scholarly journals Association of Group‐specific Component Exon 11 Polymorphisms with Bronchial Asthma in Children and Adolescents

2018 ◽  
pp. e12740 ◽  
Author(s):  
Manal S. Fawzy ◽  
Mona G. Elgazzaz ◽  
Ahmed Ibrahim ◽  
Mohammad H. Hussein ◽  
Motaz S. Khashana ◽  
...  
Author(s):  
Magomed I. Izrailov ◽  
A. M. Aliskandiyev ◽  
Ya. M. Yakhiaev

The prevalence of bronchial asthma (BA) in recent years has been steadily increasing in many countries of the world. Among allergic diseases and respiratory diseases, asthma occupies a leading position. In order to study the prevalence of asthma, we performed questionnaire survey of 6326 schoolchildren, including 3125 cases aged of 7-8 years and children of 13-14 years according to the «ISAAC» program. The prevalence of bronchial asthma in children in the mountain climate is about 8.43 per 1,000 children, which is almost two times lower than in the low-lying zone, in urban children the prevalence of bronchial asthma is 25 per 1000 children. Among the risk factors for the formation of bronchial asthma in children the leading place is occupied by hereditary, occupy antenatal and social sanitary risk factors.


2020 ◽  
pp. 101-107
Author(s):  
T. N. Surovenko ◽  
E. F. Glushkova

Up to 22% of the population in the world suffer from bronchial asthma according to the data from different regions and sources. This is about 358 million people. At the same time, accurate figures for the prevalence of this disease cannot be obtained. Despite the many ongoing studies of this disease, developed treatment options, asthma hasn’t become a fully controlled disease. The problem of control and treatment of the disease as well as patient compliance is of great concern to modern clinicians. Every year GINA releases new documents and makes changes in the treatment and diagnosis of this chronic bronchopulmonary disease. Children’s asthma has become not only the most common chronic disease, but also the most common cause of children hospitalization.This article provides an overview of the international randomized clinical trials results and expert opinions regarding the treatment of uncontrolled bronchial asthma in children and adolescents. The results of 2017–2020 meta-analyzes regarding the use of tiotropium in children and adolescents are described. The use of basic therapy schemes is disclosed, including the use of tiotropium bromide in accordance with the recommendations of the Russian Respiratory Society and GINA.The authors also presented a clinical case of difficultly controlled bronchial asthma in a child of 12 years old. The use of tiotropium bromide in this patient is described in detail and the effectiveness of this drug is demonstrated.


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