Pediatric leukemia cutis: A case series

2019 ◽  
Vol 36 (5) ◽  
pp. 658-663 ◽  
Author(s):  
Elena Corina Andriescu ◽  
Carrie C. Coughlin ◽  
Carol E. Cheng ◽  
Vimal H. Prajapati ◽  
Jennifer T. Huang ◽  
...  
Keyword(s):  
Case Series ◽  
Pediatric Leukemia ◽  
Leukemia Cutis

scholarly journals Intrathecal Methotrexate Containing the Preservative Benzyl Alcohol Erroneously Administered in Pediatric Leukemia Patients: Clinical Course and Preventive Process

2020 ◽  
Vol 25 (4) ◽  
pp. 328-331 ◽  
Author(s):  
Yoav H. Messinger ◽  
Kim L. Maxa ◽  
Emma M. Hennen ◽  
Nathan P. Gossai ◽  
David S. Hoff
Keyword(s):  
Benzyl Alcohol ◽  
Lymphoblastic Leukemia ◽  
Case Series ◽  
Intrathecal Chemotherapy ◽  
Intrathecal Methotrexate ◽  
Drug Shortage ◽  
Common Procedure ◽  
Pediatric Leukemia ◽  
Parenteral Dose ◽  
Direct Delivery

Administration of intrathecal chemotherapy for leukemia is a common procedure in pediatric oncology. The direct delivery of drug into the cerebral spinal fluid requires that no preservative be used. Preserved drugs administered in error can result in significant neurotoxicity. A case series is described where preservative-containing methotrexate was incidentally administered intrathecally. All patients were treated at Children's Hospitals and Clinics of Minnesota. Medical records of the patients affected were reviewed and abstracted for this report. Four children with acute lymphoblastic leukemia received 1 dose of intrathecal methotrexate that contained 0.07% benzyl alcohol in January 2019. Overall, minimal to no symptoms were seen after dosing. The error was traced to a drug shortage in which benzyl alcohol–containing methotrexate was obtained and incorrectly stocked. A novel replacement drug procurement process was developed within our institution. The process includes sequestered queues where a drug awaits evaluation and independent double check of entry accuracy in the electronic health record and pharmacy parenteral dose preparation software prior to release and use. In contrast to IV administration, intrathecal benzyl alcohol at concentrations ≥ 0.9% can cause significant neurotoxicity. Although minimal, if any, neurotoxicity was seen in patients who received a 10-fold lower concentration of benzyl alcohol than previously associated with complications, all institutions should recognize the potential for this error and implement similar safety precautions to ensure that this type of error will not occur.

scholarly journals Dermoscopic features of leukemia cutis—Case series

2021 ◽  
Vol 66 (2) ◽  
pp. 187
Author(s):  
M Slawinska ◽  
M Sokołowska-Wojdyło ◽  
W Biernat ◽  
A Zaryczañska ◽  
RJ Nowicki ◽  
...  
Keyword(s):  
Case Series ◽  
Leukemia Cutis

scholarly journals Pediatric Leukemia Cutis: Darier’s Sign

2021 ◽  
Vol 6 (1) ◽  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Mast Cells ◽  
Lymphoblastic Leukemia ◽  
Lymphoid Cells ◽  
Neoplastic Cells ◽  
Pediatric Leukemia ◽  
Myeloid Lineage ◽  
Histopathological Findings ◽  
Leukemia Cutis

Leukemia Cutis (LC) is defined as infiltration and proliferation of neoplastic cells of lymphoid or myeloid lineage in the epidermis, dermis or hipodermis. The case of a 7-month-old infant with Leukemia Cutis, characterized by papules, nodules with a positive Darier’s sign, with histopathological findings of an infiltrate of monomorphic lymphoid cells in the dermis and hypodermis, without the presence of mast cells, as a manifestation before acute lymphoblastic leukemia is presented in this article.

scholarly journals FLT3mutation incidence and timing of origin in a population case series of pediatric leukemia

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Patrick Chang ◽  
Michelle Kang ◽  
Anny Xiao ◽  
Jeffrey Chang ◽  
James Feusner ◽  
...  
Keyword(s):  
Case Series ◽  
Pediatric Leukemia

Abstract #856 A Case Series Review of Clinical and Biochemical Characteristics of Pituitary Abcess in Mexican Patients

2018 ◽  
Vol 24 ◽  
pp. 202-203
Author(s):  
Mireya Perez-Guzman ◽  
Alfredo Nava de la Vega ◽  
Arturo Pena Velarde ◽  
Tania Raisha Torres Victoria ◽  
Froylan Martinez-Sanchez ◽  
...  
Keyword(s):  
Case Series ◽  
Biochemical Characteristics ◽  
Mexican Patients

Cannabis-associated arteritis

VASA ◽  
2010 ◽  
Vol 39 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Grotenhermen
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Case Series ◽  
Cardiovascular Effects ◽  
Causative Factor ◽  
Cannabis Use ◽  
Thromboangiitis Obliterans ◽  
Pathological Features ◽  
Scientific Support ◽  
Clinical And Pathological Features

Background: To investigate the hypothesis that cases of arteritis similar to thromboangiitis obliterans (TAO) and associated with the use of cannabis were caused by cannabis or THC (dronabinol), or that cannabis use is a co-factor of TAO. Patients and methods: A systematic review on case reports and the literature on so-called cannabis arteritis, TAO, and cardiovascular effects of cannabinoids was conducted. Results: Fifteen reports with 57 cases of an arteritis associated with the use of cannabis and two additional case series of TAO, in which some patients also used cannabis, were identified. Clinical and pathological features of cannabis-associated arteritis do not differ from TAO and the major risk factor of TAO, tobacco use, was present in most, if not in all of these cases. The proposed pathophysiological mechanisms for the development of an arteritis by cannabis use are not substantiated. Conclusions: The hypothesis of cannabis being a causative factor or co-factor of TAO or an arteritis similar to TAO is not supported by the available evidence. The use of the term “cannabis arteritis” should be avoided until or unless more convincing scientific support is forthcoming.

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