scholarly journals Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Daniel S. R. Angrimani ◽  
Maíra M. Brito ◽  
Bruno R. Rui ◽  
Marcílio Nichi ◽  
Camila I. Vannucchi
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Semen Quality ◽  
Clinical Signs ◽  
Negative Influence ◽  
Prostatic Hyperplasia ◽  
Reproductive Disorders ◽  
Short Term ◽  
Prostatic Fluid ◽  
Therapeutic Measures ◽  
Breeding Soundness

Abstract Benign prostatic hyperplasia (BPH) is one of the most important reproductive disorders in aging dogs. Therapeutic measures include orchiectomy and pharmacological treatment, leading to reduction of prostate volume and clinical signs. One of the most common drugs used in BPH treatment is finasteride, but data regarding its possible side effects are scarce. Thus, the aim of this study was to evaluate the effects of BPH and short-term (2 months) finasteride therapy on clinical, endocrinological, and reproductive parameters in dogs. Dogs were allocated into four experimental groups: Non-affected (n = 5), BPH (n = 5), Non-Affected-Finasteride (n = 5) and BPH-Finasteride (n = 5) groups. Dogs were evaluated monthly during 2 months by a complete breeding soundness examination, B-mode ultrasound and Doppler ultrasonography of the testicular artery, hormonal profile (testosterone, estrogen and dihydrotestosterone) and oxidative profile of the prostatic fluid. After 2 months, dogs were gonadectomized and testicles were subjected to histologic analysis. Finasteride treatment reduced dihydrotestosterone concentrations, without negative influence on semen quality and also reverted testicular hemodynamics changes of BPH. On the other hand, BPH was accompanied by significant changes in testosterone and estrogen concentrations and semen quality, mainly related to sperm kinetics alterations. In conclusion, BPH dogs have important hormonal and sperm alterations, however, short-term finasteride treatment (2 months) was able to reduce overall effects of BPH, thus representing a method of therapy for BPH treatment.

scholarly journals Gambaran disfungsi ereksi pada pasien dengan benign prostatic hyperplasia (BPH) di Klinik Advent Tikala Manado

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Michael B. Tawale ◽  
Lydia Tendean ◽  
Lusiana Setiawati
Keyword(s):  
Erectile Dysfunction ◽  
Benign Prostatic Hyperplasia ◽  
Clinical Signs ◽  
Sampling Technique ◽  
Descriptive Study ◽  
Prostatic Hyperplasia ◽  
Cross Sectional ◽  
Purposive Sampling ◽  
Post Surgery ◽  
Cross Sectional Design

Abstract: Erectile dysfunction (ED) is an inability to achieve an erection sufficient for intercourse with his partner which causes dissatisfaction for both of them. The etiology of ED is classified as psychogenic, organic, drug abuse, and also by post-surgery. Benign prostatic hyperplasia (BPH) is a disease caused by aging. BPH clinical signs usually appear in more than 50% of men aged ≥50 years. This was a survey-descriptive study with a cross sectional design. Samples were obtained by using purposive sampling technique. Respondents were patients at Efrata Adventist Clinic in Manado. The instrument in this study was modified IIEF-5 questionnaire. The results showed that based on the duration of BPH, respondents who suffered from BPH >3 years were as many as 75.0% and <1 year were 7.1%. Based on the ages, respondents of 61-70 years were 46.5 and of 41-50 years were 7.1%. The erectile dysfunction of respondents was classified as moderate 42.9%, mild-moderate 32.1%, severe 17.9%, and mild 7.1%. Conclusion: Most of the erectile dysfunction with BPH >3 years was classified as moderate.Keywords: erectile dysfunction, BPH Abstrak: Disfungsi ereksi (DE) yaitu suatu ketidakmampuan untuk mencapai ereksi yang cukup untuk melakukan senggama bersama pasangannya sehingga menimbulkan ketidakpuasan diantara keduanya. Etiologi DE diklasifikasikan menjadi psikogenik, organik, penyalahgunaan obat-obatan dan juga oleh pasca tindakan bedah. Benign prostatic hyperplasia (BPH) adalah penyakit yang disebabkan oleh penuaan. Tanda klinis BPH biasanya muncul pada lebih dari 50% laki-laki yang berusia 50 tahun ke atas. Jenis penelitian ialah survei deskriptif-observasional dengan desain potong lintang. Pengambilan sampel dilakukan dengan teknik purposive sampling pada seluruh pasien di Klinik Advent Efrata Tikala Manado. Variabel penelitian ialah pasien BPH di Klinik Advent Tikala Manado. Instrumen penelitian menggunakan kuesioner IIEF-5 yang telah dimodifikasi. Hasil penelitian mendapatkan berdasarkan lama menderita BPH, responden yang menderita BPH >3 tahun sebesar 75,0%; 1-2 tahun sebesar 17,9%; dan <1 tahun sebesar 7,1%. Berdasarkan usia responden berusia 61-70 tahun sebesar 46,5% dan 41-50 tahun sebesar 7,1%. DE pada BPH paling banyak termasuk klasifikasi sedang (42,9%), diikuti ringan-sedang (32,1%), berat (17,9%) dan ringan (7,1%). Simpulan: Sebagian besar pasien DE dengan BPH >3 tahun termasuk dalam klasifikasi sedang. Kata kunci: disfungsi ereksi, BPH

