Arabidopsis lysin motif/F‐box‐containing protein InLYP1 fine‐tunes glycine metabolism by degrading glycine decarboxylase GLDP2

2021 ◽  
Author(s):  
Jianhang Guo ◽  
Ben‐Qiang Gong ◽  
Jian‐Feng Li
Keyword(s):  
Glycine Decarboxylase ◽  
Glycine Metabolism

scholarly journals mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Rui Liu ◽  
Lin-Wen Zeng ◽  
Rong Gong ◽  
Fanen Yuan ◽  
Hong-Bing Shu ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Ubiquitin Ligase ◽  
Glycine Decarboxylase ◽  
Glycine Cleavage System ◽  
Sirtuin 3 ◽  
Post Translational Modifications ◽  
Mechanistic Target Of Rapamycin ◽  
Glycine Metabolism ◽  
Key Enzyme ◽  
Glycine Cleavage

AbstractGlycine decarboxylase (GLDC) is a key enzyme of glycine cleavage system that converts glycine into one-carbon units. GLDC is commonly up-regulated and plays important roles in many human cancers. Whether and how GLDC is regulated by post-translational modifications is unknown. Here we report that mechanistic target of rapamycin complex 1 (mTORC1) signal inhibits GLDC acetylation at lysine (K) 514 by inducing transcription of the deacetylase sirtuin 3 (SIRT3). Upon inhibition of mTORC1, the acetyltransferase acetyl-CoA acetyltransferase 1 (ACAT1) catalyzes GLDC K514 acetylation. This acetylation of GLDC impairs its enzymatic activity. In addition, this acetylation of GLDC primes for its K33-linked polyubiquitination at K544 by the ubiquitin ligase NF-X1, leading to its degradation by the proteasomal pathway. Finally, we find that GLDC K514 acetylation inhibits glycine catabolism, pyrimidines synthesis and glioma tumorigenesis. Our finding reveals critical roles of post-translational modifications of GLDC in regulation of its enzymatic activity, glycine metabolism and tumorigenesis, and provides potential targets for therapeutics of cancers such as glioma.

Glycine metabolism by plant mitochondria

1990 ◽  
Vol 80 (3) ◽  
pp. 487-491 ◽  
Author(s):  
David J. Oliver ◽  
Michel Neuburger ◽  
Jacques Bourguignon ◽  
Roland Douce
Keyword(s):  
Plant Mitochondria ◽  
Glycine Metabolism

scholarly journals Glycine Metabolism

1967 ◽  
Vol 242 (2) ◽  
pp. 301-305 ◽  
Author(s):  
Sigrid M. Klein ◽  
Richard D. Sagers
Keyword(s):  
Glycine Metabolism

scholarly journals Glycine Metabolism

1966 ◽  
Vol 241 (1) ◽  
pp. 206-209
Author(s):  
Sigrid M. Klein ◽  
Richard D. Sagers
Keyword(s):  
Glycine Metabolism

scholarly journals P-Protein of Glycine Decarboxylase from Flaveria pringlei

1994 ◽  
Vol 104 (3) ◽  
pp. 1077-1078 ◽  
Author(s):  
S. Kopriva ◽  
H. Bauwe
Keyword(s):  
Glycine Decarboxylase ◽  
P Protein

Intramitochondrial localisation of glycine decarboxylase in spinach leaves

1977 ◽  
Vol 78 (2) ◽  
pp. 483-491 ◽  
Author(s):  
A.L. Moore ◽  
C. Jackson ◽  
B. Halliwell ◽  
J.E. Dench ◽  
D.O. Hall
Keyword(s):  
Glycine Decarboxylase ◽  
Spinach Leaves
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