Does the false‐negative rate for 1 or 2 negative sentinel nodes after neo‐adjuvant chemotherapy translate into a high local recurrence rate?

Abstract Background Sentinel lymph node biopsy (SLNB) acts as a vital role in the breast cancer surgery, and the identified number of sentinel nodes determines its accuracy to represent the status of axillae. There remain two tumor biopsy modes in breast cancer, preoperative and intraoperative biopsy. We compared the effect of the two different biopsies on the result of SLNB. Methods Patients with clinical stage T1-3, N0 tumor were enrolled in this study. 53% received preoperative tumor biopsy and 47% received intraoperative excisional biopsy. For search of the sentinel lymph node, patients received dual tracer injection. The number of SLNs detected and false negative rate were compared between groups. Results 204 patients were enrolled, 108 received preoperative tumor biopsy and 96 received intraoperative excisional biopsy. Among all the patients, 160 received ALND following SLNB. Preoperative tumor biopsy detected more SLNs than intraoperative biopsy (mean rank 113.87 vs. 90.9, p= 0.004). False negative rate in preoperative and intraoperative tumor biopsy was 3% and 18%, respectively. Conclusions Patients in preoperative tumor biopsy group could find more SLNs than intraoperative biopsy patients. False negative rate was also lower in preoperative biopsy group.

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Initial Local Excision for Clinical T1 Rectal Cancer Showed Comparable Overall Survival Despite High Local Recurrence Rate: A Propensity-Matched Analysis

Annals of Coloproctology ◽

10.3393/ac.2021.00479.0068 ◽

2021 ◽

Author(s):

Jong Hee Hyun ◽

Mohamed K. Alhanafy ◽

Hyoung-Chul Park ◽

Su Min Park ◽

Sung-Chan Park ◽

...

Keyword(s):

Rectal Cancer ◽

Overall Survival ◽

Local Recurrence ◽

Recurrence Rate ◽

Local Excision ◽

Local Recurrence Rate ◽

T1 Rectal Cancer ◽

High Local Recurrence Rate

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Can patient-, treatment- and pathology-related characteristics explain the high local recurrence rate following breast-conserving therapy in young patients?

European Journal of Cancer ◽

10.1016/s0959-8049(03)00123-0 ◽

2003 ◽

Vol 39 (7) ◽

pp. 932-944 ◽

Cited By ~ 133

Author(s):

C Vrieling ◽

L Collette ◽

A Fourquet ◽

W.J Hoogenraad ◽

J.-C Horiot ◽

...

Keyword(s):

Local Recurrence ◽

Recurrence Rate ◽

Local Recurrence Rate ◽

Young Patients ◽

Breast Conserving Therapy ◽

Patient Treatment ◽

High Local Recurrence Rate

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Is reduction of high local recurrence rate in young women possible?

European Journal of Cancer ◽

10.1016/s0959-8049(02)80406-3 ◽

2002 ◽

Vol 38 (11) ◽

pp. S126

Author(s):

H Bartelink

Keyword(s):

Local Recurrence ◽

Recurrence Rate ◽

Young Women ◽

Local Recurrence Rate ◽

High Local Recurrence Rate

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Anorectal gastrointestinal stromal tumors: a retrospective multicenter analysis of 15 cases emphasizing their high local recurrence rate and the need for standardized therapeutic approach

International Journal of Colorectal Disease ◽

10.1007/s00384-013-1655-3 ◽

2013 ◽

Vol 28 (8) ◽

pp. 1057-1064 ◽

Cited By ~ 13

Author(s):

Abbas Agaimy ◽

Nikolaos Vassos ◽

Bruno Märkl ◽

Norbert Meidenbauer ◽

Jens Köhler ◽

...