Systematic characterization of human prostatic fluid proteins with two-dimensional electrophoresis.

1984 ◽  
Vol 30 (12) ◽  
pp. 2026-2030 ◽  
Author(s):  
Y C Tsai ◽  
H H Harrison ◽  
C Lee ◽  
J A Daufeldt ◽  
L Oliver ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Serum Proteins ◽  
Prostatic Hyperplasia ◽  
Affinity Column ◽  
Two Dimensional ◽  
Differential Analysis ◽  
Protein Patterns ◽  
Prostatic Fluid ◽  
Serum Components

Abstract We present a systematic analysis of human prostatic fluid with two-dimensional gel electrophoresis (the ISO-DALT system) and a characterization of normal and disease-related protein patterns. A reference map for prostatic fluid proteins was established by analysis of pooled prostatic fluids from 80 men (age less than or equal to 50 years) without prostatic lesions. Proteins in prostatic fluid that share immunogenicity with serum proteins were identified by use of antibody to whole human-serum protein in an affinity-column fractionation of a reference pool and differential analysis of the absorbed (serum components) and unabsorbed (non-serum components) fractions. Individual prostatic fluids from 30 patients (eight with prostatic cancer, 10 with prostatitis and benign prostatic hyperplasia, six with benign prostatic hyperplasia alone, and six with asymptomatic chronic prostatitis) were scored qualitatively with respect to the presence or absence of 57 major prostatic fluid proteins. Statistically significant, disease-correlated alterations were observed for at least eight of the proteins so scored.

scholarly journals Rezum: a new transurethral water vapour therapy for benign prostatic hyperplasia

2018 ◽  
Vol 10 (11) ◽  
pp. 327-333 ◽  
Author(s):  
Jennifer Westwood ◽  
Robert Geraghty ◽  
Patrick Jones ◽  
Bhavan P. Rai ◽  
Bhaskar K. Somani
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Minimally Invasive ◽  
Sexual Function ◽  
Water Vapour ◽  
Thermal Energy ◽  
Prostatic Hyperplasia ◽  
Benign Prostatic Enlargement ◽  
Short Term ◽  
Safety And Efficacy ◽  
Prostatic Enlargement

Rezum is a minimally invasive transurethral water vapour therapy for benign prostatic enlargement which uses thermal energy for treatment. The short-term results show it to have good outcomes with a potential for outpatient-based treatment preserving sexual function. This review serves to provide an overview of the technique and evaluate its safety and efficacy.

Possible drug-induced follicular mucinosis in a dog

2019 ◽  
Vol 7 (2) ◽  
pp. e000811
Author(s):  
Tatiana de Brito Lima ◽  
Laura Ordeix ◽  
Dolors Fondevila
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Complete Remission ◽  
Clinical Signs ◽  
Prostatic Hyperplasia ◽  
Daily Regimen ◽  
Drug Induced ◽  
History Of ◽  
Anti Inflammatory ◽  
One Year ◽  
Entire Male

A nine-year-old, entire male basset hound presented with one-year history of pruritus and patchy to diffuse alopecia accompanied by erythema, starting a few days after applying an implant of deslorelin for treatment of benign prostatic hyperplasia. Dermatopathological examination was diagnostic for follicular mucinosis, accompanied by a characteristic lymphocytic mural folliculitis at the level of the isthmus. Partial improvement with anti-inflammatory doses of prednisone was observed. Thereafter, oral ciclosporin was administered on a daily regimen until complete remission was achieved, after which it was gradually tapered until withdrawal. No other implants were applied thereafter, and two years later the patient remains free of clinical signs.

Effect of Short-term Dutasteride Therapy on Prostate Vascularity in Patients With Benign Prostatic Hyperplasia: A Pilot Study

Urology ◽  
2009 ◽  
Vol 73 (6) ◽  
pp. 1274-1278 ◽  
Author(s):  
Sergey Kravchick ◽  
Shmuel Cytron ◽  
Alla Mamonov ◽  
Ronit Peled ◽  
Lina Linov
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Pilot Study ◽  
Prostatic Hyperplasia ◽  
Short Term
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