Clearance of Intra-graft Donor Specific Anti-HLA Antibodies in the Early Stage of Antibody-Mediated Rejection Following Rituximab and Apheresis Therapy in Renal Transplantation

2019 ◽  
Vol 51 (5) ◽  
pp. 1365-1370 ◽  
Author(s):  
Tsukasa Nakamura ◽  
Norio Yoshimura ◽  
Kiyokazu Akioka ◽  
Takayuki Shirouzu ◽  
Shintaro Kawai ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Early Stage ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection ◽  
Graft Donor ◽  
Apheresis Therapy

75-P: Preformed Low Reactive Anti-HLA Antibodies Are Associated With Majority of Early Antibody-Mediated Rejection in Renal Transplantation

2010 ◽  
Vol 71 ◽  
pp. S68
Author(s):  
P. Brailey ◽  
E.S. Woodle ◽  
R.R. Alloway ◽  
A.D. Tevar ◽  
M. Cardi ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection

Antibody response to HBV vaccination on dialysis does not correlate with the development of deNovo anti-HLA antibodies after renal transplantation

2017 ◽  
Vol 42 ◽  
pp. 5-8 ◽  
Author(s):  
Teresa Kauke ◽  
Maximilian Link ◽  
Markus Rentsch ◽  
Manfred Stangl ◽  
Markus Guba ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Antibody Response ◽  
Hla Antibodies ◽  
Hbv Vaccination

Outcomes of Combination Therapy for Chronic Antibody-Mediated Rejection in Renal Transplantation

2012 ◽  
Vol 94 (10S) ◽  
pp. 1049
Author(s):  
M.-G. Kim ◽  
H. Y. Kwon ◽  
T. Y. Koo ◽  
Y. J. Kim ◽  
J. H. Park ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Combination Therapy ◽  
Antibody Mediated Rejection

scholarly journals The determinants, biomarkers, and consequences of microvascular injury in kidney transplant recipients

2019 ◽  
Vol 316 (1) ◽  
pp. F9-F19 ◽  
Author(s):  
Alice Doreille ◽  
Mélanie Dieudé ◽  
Heloise Cardinal
Keyword(s):  
Kidney Disease ◽  
Kidney Transplant ◽  
Interstitial Fibrosis ◽  
Ischemia Reperfusion ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Hla Antibodies ◽  
Microvascular Injury ◽  
Antibody Mediated Rejection ◽  
Peritubular Capillaries

Independent of the initial cause of kidney disease, microvascular injury to the peritubular capillary network appears to play a central role in the development of interstitial fibrosis in both native and transplanted kidney disease. This association is explained by mechanisms such as the upregulation of profibrotic genes and epigenetic changes induced by hypoxia, capillary leakage, endothelial and pericyte transition to interstitial fibroblasts, as well as modifications in the secretome of endothelial cells. Alloimmune injury due to antibody-mediated rejection and ischemia-reperfusion injury are the two main etiologies of microvascular damage in kidney transplant recipients. The presence of circulating donor-specific anti-human leukocyte antigen (HLA) antibodies, histological findings, such as diffuse C4d staining in peritubular capillaries, and the extent and severity of peritubular capillaritis, are commonly used clinically to provide both diagnostic and prognostic information. Complement-dependent assays, circulating non-HLA antibodies, or evaluation of the microvasculature with novel imaging techniques are the subject of ongoing studies.

scholarly journals Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient

2021 ◽  
Vol 10 (16) ◽  
pp. 3656
Author(s):  
Danae Olaso ◽  
Miriam Manook ◽  
Dimitrios Moris ◽  
Stuart Knechtle ◽  
Jean Kwun
Keyword(s):  
Immune Response ◽  
Transplant Recipient ◽  
Kidney Transplant Recipient ◽  
Human Leukocyte ◽  
Immunosuppressive Regimen ◽  
Human Leukocyte Antigens ◽  
Donor Pool ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection ◽  
Leukocyte Antigens

Patients with previous sensitization events against anti-human leukocyte antigens (HLA) often have circulating anti-HLA antibodies. Following organ transplantation, sensitized patients have higher rates of antibody-mediated rejection (AMR) compared to those who are non-sensitized. More stringent donor matching is required for these patients, which results in a reduced donor pool and increased time on the waitlist. Current approaches for sensitized patients focus on reducing preformed antibodies that preclude transplantation; however, this type of desensitization does not modulate the primed immune response in sensitized patients. Thus, an optimized maintenance immunosuppressive regimen is necessary for highly sensitized patients, which may be distinct from non-sensitized patients. In this review, we will discuss the currently available therapeutic options for induction, maintenance, and adjuvant immunosuppression for sensitized patients.

ABDR and amino acid triplet HLA mismatches are associated with the development of anti-HLA antibodies after renal transplantation

2004 ◽  
Vol 65 (9-10) ◽  
pp. S46
Author(s):  
Alin Girnita ◽  
Rene Duquesnoy ◽  
Ron Shapiro ◽  
Parmjeet Randhawa ◽  
Joan Martell ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Amino Acid ◽  
Hla Antibodies ◽  
Hla Mismatches ◽  
Amino Acid Triplet

Histological picture of antibody‐mediated rejection without donor‐specific anti‐HLA antibodies: Clinical presentation and implications for outcome

2018 ◽  
Vol 19 (3) ◽  
pp. 763-780 ◽  
Author(s):  
Aleksandar Senev ◽  
Maarten Coemans ◽  
Evelyne Lerut ◽  
Vicky Van Sandt ◽  
Liesbeth Daniëls ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection ◽  
Histological Picture
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