scholarly journals Lung function improvement and airways inflammation reduction in asthmatic children after a rehabilitation program at moderate altitude

2017 ◽  
Vol 28 (8) ◽  
pp. 768-775 ◽  
Author(s):  
Eugen Bersuch ◽  
Florian Gräf ◽  
Ellen D. Renner ◽  
Andreas Jung ◽  
Claudia Traidl-Hoffmann ◽  
...  
Keyword(s):  
Lung Function ◽  
Rehabilitation Program ◽  
Moderate Altitude ◽  
Asthmatic Children ◽  
Airways Inflammation

Association between candidate genes and lung function growth in Chinese asthmatic children

2007 ◽  
Vol 0 (0) ◽  
pp. 070806205546004-??? ◽  
Author(s):  
T. F. Leung ◽  
I. H. S. Chan ◽  
G. W. K. Wong ◽  
C. Y. Li ◽  
N. L. S. Tang ◽  
...  
Keyword(s):  
Lung Function ◽  
Candidate Genes ◽  
Asthmatic Children

scholarly journals Airborne Benzo[a]Pyrene may contribute to divergent Pheno-Endotypes in children

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Hyunok Choi ◽  
Miroslav Dostal ◽  
Anna Pastorkova ◽  
Pavel Rossner ◽  
Radim J. Sram
Keyword(s):  
Lung Function ◽  
Atopic Asthma ◽  
T Helper ◽  
T Helper 2 ◽  
Asthmatic Children ◽  
Asthma Outcome ◽  
Unit Increase ◽  
Pyrene Concentration ◽  
Lean Children ◽  
Stratified Analysis

Abstract Background Asthma represents a syndrome for which our understanding of the molecular processes underlying discrete sub-diseases (i.e., endotypes), beyond atopic asthma, is limited. The public health needs to characterize etiology-associated endotype risks is becoming urgent. In particular, the roles of polyaromatic hydrocarbon (PAH), globally distributed combustion by-products, toward the two known endotypes – T helper 2 cell high (Th2) or T helper 2 cell low (non-Th2) – warrants clarification. Objectives To explain ambient B[a]P association with non-atopic asthma (i.e., a proxy of non-Th2 endotype) is markedly different from that with atopic asthma (i.e., a proxy for Th2-high endotype). Methods In a case-control study, we compare the non-atopic as well as atopic asthmatic boys and girls against their respective controls in terms of the ambient Benzo[a]pyrene concentration nearest to their home, plasma 15-Ft2-isoprostane (15-Ft2-isoP), urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), and lung function deficit. We repeated the analysis for i) dichotomous asthma outcome and ii) multinomial asthma—overweight/obese (OV/OB) combined outcomes. Results The non-atopic asthma cases are associated with a significantly higher median B[a]P (11.16 ng/m3) compared to that in the non-atopic controls (3.83 ng/m3; P-value < 0.001). In asthma-OV/OB stratified analysis, the non-atopic girls with lean and OV/OB asthma are associated with a step-wisely elevated B[a]P (median,11.16 and 18.00 ng/m3, respectively), compared to the non-atopic lean control girls (median, 4.28 ng/m3, P-value < 0.001). In contrast, atopic asthmatic children (2.73 ng/m3) are not associated with a significantly elevated median B[a]P, compared to the atopic control children (2.60 ng/m3; P-value > 0.05). Based on the logistic regression model, on ln-unit increate in B[a]P is associated with 4.7-times greater odds (95% CI, 1.9–11.5, P = 0.001) of asthma among the non-atopic boys. The same unit increase in B[a]P is associated with 44.8-times greater odds (95% CI, 4.7–428.2, P = 0.001) among the non-atopic girls after adjusting for urinary Cotinine, lung function deficit, 15-Ft2-isoP, and 8-oxodG. Conclusions Ambient B[a]P is robustly associated with non-atopic asthma, while it has no clear associations with atopic asthma among lean children. Furthermore, lung function deficit, 15-Ft2-isoP, and 8-oxodG are associated with profound alteration of B[a]P-asthma associations among the non-atopic children.

Remote monitoring of lung function in asthmatic children with telespirometry

2021 ◽  
Author(s):  
József Tolnai ◽  
Ferenc Peták ◽  
Roberta Südy ◽  
Gergely H. Fodor ◽  
Zoltán Novák
Keyword(s):  
Lung Function ◽  
Remote Monitoring ◽  
Asthmatic Children

scholarly journals Effects of the pulmonary rehabilitation program on the quality of life of asthmatic children and their parents

2008 ◽  
Vol 15 (3) ◽  
Author(s):  
Ivana Mara Oliveira Rezende ◽  
Ana Luisa Dália Moura ◽  
Bibiana Carolina Costa ◽  
Juliana Machado de Faria ◽  
Crisciane Almeida ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pulmonary Rehabilitation ◽  
Rehabilitation Program ◽  
Asthmatic Children ◽  
Pulmonary Rehabilitation Program

scholarly journals Respiratory function declines in children with asthma associated with chemical species of fine particulate matter (PM2.5) in Nagasaki, Japan

