High‐resolution colonic manometry interobserver analysis trial

2021 ◽  
Author(s):  
Jasper Pannemans ◽  
Tim Vanuytsel ◽  
Ans Pauwels ◽  
Nathalie Rommel ◽  
Heiko De Schepper ◽  
...  
Keyword(s):  
High Resolution ◽  
Colonic Manometry

scholarly journals A35 ASSOCIATIONS BETWEEN AUTONOMIC DYSFUNCTION, COLONIC DYSMOTILITY AND ABSENT DEFECATION REFLEXES IN PATIENTS WITH CHRONIC REFRACTORY CONSTIPATION

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 276-278
Author(s):  
L Liu ◽  
N Milkova ◽  
M Ali ◽  
K Sharma ◽  
J D Huizinga ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
High Resolution ◽  
Autonomic Dysfunction ◽  
Sympathetic Tone ◽  
Stress Index ◽  
Autonomic Reactivity ◽  
Autonomic Tone ◽  
Autonomic Nervous ◽  
Colonic Manometry

Abstract Background A defecation reflex involves sensory information from the colon sent to the central nervous system which results in propulsive motor patterns in the colon through programmed neural activity from the autonomic nervous system. Neurological causes of constipation are recognized but specific neurological pathways that contribute to pathophysiology of the disease is underexplored. Diagnosis and treatment usually do not involve the autonomic nervous system. Aims Our objective was to assess autonomic dysfunction and abnormal defecation reflexes as a possible cause of chronic constipation. Methods Defecation reflexes were assessed by high-resolution colonic manometry through balloon distention, meal intake, and rectal bisacodyl. Specific heart rate variability (HRV) parameters were used to assess general orthostatic autonomic reactivity, and autonomic functioning during high resolution colonic manometry, in 14 patients with chronic refractory constipation considered for surgery. Results All patients had a unique combination of motility, reflex ability and HRV profiles. Patients overall did not generate HAPWs or had lower HAPW amplitude and lower propulsive activity compared to healthy individuals. Half of the 14 patients were tested to have high sympathetic tone based on Baevsky’s stress index prior to HRCM, and 11 of the patients had sympathetic hyper-reactivity and/or low parasympathetic reactivity to at least one type of colonic stimulation during HRCM. Abnormal autonomic tone or autonomic reactivity to colonic stimulation was present in all four patients with absence of the vagosacral defecation reflex. Five of the seven patients with absence of the sacral defecation reflex showed high sympathetic tone or high sympathetic reactivity to stimulation. Only two patients had abnormality in coloanal coordination and this was associated with low parasympathetic reactivity to stimulation in both patients. Conclusions The assumption that colonic resection was needed to remove an inert colon was wrong in most patients, but most patients had some form of reflex abnormality. Sympathetic dominance far outweighed parasympathetic dysfunction. Incorporation of assessments of defecation reflexes and autonomic nervous system activity into diagnosis of chronic refractory constipation provides a comprehensive pathophysiological understanding of specific defective neurological pathways contributing to dysmotility. This forms the basis for our individualized treatment efforts through sacral neuromodulation. Funding Agencies CIHR

scholarly journals The Defecation Reflex Assessed by High-Resolution Colonic Manometry

2020 ◽  
Author(s):  
Ji-Hong Chen ◽  
Natalija Milkova ◽  
Lijun Liu ◽  
Jan D Huizinga
Keyword(s):  
High Resolution ◽  
Colonic Manometry

scholarly journals A288 ANAL SPHINCTER RELAXATION ASSOCIATED WITH THE DEFECATION REFLEX AND GAS EXPULSION, ASSESSED BY HIGH-RESOLUTION COLONIC MANOMETRY

2018 ◽  
Vol 1 (suppl_2) ◽  
pp. 415-416
Author(s):  
J Chen ◽  
M Shokrollahi ◽  
E Ratcliffe ◽  
D Armstrong ◽  
S P Parsons ◽  
...  
Keyword(s):  
High Resolution ◽  
Anal Sphincter ◽  
Colonic Manometry

837 The Spatiotemporal Characteristics of Retrograde Motor Activity in the Distal Colon Defined by High-Resolution Colonic Manometry

2016 ◽  
Vol 150 (4) ◽  
pp. S177 ◽  
Author(s):  
Anthony Y. Lin ◽  
Peng Du ◽  
Jozef Kamp ◽  
Leo K. Cheng ◽  
Philip Dinning ◽  
...  
Keyword(s):  
High Resolution ◽  
Motor Activity ◽  
Distal Colon ◽  
Spatiotemporal Characteristics ◽  
Colonic Manometry

Development and feasibility of an ambulatory acquisition system for fiber‐optic high‐resolution colonic manometry

2019 ◽  
Vol 31 (12) ◽  
Author(s):  
Cameron I. Wells ◽  
Nira Paskaranandavadivel ◽  
Anthony Y. Lin ◽  
Peng Du ◽  
James A. Penfold ◽  
...  
Keyword(s):  
High Resolution ◽  
Fiber Optic ◽  
Acquisition System ◽  
Colonic Manometry

Su1591 Cross-Wavelet Transform for the Automated Analysis of High-Resolution Colonic Manometry Data

2016 ◽  
Vol 150 (4) ◽  
pp. S536
Author(s):  
Lukasz Wiklendt ◽  
Marcello Costa ◽  
Philip Dinning
Keyword(s):  
Wavelet Transform ◽  
High Resolution ◽  
Automated Analysis ◽  
Colonic Manometry ◽  
Cross Wavelet Transform ◽  
Cross Wavelet

scholarly journals Su1644 – Interobserver Analysis Trial on Colonic Motor Pattern Recognition for High-Resolution Colonic Manometry

2019 ◽  
Vol 156 (6) ◽  
pp. S-595
Author(s):  
Jasper Pannemans ◽  
Tim Vanuytsel ◽  
Ans Pauwels ◽  
Nathalie Rommel ◽  
Heiko U. De Schepper ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
High Resolution ◽  
Motor Pattern ◽  
Colonic Manometry ◽  
Colonic Motor

scholarly journals A296 A RHYTHMIC MOTOR PATTERN ASSOCIATED WITH HIGH AMPLITUDE PRESSURE WAVES IN HUMAN HIGH-RESOLUTION COLONIC MANOMETRY

2018 ◽  
Vol 1 (suppl_2) ◽  
pp. 425-426
Author(s):  
J Chen ◽  
M Pervez ◽  
E Ratcliffe ◽  
D Armstrong ◽  
P Bercik ◽  
...  
Keyword(s):  
High Resolution ◽  
Motor Pattern ◽  
High Amplitude ◽  
Pressure Waves ◽  
Rhythmic Motor ◽  
Colonic Manometry ◽  
Rhythmic Motor Pattern

Use of high-resolution colonic manometry to establish etiology and direct treatment in patients with constipation: Case series with correlation to histology

2018 ◽  
Vol 33 (11) ◽  
pp. 1864-1872 ◽  
Author(s):  
Yuwei Li ◽  
Jiying Cong ◽  
Fei Fei ◽  
Zhao Zhang ◽  
Yongjun Yu ◽  
...  
Keyword(s):  
High Resolution ◽  
Case Series ◽  
Direct Treatment ◽  
Colonic Manometry
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