Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics

Oral Diseases ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Shigeo Ishikawa ◽  
Masahiro Sugimoto ◽  
Kaoru Edamatsu ◽  
Ayako Sugano ◽  
Kenichiro Kitabatake ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals Recurrent chromosomal and epigenetic alterations in oral squamous cell carcinoma and its putative premalignant condition oral lichen planus

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0215055 ◽  
Author(s):  
Christopher G. Németh ◽  
Christoph Röcken ◽  
Reiner Siebert ◽  
Jörg Wiltfang ◽  
Ole Ammerpohl ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Oral Lichen Planus ◽  
Epigenetic Alterations ◽  
Premalignant Condition ◽  
Oral Lichen

Evaluation of MYC status in oral lichen planus in patients with progression to oral squamous cell carcinoma

2013 ◽  
Vol 169 (1) ◽  
pp. 106-114 ◽  
Author(s):  
S. Segura ◽  
E. Rozas-Muñoz ◽  
A. Toll ◽  
G. Martín-Ezquerra ◽  
E. Masferrer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Oral Lichen Planus ◽  
Oral Lichen

Metastases in Small Thickness Oral Squamous-Cell Carcinoma Arising in Oral Lichen Planus

2001 ◽  
Vol 18 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Michele D. Mignogna ◽  
Lorenzo Lo Muzio ◽  
Lucio Lo Russo ◽  
Stefano Fedele ◽  
Elvira Ruoppo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Oral Lichen Planus ◽  
Small Thickness ◽  
Oral Lichen

scholarly journals LCK, survivin and PI-3K in the molecular biomarker profiling of oral lichen planus and oral squamous cell carcinoma

2009 ◽  
Vol 4 (6) ◽  
pp. 248-257 ◽  
Author(s):  
Oluwadayo Oluwadara ◽  
Luca Giacomelli ◽  
Russell Christensen ◽  
George Kossan ◽  
Raisa Avezova ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Oral Lichen Planus ◽  
Molecular Biomarker ◽  
Oral Lichen

scholarly journals Assessment of salivary thioredoxin levels in oral lichen planus and oral squamous cell carcinoma

2020 ◽  
Author(s):  
Maryam Amirchaghmaghi ◽  
Roya Mahoozi ◽  
Zohreh Dalirsani ◽  
Leila Vazifeh Mostaan ◽  
Seyed Isaac Hashemy ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals Serum and salivary levels of lactate dehydrogenase in oral squamous cell carcinoma, oral lichen planus and oral lichenoid reaction

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Narges Gholizadeh ◽  
Maryam Alipanahi Ramandi ◽  
Maziar Motiee-Langroudi ◽  
Mehrdad Jafari ◽  
Hadi Sharouny ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lactate Dehydrogenase ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Oral Lichen Planus ◽  
Roc Analysis ◽  
Prospective Longitudinal ◽  
Oral Lichen

Abstract Background Increased levels of lactate dehydrogenase (LDH) as a tumor marker have been reported in malignant and some premalignant oral lesions such as oral lichen planus (OLP) and oral lichenoid reactions (OLRs). This study aimed to assess the level of total LDH in the saliva and serum of patients with oral squamous cell carcinoma (OSCC), OLP and OLRs. Methods In this case–control study, the participants were divided into four groups (n = 25) of healthy controls, OLP, OLRs, and OSCC. The serum and stimulated/unstimulated salivary levels of LDH were spectrophotometrically measured using standard LDH kits (Pars Azmoun). One-way ANOVA, Chi-square test, Pearson’s correlation test, and receiver operating characteristic (ROC) analysis were applied to analyze the data. Results The serum and salivary levels of LDH in OSCC patients were significantly higher than that the corresponding values in other groups (P = 0.0001). The serum level of LDH in OLR group was significantly higher than that in the control and OLP groups (P = 0.0001), but the difference in salivary level of LDH was not significant. The ROC analysis showed that both the serum and salivary levels of LDH had significant diagnostic ability for detection of OSCC and OLRs. Significant associations were noted between the serum and salivary levels of LDH. Conclusions Patients with OSCC and OLRs had higher serum levels of LDH than OLP and control groups. Further prospective longitudinal studies are required to assess the tissue level of LDH and monitor the transformation of OLRs because they have low rate of malignant transformation compared with other oral premalignant lesions.

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