Deep Brain Stimulation‐Related Surgical Site Infections: A Systematic Review and Meta‐Analysis

2021 ◽  
Vol 24 (2) ◽  
pp. 197-211
Author(s):  
Maria Kantzanou ◽  
Stefanos Korfias ◽  
Ioannis Panourias ◽  
Damianos E. Sakas ◽  
Maria A. Karalexi
Keyword(s):  
Systematic Review ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Surgical Site Infections ◽  
Deep Brain

Deep brain stimulation for multiple sclerosis tremor: A systematic review and meta-analysis

2021 ◽  
Vol 56 ◽  
pp. 103256
Author(s):  
Alireza Zali ◽  
Reza Jalili Khoshnood ◽  
Mahsa Motavaf ◽  
Alireza Salimi ◽  
Meisam Akhlaghdoust ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Deep Brain

A systematic review and meta-analysis of deep brain stimulation for depression

2018 ◽  
Vol 35 (5) ◽  
pp. 468-480 ◽  
Author(s):  
Steve Kisely ◽  
Amy Li ◽  
Nicola Warren ◽  
Dan Siskind
Keyword(s):  
Systematic Review ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Deep Brain

Use of Topical Vancomycin Powder to Reduce Surgical Site Infections after Deep Brain Stimulation Surgery: UCSF Experience and Meta-Analysis

2021 ◽  
pp. 1-10
Author(s):  
Sravani Kondapavulur ◽  
John F. Burke ◽  
Monica Volz ◽  
Doris D. Wang ◽  
Philip A. Starr
Keyword(s):  
Systematic Review ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Control Group ◽  
Inclusion Criteria ◽  
Vancomycin Powder ◽  
Group 3 ◽  
Deep Brain

<b><i>Objective:</i></b> Surgical site infection (SSI) is the most common serious complication of deep brain stimulation (DBS) implantation surgery. Here, we report a single-surgeon experience on the efficacy of topical, intrawound vancomycin powder (VP) in reducing SSI for DBS surgery and present the first systematic review and meta-analysis examining the effect of topical vancomycin on SSI in patients after DBS surgery. <b><i>Methods:</i></b> For the retrospective review, all unique patients undergoing DBS surgery at UCSF for new hardware implantation or internal pulse generator (IPG) replacement by a single surgeon from September 2013 to March 2019, with at least 1 year of follow-up data, were included. For the meta-analysis, we included all primary studies that compared SSIs with and without application of topical vancomycin in DBS surgeries. <b><i>Results:</i></b> 368 unique patients met inclusion criteria; 195 patients received topical VP (VP group) and 173 did not (control). 99/195 patients in the VP group underwent new DBS implantation and 96/195 had IPG replacement. 71/173 patients in the control group had new DBS implantation and 102/173 had IPG replacement. There were 10 total cases of SSI: 4 patients from the VP group (3 new implants and 1 IPG replacement) and 6 patients from the control group (3 new implants and 3 IPG replacements), resulting in SSI rates of 2.1 and 3.5%, respectively (<i>p</i> value = 0.337). Including our retrospective analysis, 6 studies met inclusion criteria for the systematic review and meta-analysis. In the 4 studies that examined primary DBS implants, 479 total patients received topical VP and 436 did not; mean odds ratio for SSI with topical vancomycin was 0.802 (95% confidence interval [CI] 0.175–3.678). Across the 5 studies that examined IPG implantations or replacements, 606 total patients received topical VP while 1,173 patients did not; mean odds ratio for SSI with topical vancomycin was 0.492 (95% CI 0.164–1.475). In either case, topical VP application did not significantly decrease risk of SSI. <b><i>Conclusion:</i></b> Surgical infections after DBS surgery are uncommon events, with studies demonstrating mixed results on whether topical vancomycin reduces this risk. Our single-institution retrospective analysis and systematic review of prior studies both demonstrated no significant SSI rate reduction with topical VP. This is likely due to low baseline SSI rates, resulting in a small effect size for prevention. Given the cost-effectiveness, simplicity, and low risk, topical, intrawound VP remains a treatment option to further reduce risk of SSI, particularly in settings with higher baseline infection rates.

scholarly journals Deep Brain Stimulation Versus Peripheral Denervation for Cervical Dystonia: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 122 ◽  
pp. e940-e946 ◽  
Author(s):  
Krishnan Ravindran ◽  
Nishant Ganesh Kumar ◽  
Dario J. Englot ◽  
Thomas J. Wilson ◽  
Scott L. Zuckerman
Keyword(s):  
Systematic Review ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Cervical Dystonia ◽  
Meta Analysis ◽  
Deep Brain

scholarly journals Deep brain stimulation effects on lower urinary tract function: Systematic review and meta-analysis

2020 ◽  
Vol 79 ◽  
pp. 65-72
Author(s):  
Elisa Jörg ◽  
Andrea M. Sartori ◽  
Anna-Sophie Hofer ◽  
Christian R. Baumann ◽  
Thomas M. Kessler
Keyword(s):  
Systematic Review ◽  
Urinary Tract ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Lower Urinary Tract ◽  
Meta Analysis ◽  
Lower Urinary Tract Function ◽  
Tract Function ◽  
Deep Brain ◽  
Lower Urinary

STN vs. GPi deep brain stimulation for tremor suppression in Parkinson disease: A systematic review and meta-analysis

2019 ◽  
Vol 58 ◽  
pp. 56-62 ◽  
Author(s):  
Joshua K. Wong ◽  
James H. Cauraugh ◽  
Kwo Wei David Ho ◽  
Matthew Broderick ◽  
Adolfo Ramirez-Zamora ◽  
...  
Keyword(s):  
Systematic Review ◽  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Tremor Suppression ◽  
Deep Brain

scholarly journals Effect of deep brain stimulation on impulse control behaviors of Parkinson’s disease patients: A systematic review and meta-analysis

2021 ◽  
Vol 26 ◽  
pp. 101361
Author(s):  
Ali Razmkon ◽  
Saeed Abdollahifard ◽  
Hirad Rezaei ◽  
Amir Reza Bahadori ◽  
Amirhossein Roshanshad ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Impulse Control ◽  
Meta Analysis ◽  
Deep Brain
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