Weak D antigen expression caused by a novelRHDallele in Argentineans

Transfusion ◽  
2016 ◽  
Vol 56 (11) ◽  
pp. 2895-2896 ◽  
Author(s):  
Carolina Trucco Boggione ◽  
Melina Eliana Luján Brajovich ◽  
Ane Caroline Gaspardi ◽  
Emilia Sippert ◽  
Stella Maris Mattaloni ◽  
...  
Keyword(s):  
Antigen Expression ◽  
D Antigen

scholarly journals Missense RHD single nucleotide variants induce weakened D antigen expression by altering splicing and/or protein expression

Transfusion ◽  
2021 ◽  
Author(s):  
Loann Raud ◽  
Marlène Le Tertre ◽  
Léonie Vigneron ◽  
Chandran Ka ◽  
Gaëlle Richard ◽  
...  
Keyword(s):  
Protein Expression ◽  
Antigen Expression ◽  
Single Nucleotide Variants ◽  
Single Nucleotide ◽  
D Antigen

Variation in the level of Rh(D) antigen expression

Transfusion ◽  
1988 ◽  
Vol 28 (4) ◽  
pp. 397-398 ◽  
Author(s):  
AH Merry ◽  
C Hodson ◽  
S Moore
Keyword(s):  
Antigen Expression ◽  
D Antigen

scholarly journals Lack of Rhesus antigen expression by human committed erythroid progenitors

Blood ◽  
1983 ◽  
Vol 61 (3) ◽  
pp. 525-529 ◽  
Author(s):  
A Rearden ◽  
P Chiu
Keyword(s):  
Specific Antigen ◽  
Antigen Expression ◽  
Inhibitory Effect ◽  
Significant Inhibition ◽  
Specific Cell ◽  
Erythroid Progenitors ◽  
Drug Induced ◽  
Erythroid Progenitor ◽  
Differentiation Marker ◽  
D Antigen

Abstract The D antigen of the Rhesus blood group, an erythroid-specific cell surface marker, is expressed by all morphologically recognizable human nucleated red blood cell precursors including, in low density, the pronormoblast. The object of the present study was to determine the expression of the D antigen by committed erythroid progenitors. Under conditions that produced complete inhibition of BFU-E and CFU-E by known cytotoxic antisera, no significant inhibition was produced by anti-D. Use of anti-human IgG (rabbit) to increase sensitivity and trypsinization to reveal cryptic Rh determinants were both without inhibitory effect. Erythroid bursts and colonies grew normally in methylcellulose that contained anti-D. The addition of anti-D to day 7 BFU-E did not inhibit their proliferation to mature bursts at day 14. These results suggest that the D antigen is not expressed by human committed erythroid progenitor cells. The D antigen is therefore an erythroid-specific differentiation marker, rather than an erythroid- lineage-specific antigen. The development of expression of the D antigen during erythropoiesis parallels that of band 3 protein, to which anti-D has been reported to bind. Lack of Rh expression by committed erythroid progenitors is consistent with the rarity of red cell aplasia in Rhesus hemolytic disease of the newborn and in idiopathic and drug-induced autoimmune hemolytic anemia in which the autoantibodies have apparent Rh specificity. These results imply that Rh compatibility is not a contraindication to human bone marrow transplantation.

Some Observations on D Antigen Expression of D-Positive and ‘Weak D-Positive’ Red Cells as Assessed by Flow Cytometry

Vox Sanguinis ◽  
1995 ◽  
Vol 69 (2) ◽  
pp. 154-154
Author(s):  
Pier Luigi Tazzari ◽  
Andrea Bontadini ◽  
Daniela Belletti ◽  
Franco Malferrari ◽  
Roberto Conte
Keyword(s):  
Flow Cytometry ◽  
Antigen Expression ◽  
Red Cells ◽  
D Antigen

scholarly journals Lack of Rhesus antigen expression by human committed erythroid progenitors

Blood ◽  
1983 ◽  
Vol 61 (3) ◽  
pp. 525-529
Author(s):  
A Rearden ◽  
P Chiu
Keyword(s):  
Specific Antigen ◽  
Antigen Expression ◽  
Inhibitory Effect ◽  
Significant Inhibition ◽  
Specific Cell ◽  
Erythroid Progenitors ◽  
Drug Induced ◽  
Erythroid Progenitor ◽  
Differentiation Marker ◽  
D Antigen

The D antigen of the Rhesus blood group, an erythroid-specific cell surface marker, is expressed by all morphologically recognizable human nucleated red blood cell precursors including, in low density, the pronormoblast. The object of the present study was to determine the expression of the D antigen by committed erythroid progenitors. Under conditions that produced complete inhibition of BFU-E and CFU-E by known cytotoxic antisera, no significant inhibition was produced by anti-D. Use of anti-human IgG (rabbit) to increase sensitivity and trypsinization to reveal cryptic Rh determinants were both without inhibitory effect. Erythroid bursts and colonies grew normally in methylcellulose that contained anti-D. The addition of anti-D to day 7 BFU-E did not inhibit their proliferation to mature bursts at day 14. These results suggest that the D antigen is not expressed by human committed erythroid progenitor cells. The D antigen is therefore an erythroid-specific differentiation marker, rather than an erythroid- lineage-specific antigen. The development of expression of the D antigen during erythropoiesis parallels that of band 3 protein, to which anti-D has been reported to bind. Lack of Rh expression by committed erythroid progenitors is consistent with the rarity of red cell aplasia in Rhesus hemolytic disease of the newborn and in idiopathic and drug-induced autoimmune hemolytic anemia in which the autoantibodies have apparent Rh specificity. These results imply that Rh compatibility is not a contraindication to human bone marrow transplantation.

HLA-D antigen expression and Langerhans' cell infiltrates in thyroid tumors

1995 ◽  
Vol 6 (3) ◽  
pp. 197-206 ◽  
Author(s):  
Simon J. Raphael ◽  
Sylvia L. Asa
Keyword(s):  
Antigen Expression ◽  
Langerhans Cell ◽  
Thyroid Tumors ◽  
D Antigen

scholarly journals RHD del28Phe (DMW) encoded by a novel in‐frame deletion resulting in reduced D antigen expression

Transfusion ◽  
2019 ◽  
Vol 59 (9) ◽  
pp. 3033-3034
Author(s):  
Eva Maria Matzhold ◽  
Helene Polin ◽  
Günther F. Körmöczi ◽  
Susanne Macher ◽  
Marlies Schönbacher ◽  
...  
Keyword(s):  
Antigen Expression ◽  
D Antigen

Some Observations on D Antigen Expression of D-Positive and ‘Weak D-Positive’ Red Cells as Assessed by Flow Cytometry

Vox Sanguinis ◽  
1995 ◽  
Vol 69 (2) ◽  
pp. 152-153 ◽  
Author(s):  
M. Nelson ◽  
L.A. Barrow ◽  
H. Popp ◽  
J. Gibson
Keyword(s):  
Flow Cytometry ◽  
Antigen Expression ◽  
Red Cells ◽  
D Antigen

Effects of modulating erythrocyte membrane cholesterol on Rho(D) antigen expression

1980 ◽  
Vol 95 (2) ◽  
pp. 887-893 ◽  
Author(s):  
Mukul K. Basu ◽  
Michael Flamm ◽  
David Schachter ◽  
John F. Bertles ◽  
Alice Maniatis
Keyword(s):  
Erythrocyte Membrane ◽  
Antigen Expression ◽  
Membrane Cholesterol ◽  
D Antigen
Sign in / Sign up

Export Citation Format

Share Document