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yoonhee Kim ◽  
Eun Ha Park ◽  
Chris Fook Sheng Ng ◽  
Yeonseung Chung ◽  
Kunio Hashimoto ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Urban Areas ◽  
Chemical Species ◽  
Mixed Effects ◽  
Linear Mixed Effects Model ◽  
Linear Mixed Effects ◽  
Asthmatic Children ◽  
Transboundary Air Pollution ◽  
Children With Asthma

Abstract Background The differential effects of PM2.5 fractions on children’s lung function remain inconclusive. This study aimed to examine whether lung function in asthmatic children was associated with increased PM2.5 fractions in urban areas in Nagasaki prefecture, Japan, where the air pollution level is relatively low but influenced by transboundary air pollution. Methods We conducted a multiyear panel study of 73 asthmatic children (boys, 60.3%; mean age, 8.2 years) spanning spring 2014–2016 in two cities. We collected self-measured peak expiratory flow (PEF) twice a day and daily time-series data for PM2.5 total mass and its chemical species. We fitted a linear mixed effects model to examine short-term associations between PEF and PM2.5, adjusting for individual and time-varying confounders. A generalized linear mixed effects model was also used to estimate the association for worsening asthma defined by severe PEF decline. Back-trajectory and cluster analyses were used to investigate the long-range transboundary PM2.5 in the study areas. Results We found that morning PEFs were adversely associated with higher levels of sulfate (− 1.61 L/min; 95% CI: − 3.07, − 0.15) in Nagasaki city and organic carbon (OC) (− 1.02 L/min; 95% CI: − 1.94, − 0.09) in Isahaya city, per interquartile range (IQR) increase at lag1. In addition, we observed consistent findings for worsening asthma, with higher odds of severe PEF decline in the morning for sulfate (odds ratio (OR) = 2.31; 95% CI: 1.12, 4.77) and ammonium (OR = 1.73; 95% CI: 1.06, 2.84) in Nagasaki city and OC (OR = 1.51; 95% CI: 1.06, 2.15) in Isahaya city, per IQR increase at lag1. The significant chemical species were higher on days that could be largely attributed to the path of Northeast China origin (for sulfate and ammonium) or both the same path and local sources (for OC) than by other clusters. Conclusions This study provides evidence of the differential effects of PM2.5 fractions on lung function among asthmatic children in urban areas, where the Japanese national standards of air quality have been nearly met. Continuous efforts to promote mitigation actions and public awareness of hazardous transboundary air pollution are needed to protect susceptible children with asthma.

Lung function changes in asthmatic children treated with HFA-BDP

2011 ◽  
Vol 46 (9) ◽  
pp. 837-841 ◽  
Author(s):  
Nemr Eid ◽  
Ronald Morton
Keyword(s):  
Lung Function ◽  
Asthmatic Children

scholarly journals Relationship between Exhaled Nitric Oxide and Small Airway Lung Function in Normal and Asthmatic Children

2011 ◽  
Vol 60 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Naoki Nakajima ◽  
Hiroyuki Mochizuki ◽  
Reiko Muramatsu ◽  
Satomi Hagiwara ◽  
Takahisa Mizuno ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Function ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Asthmatic Children

Insulin resistance and lung function in obese asthmatic pre-pubertal children

2018 ◽  
Vol 31 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Paola Di Filippo ◽  
Alessandra Scaparrotta ◽  
Daniele Rapino ◽  
Tommaso de Giorgis ◽  
Marianna Immacolata Petrosino ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lung Function ◽  
Statistical Significance ◽  
Serum Levels ◽  
Forced Expiratory Volume ◽  
Normal Weight ◽  
Model Assessment ◽  
Obese Children ◽  
Asthmatic Children ◽  
Insulin Resistant

AbstractBackground:Recent findings have supposed that the underlying association between the increased prevalence of both asthma and obesity may be insulin resistance (IR).Methods:Insulin and glucose serum levels were analyzed to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) for IR in 98 pre-pubertal children. Lung function and allergy status evaluation were performed. The study population was divided into four groups: (1) obese asthmatic children (ObA); (2) normal-weight asthmatic children (NwA); (3) normal-weight non-asthmatic children (Nw) and (4) obese non-asthmatic children (Ob).Results:Forced expiratory volume in 1 s (FEV1) was slightly lower in obese subjects compared with normal-weight subjects and forced vital capacity (FVC) appeared lower in asthmatics, whereas between non-asthmatics subjects, it was lower in the obese group than in the normal-weight one. The post hoc analysis revealed a statistically significant reduction in FEV1, peak expiratory flow (PEF), forced expiratory flows (FEF) between 50% and 25% of the FVC (FEF50and FEF25) between ObA and Nw and in FEV1, FVC, PEF, FEF50and FEF25between NwA and Nw, but no statistically significant differences of lung function parameters were observed between ObA and NwA. We found an inverse relationship between HOMA-IR and all spirometric parameters, although without any statistical significance. We also observed a significantly lower FVC in insulin-resistant children (HOMA-IR>95th percentile) (p=0.03).Conclusions:This study suggests that lung function could be early altered in obese children, already in pre-pubertal age. Although IR should not manifest its effects on lungs in pre-pubertal obese children, the prevention or treatment of obesity in the pre-pubertal period may prevent definitive negative effects on lungs.

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