Keyword(s):

Local Recurrence ◽

Recurrence Rate ◽

Therapeutic Approach ◽

Gastrointestinal Stromal Tumors ◽

Local Recurrence Rate ◽

Stromal Tumors ◽

High Local Recurrence Rate ◽

Multicenter Analysis

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Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor

Case Reports in Dermatology ◽

10.1159/000444045 ◽

2016 ◽

Vol 8 (1) ◽

pp. 26-30 ◽

Cited By ~ 2

Author(s):

Kosuke Shido ◽

Taku Fujimura ◽

Aya Kakizaki ◽

Sadanori Furudate ◽

Masayuki Asano ◽

...

Keyword(s):

Case Report ◽

Local Recurrence ◽

Recurrence Rate ◽

Local Recurrence Rate ◽

Present Report ◽

Malignant Potential ◽

Immunomodulatory Effects ◽

High Local Recurrence Rate ◽

Mesenchymal Neoplasm ◽

Plexiform Fibrohistiocytic Tumor

Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206- tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT.

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Effects of Previous Surgery on the Detection of Sentinel Nodes in Women With Vulvar Cancer

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e31822dbe3c ◽

2011 ◽

Vol 21 (9) ◽

pp. 1679-1683 ◽

Cited By ~ 10

Author(s):

Tessa A. Ennik ◽

David G. Allen ◽

Ruud L.M. Bekkers ◽

Simon E. Hyde ◽

Peter T. Grant

Keyword(s):

Vulvar Cancer ◽

False Negative ◽

False Negative Rate ◽

Blue Dye ◽

Previous Surgery ◽

Detection Rates ◽

Reliable Technique ◽

Appearance Time ◽

Negative Rate ◽

Significant Difference

BackgroundThere is a growing interest to apply the sentinel node (SN) procedure in the treatment of vulvar cancer. Previous vulvar surgery might disrupt lymphatic patterns and thereby decrease SN detection rates, lengthen scintigraphic appearance time (SAT), and increase SN false-negative rate. The aims of this study were to evaluate the SN detection rates at the Mercy Hospital for Women in Melbourne and to investigate whether previous vulvar surgery affects SN detection rates, SAT, and SN false-negative rate.MethodsData on all patients with vulvar cancer who underwent an SN procedure (blue dye, technetium, or combined technique) from November 2000 to July 2010 were retrospectively collected.ResultsSixty-five SN procedures were performed. Overall detection rate was 94% per person and 80% per groin. Detection rates in the group of patients who underwent previous excision of the primary tumor were not lower compared with the group without previous surgery or with just an incisional biopsy. There was no statistical significant difference in SAT between the previous excision group and the other patients. None of the patients with a false-negative SN had undergone previous excision.ConclusionsResults indicate that previous excision of a primary vulvar malignancy does not decrease SN detection rates or increase SN false-negative rate. Therefore, the SN procedure appears to be a reliable technique in patients who have previously undergone vulvar surgery. Previous excision did not significantly lengthen SAT, but the sample size in this subgroup analysis was small.

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Temporal dynamics of viral load and false negative rate influence the levels of testing necessary to combat COVID-19 spread

Scientific Reports ◽

10.1038/s41598-021-88498-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Katherine F. Jarvis ◽

Joshua B. Kelley

Keyword(s):

Viral Load ◽

Temporal Dynamics ◽

Reproduction Number ◽

False Negative ◽

False Negative Rate ◽

Agent Based Model ◽

Agent Based ◽

Viral Spread ◽

Negative Rate

AbstractColleges and other organizations are considering testing plans to return to operation as the COVID-19 pandemic continues. Pre-symptomatic spread and high false negative rates for testing may make it difficult to stop viral spread. Here, we develop a stochastic agent-based model of COVID-19 in a university sized population, considering the dynamics of both viral load and false negative rate of tests on the ability of testing to combat viral spread. Reported dynamics of SARS-CoV-2 can lead to an apparent false negative rate from ~ 17 to ~ 48%. Nonuniform distributions of viral load and false negative rate lead to higher requirements for frequency and fraction of population tested in order to bring the apparent Reproduction number (Rt) below 1. Thus, it is important to consider non-uniform dynamics of viral spread and false negative rate in order to model effective testing plans.

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