scholarly journals Altered red blood cell deformability—A novel hypothesis for retinal microangiopathy in diabetic retinopathy

2020 ◽  
Vol 27 (7) ◽  
Author(s):  
Justin Kok Soon Tan ◽  
Xin Wei ◽  
Peter Agustinus Wong ◽  
Jie Fang ◽  
Sangho Kim ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

F292. Red blood cell deformability in diabetic retinopathy

Biorheology ◽  
1995 ◽  
Vol 32 (2-3) ◽  
pp. 389-389 ◽  
Author(s):  
I TESTA ◽  
S MANFRINI ◽  
F GREGORIO ◽  
A REFE ◽  
A BONFIGLI ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

Red Blood Cell Deformability Index in Diabetic Retinopathy

1987 ◽  
Vol 19 (11) ◽  
pp. 569-573 ◽  
Author(s):  
E. Diamantopoulos ◽  
S. Raptis ◽  
S. Moulopoulos
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

A study of red blood cell deformability in diabetic retinopathy using optical tweezers

2015 ◽  
Author(s):  
Thomas J. Smart ◽  
Christopher J. Richards ◽  
Rhythm Bhatnagar ◽  
Carlos Pavesio ◽  
Rupesh Agrawal ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Cell ◽  
Optical Tweezers ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

scholarly journals Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Rupesh Agrawal ◽  
Thomas Smart ◽  
João Nobre-Cardoso ◽  
Christopher Richards ◽  
Rhythm Bhatnagar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Blood Cell ◽  
Optical Tweezers ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

scholarly journals Multiplexed fluidic plunger mechanism for the measurement of red blood cell deformability

Lab on a Chip ◽  
2015 ◽  
Vol 15 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Marie-Eve Myrand-Lapierre ◽  
Xiaoyan Deng ◽  
Richard R. Ang ◽  
Kerryn Matthews ◽  
Aline T. Santoso ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Heterogeneous Sample ◽  
Red Blood Cell Deformability

Mechanism for multiplexed measurement of single red blood cell deformability to evaluate pathological cells in a heterogeneous sample.

Effects of Pentoxifylline and Metabolite on Red Blood Cell Deformability as Measured by Ektacytometry

Angiology ◽  
1990 ◽  
Vol 41 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Doyle M. Cummings ◽  
Samir K. Ballas
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

Limited effects of activated protein C on red blood cell deformability

2013 ◽  
Vol 53 (4) ◽  
pp. 387-391 ◽  
Author(s):  
Michael Piagnerelli ◽  
Hassane Njimi ◽  
Tatiana Veloso Coelho ◽  
Giulia Reggiori ◽  
Diego Castanares Zapatero ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Protein C ◽  
Activated Protein C ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

Susceptibility of density-fractionated erythrocytes to subhaemolytic mechanical shear stress

2018 ◽  
Vol 42 (3) ◽  
pp. 151-157 ◽  
Author(s):  
Antony P McNamee ◽  
Kieran Richardson ◽  
Jarod Horobin ◽  
Lennart Kuck ◽  
Michael J Simmonds
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Shear Stresses ◽  
Mechanical Stimuli ◽  
Cell Deformability ◽  
Red Blood Cell Deformability ◽  
Cell Age ◽  
Low Shear

Introduction: Accumulating evidence demonstrates that subhaemolytic mechanical stresses, typical of circulatory support, induce physical and biochemical changes to red blood cells. It remains unclear, however, whether cell age affects susceptibility to these mechanical forces. This study thus examined the sensitivity of density-fractionated red blood cells to sublethal mechanical stresses. Methods: Red blood cells were isolated and washed twice, with the least and most dense fractions being obtained following centrifugation (1500 g × 5 min). Red blood cell deformability was determined across an osmotic gradient and a range of shear stresses (0.3–50 Pa). Cell deformability was also quantified before and after 300 s exposure to shear stresses known to decrease (64 Pa) or increase (10 Pa) red blood cell deformability. The time course of accumulated sublethal damage that occurred during exposure to 64 Pa was also examined. Results: Dense red blood cells exhibited decreased capacity to deform when compared with less dense cells. Cellular response to mechanical stimuli was similar in trend for all red blood cells, independent of density; however, the magnitude of impairment in cell deformability was exacerbated in dense cells. Moreover, the rate of impairment in cellular deformability, induced by 64 Pa, was more rapid for dense cells. Relative improvement in red blood cell deformability, due to low-shear conditioning (10 Pa), was consistent for both cell populations. Conclusion: Red blood cell populations respond differently to mechanical stimuli: older (more dense) cells are highly susceptible to sublethal mechanical trauma, while cell age (density) does not appear to alter the magnitude of improved cell deformability following low-shear conditioning.

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