Prostatic fluid composition and semen quality in dogs with benign prostatic hyperplasia undergoing treatment with osaterone acetate

2021 ◽  
Author(s):  
Lluis Ferré‐Dolcet ◽  
Lisa Frigotto ◽  
Barbara Contiero ◽  
Silvia Bedin ◽  
Stefano Romagnoli
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Semen Quality ◽  
Prostatic Hyperplasia ◽  
Fluid Composition ◽  
Prostatic Fluid

scholarly journals Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Daniel S. R. Angrimani ◽  
Maíra M. Brito ◽  
Bruno R. Rui ◽  
Marcílio Nichi ◽  
Camila I. Vannucchi
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Semen Quality ◽  
Clinical Signs ◽  
Negative Influence ◽  
Prostatic Hyperplasia ◽  
Reproductive Disorders ◽  
Short Term ◽  
Prostatic Fluid ◽  
Therapeutic Measures ◽  
Breeding Soundness

Abstract Benign prostatic hyperplasia (BPH) is one of the most important reproductive disorders in aging dogs. Therapeutic measures include orchiectomy and pharmacological treatment, leading to reduction of prostate volume and clinical signs. One of the most common drugs used in BPH treatment is finasteride, but data regarding its possible side effects are scarce. Thus, the aim of this study was to evaluate the effects of BPH and short-term (2 months) finasteride therapy on clinical, endocrinological, and reproductive parameters in dogs. Dogs were allocated into four experimental groups: Non-affected (n = 5), BPH (n = 5), Non-Affected-Finasteride (n = 5) and BPH-Finasteride (n = 5) groups. Dogs were evaluated monthly during 2 months by a complete breeding soundness examination, B-mode ultrasound and Doppler ultrasonography of the testicular artery, hormonal profile (testosterone, estrogen and dihydrotestosterone) and oxidative profile of the prostatic fluid. After 2 months, dogs were gonadectomized and testicles were subjected to histologic analysis. Finasteride treatment reduced dihydrotestosterone concentrations, without negative influence on semen quality and also reverted testicular hemodynamics changes of BPH. On the other hand, BPH was accompanied by significant changes in testosterone and estrogen concentrations and semen quality, mainly related to sperm kinetics alterations. In conclusion, BPH dogs have important hormonal and sperm alterations, however, short-term finasteride treatment (2 months) was able to reduce overall effects of BPH, thus representing a method of therapy for BPH treatment.

Systematic characterization of human prostatic fluid proteins with two-dimensional electrophoresis.

1984 ◽  
Vol 30 (12) ◽  
pp. 2026-2030 ◽  
Author(s):  
Y C Tsai ◽  
H H Harrison ◽  
C Lee ◽  
J A Daufeldt ◽  
L Oliver ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Serum Proteins ◽  
Prostatic Hyperplasia ◽  
Affinity Column ◽  
Two Dimensional ◽  
Differential Analysis ◽  
Protein Patterns ◽  
Prostatic Fluid ◽  
Serum Components

Abstract We present a systematic analysis of human prostatic fluid with two-dimensional gel electrophoresis (the ISO-DALT system) and a characterization of normal and disease-related protein patterns. A reference map for prostatic fluid proteins was established by analysis of pooled prostatic fluids from 80 men (age less than or equal to 50 years) without prostatic lesions. Proteins in prostatic fluid that share immunogenicity with serum proteins were identified by use of antibody to whole human-serum protein in an affinity-column fractionation of a reference pool and differential analysis of the absorbed (serum components) and unabsorbed (non-serum components) fractions. Individual prostatic fluids from 30 patients (eight with prostatic cancer, 10 with prostatitis and benign prostatic hyperplasia, six with benign prostatic hyperplasia alone, and six with asymptomatic chronic prostatitis) were scored qualitatively with respect to the presence or absence of 57 major prostatic fluid proteins. Statistically significant, disease-correlated alterations were observed for at least eight of the proteins so scored.

1505: Evaluation of Bother Score for Each Symptom is Necessary for Managemnt of QOL in Patients with Lower Urinary TRCT Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia (BPH)

2007 ◽  
Vol 177 (4S) ◽  
pp. 496-497
Author(s):  
Masaki Yoshida ◽  
Akita Inadome ◽  
Koichi Masunaga ◽  
Yoshihiro Maeda ◽  
You Satoji ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Lower Urinary

1438: Benign Prostatic Hyperplasia Outcomes 12 Months after Initiating Medical Management: An Analysis of Managed Care Data

2006 ◽  
Vol 175 (4S) ◽  
pp. 464-465
Author(s):  
Michael J. Naslund ◽  
Muta M. Issa ◽  
Libby Black ◽  
Michael Eaddy ◽  
Manan Shah
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Managed Care ◽  
Medical Management ◽  
Prostatic Hyperplasia
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