Engineering of hairpin ribozyme variants for RNA recombination and splicing

2019 ◽  
Vol 1447 (1) ◽  
pp. 135-143 ◽  
Author(s):  
Robert Hieronymus ◽  
Sabine Müller
Keyword(s):  
Hairpin Ribozyme ◽  
Rna Recombination

Hairpin ribozyme mediated RNA recombination

2016 ◽  
Vol 52 (23) ◽  
pp. 4365-4368 ◽  
Author(s):  
Robert Hieronymus ◽  
Simon Peter Godehard ◽  
Darko Balke ◽  
Sabine Müller
Keyword(s):  
Hammerhead Ribozyme ◽  
Hairpin Ribozyme ◽  
Rna Recombination

An engineered hairpin ribozyme supports the recombination of two non-functional substrates into a functional hammerhead ribozyme.

Synthesis of uridine analogues to probe the functional group requirements of the hairpin ribozyme

1996 ◽  
Vol 61 (s1) ◽  
pp. 280-282 ◽  
Author(s):  
Joseph S. Vyle ◽  
Karen J. Young ◽  
Sarah Jones ◽  
Jane A. Grasby
Keyword(s):  
Functional Group ◽  
Hairpin Ribozyme

Functional group mutagenesis of the hairpin ribozyme

1999 ◽  
Author(s):  
Isabel K. McDonald ◽  
Stephen C. Holmes ◽  
Karen J. Young ◽  
Joseph S. Vyle ◽  
Timothy J. Pickering ◽  
...  
Keyword(s):  
Functional Group ◽  
Hairpin Ribozyme

scholarly journals Norovirus recombination

2007 ◽  
Vol 88 (12) ◽  
pp. 3347-3359 ◽  
Author(s):  
Rowena A. Bull ◽  
Mark M. Tanaka ◽  
Peter A. White
Keyword(s):  
High Frequency ◽  
Driving Force ◽  
Recombination Event ◽  
Viral Evolution ◽  
Rna Recombination ◽  
Recombination Point ◽  
The Family ◽  
Double Recombination ◽  
Double Recombination Event ◽  
Recombination Breakpoints

RNA recombination is a significant driving force in viral evolution. Increased awareness of recombination within the genus Norovirus of the family Calicivirus has led to a rise in the identification of norovirus (NoV) recombinants and they are now reported at high frequency. Currently, there is no classification system for recombinant NoVs and a widely accepted recombinant genotyping system is still needed. Consequently, there is duplication in reporting of novel recombinants. This has led to difficulties in defining the number and types of recombinants in circulation. In this study, 120 NoV nucleotide sequences were compiled from the current GenBank database and published literature. NoV recombinants and their recombination breakpoints were identified using three methods: phylogenetic analysis, SimPlot analysis and the maximum χ 2 method. A total of 20 NoV recombinant types were identified in circulation worldwide. The recombination point is the ORF1/2 overlap in all isolates except one, which demonstrated a double recombination event within the polymerase region.

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