Prenatal selection of cord blood donors according to the estimated fetal weight percentile and new approaches; results of a prospective cohort study

Transfusion ◽  
2020 ◽  
Author(s):  
Lin Xinxin ◽  
Francesca Crovetto ◽  
Alba González ◽  
Daniel Cuadras ◽  
Mar Sanchez ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cord Blood ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Blood Donors ◽  
Fetal Weight ◽  
New Approaches ◽  
Weight Percentile ◽  
Estimated Fetal Weight ◽  
Selection Of

Estimated fetal weight percentile as a tool to predict collection of cord blood units with higher cellular content: implications for prenatal selection of cord blood donors

Transfusion ◽  
2018 ◽  
Vol 58 (7) ◽  
pp. 1732-1738 ◽  
Author(s):  
Xinxin Lin ◽  
Marta Torrabadella ◽  
Lluís Amat ◽  
Susana Gómez ◽  
Carmen Azqueta ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Donors ◽  
Fetal Weight ◽  
Cellular Content ◽  
Weight Percentile ◽  
Estimated Fetal Weight ◽  
Selection Of

scholarly journals 976. Clostridium difficile Colonization Molecular Epidemiology and Anti-toxin Serological Responses in Healthy Infants: A Prospective Cohort Study

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S39-S40
Author(s):  
Larry Kociolek ◽  
Ciaran P Kelly ◽  
Robyn Espinosa ◽  
Maria Budz ◽  
Aakash Balaji ◽  
...  
Keyword(s):  
Cohort Study ◽  
Molecular Epidemiology ◽  
Cord Blood ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Medical Officer ◽  
Humoral Immune ◽  
Healthy Infants ◽  
Unrelated Cord Blood ◽  
Research Grant

Abstract Background Infant C. difficile colonization is common, but the molecular epidemiology and immunologic consequences of colonization are poorly understood. Methods In this prospective cohort study of healthy infants, serial stools collected between 1–2 and 9–12 month olds were tested for glutamate dehydrogenase (detects nontoxigenic or toxigenic C. difficile [TCD]), tcdB PCR (detects TCD), and cultured for C. difficile. Isolates underwent whole genome sequencing and multilocus sequence typing (MLST). Clonal strains were identified by single nucleotide variant (SNV) analysis. TCD was confirmed by BLAST identification of tcdA/tcdB. Serum collected at 9–12 month olds underwent ELISA for measurement of IgA, IgG, and IgM against TCD toxins A and B. For comparison, anti-toxin IgG was measured in cord blood of 50 consecutive full-term deliveries (unrelated to study infants). Arbitrary ELISA units were compared by Wilcoxon rank-sum test. Results Among 32 infants, 16 (50%) had at least one TCD+ stool, 12 of whom were colonized at least 1 m prior to serology measurements (Figures 1 and 2). A variety of STs were identified, and evidence of putative in-home (enrolled siblings) and outpatient clinic transmission was identified (Figure 3). Infants with TCD colonization had significantly greater levels of anti-toxin IgA and IgG compared with non-colonized infants and IgG compared with unrelated cord blood (Table 1). Conclusion Infant C. difficile colonization is a dynamic process with variable strain types and duration. Outpatient clinics may be a C. difficile reservoir for some patients. TCD colonization is associated with a humoral immune response against toxins A and B, but whether natural TCD immunization protects against CDI later in life requires further investigation. Disclosures L. Kociolek, Alere/Techlab: Investigator, Research support. C. P. Kelly, Actelion: Consultant, Consulting fee. Artugen: Consultant, Consulting fee. Facile: Consultant, Consulting fee. GSK: Consultant, Consulting fee. MSD: Consultant, Consulting fee. Seres: Consultant, Consulting fee. Summit: Consultant, Consulting fee. Vedanta: Consultant, Consulting fee. D. N. Gerding, Merck: Scientific Advisor, Consulting fee. Actelion: Scientific Advisor, Consulting fee. DaVolterra: Scientific Advisor, Consulting fee. Summit: Scientific Advisor, Consulting fee. Rebiotix: Medical Officer and Scientific Advisor, Consulting fee. Pfizer: Consultant, Consulting fee. MGB Pharma: Consultant, Consulting fee. sanofi pasteur: Consultant, Consulting fee. Seres: Investigator, Research grant. CDC: Investigator, Research grant. US Dept VA: Investigator, Research grant. Treatment/Prevention of C. difficile: Patent Holder, no license or royalties.

Fetal Exposure to Secondhand Tobacco Smoke Assessed by Maternal Self-reports and Cord Blood Cotinine: Prospective Cohort Study in Krakow

2008 ◽  
Vol 13 (3) ◽  
pp. 415-423 ◽  
Author(s):  
Wieslaw Jedrychowski ◽  
Frederica Perera ◽  
Elzbieta Mroz ◽  
Susan Edwards ◽  
Elzbieta Flak ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cord Blood ◽  
Prospective Cohort Study ◽  
Tobacco Smoke ◽  
Prospective Cohort ◽  
Fetal Exposure ◽  
Self Reports ◽  
Secondhand Tobacco Smoke

Associations of maternal personal exposure to air pollution on fetal weight and fetoplacental Doppler: A prospective cohort study

2016 ◽  
Vol 62 ◽  
pp. 9-17 ◽  
Author(s):  
Mariana A. Carvalho ◽  
Lisandra S. Bernardes ◽  
Karen Hettfleisch ◽  
Luciana D.M. Pastro ◽  
Sandra E. Vieira ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Personal Exposure ◽  
Fetal Weight

scholarly journals Cord Blood Leptin and Adiponectin as Predictors of Adiposity in Children at 3 Years of Age: A Prospective Cohort Study

PEDIATRICS ◽  
2009 ◽  
Vol 123 (2) ◽  
pp. 682-689 ◽  
Author(s):  
C. S. Mantzoros ◽  
S. L. Rifas-Shiman ◽  
C. J. Williams ◽  
J. L. Fargnoli ◽  
T. Kelesidis ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cord Blood ◽  
Prospective Cohort Study ◽  
Prospective Cohort

scholarly journals Combined Influence of Gestational Weight Gain and Estimated Fetal Weight on Risk Assessment for Small- or Large-for-Gestational-Age Birth Weight: A Prospective Cohort Study

2017 ◽  
Vol 37 (4) ◽  
pp. 935-940 ◽  
Author(s):  
Sarah J. Pugh ◽  
Stefanie N. Hinkle ◽  
Sungduk Kim ◽  
Paul S. Albert ◽  
Roger Newman ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cohort Study ◽  
Weight Gain ◽  
Birth Weight ◽  
Prospective Cohort Study ◽  
Gestational Age ◽  
Prospective Cohort ◽  
Large For Gestational Age ◽  
Gestational Weight ◽  
Estimated Fetal Weight

Galectin-3 detection on large-needle aspiration biopsy improves preoperative selection of thyroid nodules: A prospective cohort study

2009 ◽  
Vol 42 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Angelo Carpi ◽  
Giuseppe Rossi ◽  
Giancarlo Di Coscio ◽  
Giorgio Iervasi ◽  
Andrea Nicolini ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Preoperative Selection ◽  
Galectin 3 ◽  
Needle Aspiration Biopsy ◽  
Selection Of
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