Telomerase reverse transcriptase ( TERT ) promoter mutation correlated with intratumoral heterogeneity in hepatocellular carcinoma

2020 ◽  
Author(s):  
Wit Thun Kwa ◽  
Kathryn Effendi ◽  
Ken Yamazaki ◽  
Naoto Kubota ◽  
Mami Hatano ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Reverse Transcriptase ◽  
Intratumoral Heterogeneity ◽  
Telomerase Reverse Transcriptase ◽  
Tert Promoter Mutation ◽  
Promoter Mutation ◽  
Tert Promoter

Human Telomerase Reverse Transcriptase Gene Promoter Mutation in Serum of Patients with Hepatocellular Carcinoma

Oncology ◽  
2020 ◽  
Vol 98 (5) ◽  
pp. 311-317
Author(s):  
Soichiro Ako ◽  
Kazuhiro Nouso ◽  
Hideaki Kinugasa ◽  
Hiroshi Matsushita ◽  
Hiroyuki Terasawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Reverse Transcriptase ◽  
Gene Promoter ◽  
Telomerase Reverse Transcriptase ◽  
Reverse Transcriptase Gene ◽  
Promoter Mutation ◽  
Human Telomerase Reverse Transcriptase ◽  
Human Telomerase

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

Hepatology ◽  
2014 ◽  
Vol 60 (6) ◽  
pp. 1983-1992 ◽  
Author(s):  
Jean Charles Nault ◽  
Julien Calderaro ◽  
Luca Di Tommaso ◽  
Charles Balabaud ◽  
Elie Serge Zafrani ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Reverse Transcriptase ◽  
Genetic Alteration ◽  
Telomerase Reverse Transcriptase ◽  
Promoter Mutation

Detection of TERT promoter mutation in serum cell‐free DNA using wild‐type blocking PCR combined with Sanger sequencing in hepatocellular carcinoma

2020 ◽  
Vol 92 (12) ◽  
pp. 3604-3608 ◽  
Author(s):  
Norio Akuta ◽  
Fumitaka Suzuki ◽  
Mariko Kobayashi ◽  
Shunichiro Fujiyama ◽  
Yusuke Kawamura ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Sanger Sequencing ◽  
Tert Promoter Mutation ◽  
Wild Type ◽  
Promoter Mutation ◽  
Cell Free Dna ◽  
Free Dna ◽  
Tert Promoter

scholarly journals TERT Promoter Mutation is a Diagnostic and Differential Diagnostic Marker for Tumors with Urothelial Origin

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Shaobo Zhang
Keyword(s):  
Differential Diagnosis ◽  
Diagnostic Marker ◽  
Clinical Implications ◽  
Telomerase Reverse Transcriptase ◽  
Tert Promoter Mutation ◽  
Promoter Mutation ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

Telomerase reverse transcriptase (TERT) promoter mutations have been found in approximately 60–80% of bladder urothelial cancers and its variants of all grades anywhere in the urinary tract. The TERT promoter mutations occur early in urothelial neoplasia and are biomarkers for neoplasm development, recurrence, diagnosis, differential diagnosis, and potentially a therapeutic target. This review highlighted the role of TERT promoter mutations in urothelial tumorigenesis, and the potential clinical implications.

scholarly journals The TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (14) ◽  
pp. 23120-23129 ◽  
Author(s):  
Xiaotian Yuan ◽  
Guanghui Cheng ◽  
Jingya Yu ◽  
Shunzhen Zheng ◽  
Chao Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tert Promoter Mutation ◽  
Promoter Mutation ◽  
Tert Promoter

scholarly journals Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma

Medicine ◽  
2017 ◽  
Vol 96 (5) ◽  
pp. e5766 ◽  
Author(s):  
Hye Won Lee ◽  
Tae In Park ◽  
Se Young Jang ◽  
Soo Young Park ◽  
Won-Jin Park ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Telomere Length ◽  
Clinicopathological Characteristics ◽  
Tert Promoter Mutation ◽  
Promoter Mutation ◽  
Tert Promoter
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