Impacts of donor-specific anti-HLA antibodies and antibody-mediated rejection on outcomes after intestinal transplantation in children

2017 ◽  
Vol 21 (2) ◽  
pp. e12847 ◽  
Author(s):  
L.-M. Petit ◽  
M. Rabant ◽  
D. Canioni ◽  
C. Suberbielle-Boissel ◽  
O. Goulet ◽  
...  
Keyword(s):  
Intestinal Transplantation ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection

scholarly journals The determinants, biomarkers, and consequences of microvascular injury in kidney transplant recipients

2019 ◽  
Vol 316 (1) ◽  
pp. F9-F19 ◽  
Author(s):  
Alice Doreille ◽  
Mélanie Dieudé ◽  
Heloise Cardinal
Keyword(s):  
Kidney Disease ◽  
Kidney Transplant ◽  
Interstitial Fibrosis ◽  
Ischemia Reperfusion ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Hla Antibodies ◽  
Microvascular Injury ◽  
Antibody Mediated Rejection ◽  
Peritubular Capillaries

Independent of the initial cause of kidney disease, microvascular injury to the peritubular capillary network appears to play a central role in the development of interstitial fibrosis in both native and transplanted kidney disease. This association is explained by mechanisms such as the upregulation of profibrotic genes and epigenetic changes induced by hypoxia, capillary leakage, endothelial and pericyte transition to interstitial fibroblasts, as well as modifications in the secretome of endothelial cells. Alloimmune injury due to antibody-mediated rejection and ischemia-reperfusion injury are the two main etiologies of microvascular damage in kidney transplant recipients. The presence of circulating donor-specific anti-human leukocyte antigen (HLA) antibodies, histological findings, such as diffuse C4d staining in peritubular capillaries, and the extent and severity of peritubular capillaritis, are commonly used clinically to provide both diagnostic and prognostic information. Complement-dependent assays, circulating non-HLA antibodies, or evaluation of the microvasculature with novel imaging techniques are the subject of ongoing studies.

scholarly journals Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient

2021 ◽  
Vol 10 (16) ◽  
pp. 3656
Author(s):  
Danae Olaso ◽  
Miriam Manook ◽  
Dimitrios Moris ◽  
Stuart Knechtle ◽  
Jean Kwun
Keyword(s):  
Immune Response ◽  
Transplant Recipient ◽  
Kidney Transplant Recipient ◽  
Human Leukocyte ◽  
Immunosuppressive Regimen ◽  
Human Leukocyte Antigens ◽  
Donor Pool ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection ◽  
Leukocyte Antigens

Patients with previous sensitization events against anti-human leukocyte antigens (HLA) often have circulating anti-HLA antibodies. Following organ transplantation, sensitized patients have higher rates of antibody-mediated rejection (AMR) compared to those who are non-sensitized. More stringent donor matching is required for these patients, which results in a reduced donor pool and increased time on the waitlist. Current approaches for sensitized patients focus on reducing preformed antibodies that preclude transplantation; however, this type of desensitization does not modulate the primed immune response in sensitized patients. Thus, an optimized maintenance immunosuppressive regimen is necessary for highly sensitized patients, which may be distinct from non-sensitized patients. In this review, we will discuss the currently available therapeutic options for induction, maintenance, and adjuvant immunosuppression for sensitized patients.

OR33 The importance of detection of donor-chimerism and anti-donor or anti-recipeint HLA antibodies after liver-contained intestinal transplantation

2017 ◽  
Vol 78 ◽  
pp. 30
Author(s):  
Aiwen Zhang ◽  
Masato Fujiki ◽  
Ajai Khanna ◽  
Yuchu Sun ◽  
Ray Jurcago ◽  
...  
Keyword(s):  
Intestinal Transplantation ◽  
Hla Antibodies ◽  
Donor Chimerism

Histological picture of antibody‐mediated rejection without donor‐specific anti‐HLA antibodies: Clinical presentation and implications for outcome

2018 ◽  
Vol 19 (3) ◽  
pp. 763-780 ◽  
Author(s):  
Aleksandar Senev ◽  
Maarten Coemans ◽  
Evelyne Lerut ◽  
Vicky Van Sandt ◽  
Liesbeth Daniëls ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection ◽  
Histological Picture

Prognostic Value of the Persistence of C1q-Binding Anti-HLA Antibodies in Acute Antibody-Mediated Rejection in Kidney Transplantation

2018 ◽  
Vol 102 (4) ◽  
pp. 688-698 ◽  
Author(s):  
Elodie Bailly ◽  
Dany Anglicheau ◽  
Gilles Blancho ◽  
Philippe Gatault ◽  
Vincent Vuiblet ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Prognostic Value ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection
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