◽  
Bandar E. Al-Dhubiab ◽  
Rakan Naser Alhumam
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
Permeation Enhancers ◽  
In Vitro Evaluation

Ionic liquids as solubility/permeation enhancers for topical formulations: Skin permeation and cytotoxicity characterization

2015 ◽  
Vol 238 (2) ◽  
pp. S293 ◽  
Author(s):  
T. Santos de Almeida ◽  
A. Júlio ◽  
R. Caparica ◽  
C. Rosado ◽  
A.S. Fernandes ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Skin Permeation ◽  
Permeation Enhancers ◽  
Topical Formulations ◽  
As Solubility

Simple alkyl esters as skin permeation enhancers

1989 ◽  
Vol 9 (1) ◽  
pp. 33-41 ◽  
Author(s):  
David Friend ◽  
Paul Catz ◽  
Jorge Heller
Keyword(s):  
Skin Permeation ◽  
Alkyl Esters ◽  
Permeation Enhancers
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