Surveillance and investigative diagnosis of a poultry flock in Great Britain co‐infected with an influenza A virus and an avirulent avian avulavirus type 1

2019 ◽  
Vol 66 (2) ◽  
pp. 696-704
Author(s):  
Scott M. Reid ◽  
Ruth Manvell ◽  
James M. Seekings ◽  
Vanessa Ceeraz ◽  
Helen Errington ◽  
...  
Keyword(s):  
Great Britain ◽  
Influenza A Virus ◽  
Influenza A ◽  
Poultry Flock

Disease outbreaks in pigs in Great Britain due to an influenza A virus of H1N2 subtype

1995 ◽  
Vol 136 (13) ◽  
pp. 328-329 ◽  
Author(s):  
I. Brown ◽  
P. Chakraverty ◽  
P. Harris ◽  
D. Alexander
Keyword(s):  
Great Britain ◽  
Influenza A Virus ◽  
Influenza A ◽  
Disease Outbreaks

scholarly journals Serological evidence of continuing infection of swine in Great Britain with an influenza A virus (H3N2)

1978 ◽  
Vol 80 (3) ◽  
pp. 415-422 ◽  
Author(s):  
M. S. Chapman ◽  
P. H. Lamont ◽  
J. W. Harkness
Keyword(s):  
Great Britain ◽  
Influenza A Virus ◽  
Small Proportion ◽  
Human Population ◽  
Influenza A ◽  
Haemagglutination Inhibition ◽  
Swine Influenza ◽  
Seasonal Fluctuations ◽  
Serological Evidence ◽  
Serum Samples

SummarySerum samples collected from swine and cattle in Great Britain at various times between July 1971 and July 1977 were examined by haemagglutination-inhibition or single radial haemolysis methods for evidence of infection with influenza A (H3N2) viruses. A small proportion of swine sera collected in each year reacted in the tests but there was no evidence of infection in cattle. The significance of the findings is discussed, with particular reference to the seasonal fluctuations in the prevalence of antibody in swine observed during the period of the study, and their possible relevance to influenzal events in the human population. None of the sera tested had antibody to swine influenza strains (HSw1N1).

scholarly journals Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes

Diabetologia ◽  
2015 ◽  
Vol 58 (11) ◽  
pp. 2592-2595 ◽  
Author(s):  
Anita Kondrashova ◽  
Noora Nurminen ◽  
Maarit Patrikainen ◽  
Heini Huhtala ◽  
Jussi Lehtonen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Influenza A Virus ◽  
Pancreatic Islet ◽  
Influenza A ◽  
Islet Autoantibodies

scholarly journals Measurement of the mutation rates of animal viruses: influenza A virus and poliovirus type 1.

1986 ◽  
Vol 59 (2) ◽  
pp. 377-383 ◽  
Author(s):  
J D Parvin ◽  
A Moscona ◽  
W T Pan ◽  
J M Leider ◽  
P Palese
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Mutation Rates ◽  
Poliovirus Type

Mice with type 1 diabetes exhibit increased susceptibility to influenza A virus

2017 ◽  
Vol 113 ◽  
pp. 233-241 ◽  
Author(s):  
Caiyun Huo ◽  
Shouping Zhang ◽  
Siyi Zhang ◽  
Ming Wang ◽  
Peng Qi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Influenza A Virus ◽  
Influenza A ◽  
Increased Susceptibility

scholarly journals Hyperattenuated Recombinant Influenza A Virus Nonstructural-Protein-Encoding Vectors Induce Human Immunodeficiency Virus Type 1 Nef-Specific Systemic and Mucosal Immune Responses in Mice

2001 ◽  
Vol 75 (19) ◽  
pp. 8899-8908 ◽  
Author(s):  
Boris Ferko ◽  
Jana Stasakova ◽  
Sabine Sereinig ◽  
Julia Romanova ◽  
Dietmar Katinger ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Influenza Virus ◽  
Respiratory Tract ◽  
Influenza A Virus ◽  
Influenza A ◽  
Nonstructural Protein ◽  
T Cell Response ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT We have generated recombinant influenza A viruses belonging to the H1N1 and H3N2 virus subtypes containing an insertion of the 137 C-terminal amino acid residues of the human immunodeficiency virus type 1 (HIV-1) Nef protein into the influenza A virus nonstructural-protein (NS1) reading frame. These viral vectors were found to be genetically stable and capable of growing efficiently in embryonated chicken eggs and tissue culture cells but did not replicate in the murine respiratory tract. Despite the hyperattenuated phenotype of influenza/NS-Nef viruses, a Nef and influenza virus (nucleoprotein)-specific CD8+-T-cell response was detected in spleens and the lymph nodes draining the respiratory tract after a single intranasal immunization of mice. Compared to the primary response, a marked enhancement of the CD8+-T-cell response was detected in the systemic and mucosal compartments, including mouse urogenital tracts, if mice were primed with the H1N1 subtype vector and subsequently boosted with the H3N2 subtype vector. In addition, Nef-specific serum IgG was detected in mice which were immunized twice with the recombinant H1N1 and then boosted with the recombinant H3N2 subtype virus. These findings may contribute to the development of alternative immunization strategies utilizing hyperattenuated live recombinant influenza virus vectors to prevent or control infectious diseases, e.g., HIV-1 infection.

