RESTORATION OF CORTICOSTEROID SENSITIVITY IN CIGARETTE SMOKE-INDUCED LUNG INJURY MODEL BY ANDROGRAPHOLIDE

Respirology ◽  
2017 ◽  
Vol 22 ◽  
pp. 6-7
Keyword(s):  
Lung Injury ◽  
Cigarette Smoke ◽  
Injury Model ◽  
Lung Injury Model

scholarly journals Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
John N. Cronin ◽  
João Batista Borges ◽  
Douglas C. Crockett ◽  
Andrew D. Farmery ◽  
Göran Hedenstierna ◽  
...  
Keyword(s):  
Lung Injury ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Lung Density ◽  
Density Distributions ◽  
Single Slice ◽  
Injury Model ◽  
Lung Injury Model ◽  
Ct Density ◽  
Surfactant Depletion

Abstract Background Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal, physiological variation in aeration and lung density in experimental lung injury. The ability of dCT to predict whole-lung values is unclear, especially for dual-energy CT (DECT) variables. Additionally, the effect of inspiration-related lung movement on CT variables has not yet been quantified. Methods Eight domestic pigs were studied under general anaesthesia, including four following saline-lavage surfactant depletion (lung injury model). DECT, dCT and whole-lung images were collected at 12 ventilatory settings. Whole-lung single energy scans images were collected during expiratory and inspiratory apnoeas at positive end-expiratory pressures from 0 to 20 cmH2O. Means and distributions of CT variables were calculated for both dCT and whole-lung images. The cranio-caudal displacement of the anatomical slice was measured from whole-lung images. Results Mean CT density and volume fractions of soft tissue, gas, iodinated blood, atelectasis, poor aeration, normal aeration and overdistension correlated between dCT and the whole lung (r2 0.75–0.94) with agreement between CT density distributions (r 0.89–0.97). Inspiration increased the matching between dCT and whole-lung values and was associated with a movement of 32% (SD 15%) of the imaged slice out of the scanner field-of-view. This effect introduced an artefactual increase in dCT mean CT density during inspiration, opposite to that caused by the underlying physiology. Conclusions Overall, dCT closely approximates whole-lung aeration and density. This approximation is improved by inspiration where a decrease in CT density and atelectasis can be interpreted as physiological rather than artefactual.

PULMONARY FIBROBLAST FUNCTION IN AN ACUTE LUNG INJURY MODEL

1994 ◽  
Vol 37 (1) ◽  
pp. 156
Author(s):  
Andrew Mikulaschek ◽  
Stantey Z Trooskin ◽  
Allen Nonn ◽  
Jason Winfield
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Injury Model ◽  
Lung Injury Model ◽  
Pulmonary Fibroblast

Derivation of recruitment function from the pressure–volume curve in an acute lung injury model

2015 ◽  
Vol 205 ◽  
pp. 16-20 ◽  
Author(s):  
Yoshihiro Uzawa ◽  
Mikiya Otsuji ◽  
Koichi Nakazawa ◽  
Wei Fan ◽  
Yoshitsugu Yamada
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Volume Curve ◽  
Pressure Volume Curve ◽  
Injury Model ◽  
Lung Injury Model

scholarly journals Intratracheal Pulmonary Ventilation vs. Conventional Ventilation in an Oleic Acid Lung Injury Model in the Young Lamb 197

1998 ◽  
Vol 43 ◽  
pp. 36-36
Author(s):  
Allyson M Goodman ◽  
L Kyle Walker ◽  
Oswaldo Rivera ◽  
Winslow R Seale ◽  
Billie L Short
Keyword(s):  
Oleic Acid ◽  
Lung Injury ◽  
Pulmonary Ventilation ◽  
Conventional Ventilation ◽  
Injury Model ◽  
Lung Injury Model

AIRWAY PRESSURE RELEASE VENTILATION (APRV) IN A PEDIATRIC ACUTE LUNG INJURY MODEL

1990 ◽  
Vol 18 (Supplement) ◽  
pp. S231 ◽  
Author(s):  
Lynn D. Martin ◽  
Anthony L. Bilenki ◽  
James F. Rafferty ◽  
Randall C. Wetzel
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Airway Pressure ◽  
Airway Pressure Release Ventilation ◽  
Pressure Release ◽  
Injury Model ◽  
Lung Injury Model ◽  
Pressure Release Ventilation

scholarly journals CNP-miR146a Reduces Ventilator-Induced Lung Injury in a Lipopolysaccharide Acute Lung Injury Model

2020 ◽  
Author(s):  
A.M. Wallbank ◽  
S. Niemiec ◽  
A. Louiselle ◽  
C. Zgheib ◽  
E. Nozik-Grayck ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Ventilator Induced Lung Injury ◽  
Injury Model ◽  
Lung Injury Model
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