scholarly journals “Response to Letter to the Editor Regarding: Managing Intrathecal Drug Delivery Devices in a Global Pandemic”: A Correction

2021 ◽  
Vol 24 (4) ◽  
pp. 799-799
Author(s):  
Andrew Purcell ◽  
David M. Moore
Keyword(s):  
Drug Delivery ◽  
Letter To The Editor ◽  
Intrathecal Drug Delivery ◽  
Global Pandemic ◽  
Drug Delivery Devices

scholarly journals Managing Intrathecal Drug Delivery Devices in a Global Pandemic

2020 ◽  
Vol 23 (5) ◽  
pp. 716-717 ◽  
Author(s):  
Philip Kim ◽  
Timothy Deer
Keyword(s):  
Drug Delivery ◽  
Intrathecal Drug Delivery ◽  
Global Pandemic ◽  
Drug Delivery Devices

scholarly journals Surgical Site Infections in Cancer Patients with Intrathecal Drug Delivery Devices: Table 1

Pain Medicine ◽  
2016 ◽  
pp. pnw203
Author(s):  
Maura M. Scanlon ◽  
Halena M. Gazelka ◽  
Susan M. Moeschler ◽  
Bryan C. Hoelzer ◽  
W. Michael Hooten ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Patients ◽  
Surgical Site Infections ◽  
Intrathecal Drug Delivery ◽  
Drug Delivery Devices

Dental Drug-Delivery Devices: Local and Sustained-Release Applications

1999 ◽  
Vol 16 (5) ◽  
pp. 36 ◽  
Author(s):  
Doron Steinberg ◽  
Michael Friedman
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery Devices

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

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