Isolation of an influenza A virus from domestic fowl in Great Britain

1982 ◽  
Vol 111 (18) ◽  
pp. 416-416 ◽  
Author(s):  
D. Alexander ◽  
J. Stuart
Keyword(s):  
Great Britain ◽  
Influenza A Virus ◽  
Domestic Fowl ◽  
Influenza A

scholarly journals Synthesis and Evaluation of Some Masked Phosphate Esters of the Anti-Herpesvirus Drug 882C (Netivudine) as Potential Antiviral Agents

1998 ◽  
Vol 9 (3) ◽  
pp. 233-243 ◽  
Author(s):  
C McGuigan ◽  
A Perry ◽  
CJ Yarnold ◽  
PW Sutton ◽  
D Lowe ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Virus Type ◽  
Influenza A ◽  
Relative Rate ◽  
Antiviral Agents ◽  
Phosphate Esters ◽  
Lead Target ◽  
Immunodeficiency Virus ◽  
Simplex Virus

A number of symmetric and asymmetric 5′-phosphate esters of the potent anti-varicellazoster virus (VZV) agent 1–(β-d-arabinofuranosyl)-5-prop-1-ynyluracil (882C; netivudine) were prepared as potential lipophilic, membrane-soluble prodrugs of the bioactive phosphate forms. The compounds were prepared by the base-catalysed coupling of various phosphorochloridates with the free nucleoside analogue. Compounds were fully characterized by a range of spectroscopic and analytical methods and were studied for their inhibition of several viruses in tissue culture. All of the phosphate esters were inactive against human cytomegalovirus, herpes simplex virus type 2, VZV, human immunodeficiency virus type 1 and influenza A virus (EC50 >100 μM) except the 5′-(4–nitrophenyl phenyl) phosphate, which inhibited influenza A virus. The relative rate of esterase-mediated hydrolysis of one of the lead target structures was measured in order to rationalize the poor antiviral action, and data were collected on possible metabolites in support of this analysis. Cell-specific esterases are implicated as key determinants of the antiviral potency of prodrugs of this type.

scholarly journals Inhibition of Human Immunodeficiency Virus Type 1 Replication prior to Reverse Transcription by Influenza Virus Stimulation

2000 ◽  
Vol 74 (10) ◽  
pp. 4505-4511 ◽  
Author(s):  
Ligia A. Pinto ◽  
Vesna Blazevic ◽  
Bruce K. Patterson ◽  
C. Mac Trubey ◽  
Matthew J. Dolan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Influenza A Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Reverse Transcription ◽  
Influenza A ◽  
Immunodeficiency Virus ◽  
Anti Hiv ◽  
Hiv 1

ABSTRACT It is now recognized that, in addition to drug-mediated therapies against human immunodeficiency virus type 1 (HIV-1), the immune system can exert antiviral effects via CD8+ T-cell-generated anti-HIV factors. This study demonstrates that (i) supernatants from peripheral blood mononuclear cells (PBMC) stimulated with influenza A virus inhibit replication of CCR5- and CXCR4-tropic HIV-1 isolates prior to reverse transcription; (ii) the HIV-suppressive supernatants can be generated by CD4- or CD8-depleted PBMC; (iii) this anti-HIV activity is partially due to alpha interferon (IFN-α), but not to IFN-γ, IFN-β, the β-chemokines MIP-1α, MIP-1β, and RANTES, or interleukin-16; (iv) the anti-HIV activity is generated equally well by PBMC cultured with either infectious or UV-inactivated influenza A virus; and (v) the antiviral activity can be generated by influenza A-stimulated PBMC from HIV-infected individuals. These findings represent a novel mechanism for inhibition of HIV-1 replication that differs from the previously described CD8 anti-HIV factors (MIP-1α, MIP-1β, RANTES, and CD8 antiviral factor).

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