Comparison of mitotic index and Ki67 index in the prognostication of canine cutaneous mast cell tumours

2013 ◽  
Vol 13 (2) ◽  
pp. 143-150 ◽  
Author(s):  
D. Berlato ◽  
S. Murphy ◽  
P. Monti ◽  
J. Stewart ◽  
J. R. Newton ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mitotic Index ◽  
Ki67 Index ◽  
Cutaneous Mast Cell

Galectin-3 immunolabelling correlates with BCL2 expression in canine cutaneous mast cell tumours

2021 ◽  
Author(s):  
Thiago Henrique M. Vargas ◽  
Camila N. Barra ◽  
Lidia H. Pulz ◽  
Greice C. Huete ◽  
Karine G. Cadrobbi ◽  
...  
Keyword(s):  
Mast Cell ◽  
Prognostic Marker ◽  
Clinical Presentation ◽  
Prognostic Indicator ◽  
Biological Processes ◽  
Ki67 Index ◽  
Galectin 3 ◽  
Cutaneous Mast Cell ◽  
Related Proteins ◽  
Bcl2 Expression

AbstractMast cell tumour (MCT) is the most frequent skin neoplasm in dogs. These tumours are characterised by variable behaviour and clinical presentation that make prognosis an important and challenging task in the veterinary practice. Galectin-3 (Gal-3) is known to influence several biological processes that are important in the cancer context and has been described as a prognostic marker for several human cancers. The aim of the present work was to characterise Gal-3 immunolabelling in canine cutaneous MCTs and to investigate its value as a prognostic marker for the disease. Thirty-four random cases of canine cutaneous MCT that were surgically treated with wide margins were included in this study. Gal-3 expression was evaluated using immunohistochemistry and the results were compared with the expression of apoptosis-related proteins, Ki67 index, histopathological grades, mortality due to the disease and post-surgical survival. The majority of the MCTs (65.8%) were positive for Gal-3. Gal-3 immunolabelling was variable among the samples (2.7%–86.8% of the neoplastic cells). The protein was located in the cytoplasm or in the cytoplasm and the nucleus. Gal-3 positivity was correlated with BCL2 expression (P < 0.001; r = 0.604), but not with Ki67 and BAX. No significant differences were detected between histological grades or in the survival analysis. Gal-3 expression correlates with BCL2 expression in MCTs. Although an efficient marker for several human neoplasms, the results presented herein suggest that Gal-3 immunolabelling is not an independent prognostic indicator for this disease.

Association of Ki67 index with prognosis for intermediate-grade canine cutaneous mast cell tumours*

2008 ◽  
Vol 6 (4) ◽  
pp. 268-274 ◽  
Author(s):  
G. A. Maglennon ◽  
S. Murphy ◽  
V. Adams ◽  
J. Miller ◽  
K. Smith ◽  
...  
Keyword(s):  
Mast Cell ◽  
Ki67 Index ◽  
Intermediate Grade ◽  
Cutaneous Mast Cell

Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors

2007 ◽  
Vol 44 (3) ◽  
pp. 335-341 ◽  
Author(s):  
E. M. Romansik ◽  
C. M. Reilly ◽  
P. H. Kass ◽  
P. F. Moore ◽  
C. A. London
Keyword(s):  
Mast Cell ◽  
Mitotic Index ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell

scholarly journals Nanog Expression and Proliferation Indices in Canine Cutaneous Mast Cell Tumors

2018 ◽  
Vol 55 (6) ◽  
pp. 849-852
Author(s):  
Julia A. Joselevitch ◽  
Camila N. Barra ◽  
Thiago Henrique M. Vargas ◽  
Lidia H. Pulz ◽  
Adriana T. Nishiya ◽  
...  
Keyword(s):  
Mast Cell ◽  
Histological Grade ◽  
Clinical Information ◽  
Ki67 Index ◽  
Mast Cell Tumors ◽  
Proliferation Indices ◽  
Nanog Expression ◽  
Mast Cell Tumor ◽  
Wide Range ◽  
Cutaneous Mast Cell

Mast cell tumors are one of the most frequent skin tumors in dogs. Treatment decisions often depend on a wide range of clinical information and the main criteria for prognostic formulation are histological grade, mitotic count, Ki67 index, and KIT immunostaining pattern. NANOG is a pluripotency factor expressed by normal and cancer stem cells, which is a prognostic marker and a potential therapeutic target for several human tumors. In the present study, mast cell tumor samples from 41 dogs were evaluated for NANOG and Ki67 by immunohistochemistry. All samples were positive for NANOG but its expression was not correlated with Ki67 index and no significant differences were found with respect to histopathological grades, disease-related mortality, or survival. Our results suggest that, although related to pluripotency, NANOG expression does not correlate with proliferative activity, and is not a reliable prognostic factor for canine cutaneous mast cell tumors.

scholarly journals Prevalence and epidemiological and histopathological features of canine cutaneous mast cell tumours in Uberlândia, Brazil

2017 ◽  
Vol 86 (2) ◽  
pp. 189-193
Author(s):  
Marcelo Carrijo Costa ◽  
Ana Letícia Daher Aprígio Silva ◽  
Thais Almeida Moreira ◽  
Lígia Fernandes Gundim ◽  
Alessandra Aparecida Medeiros-Ronchi
Keyword(s):  
Mast Cell ◽  
Mitotic Index ◽  
Epidemiological Data ◽  
Skin Neoplasms ◽  
Cell Tumour ◽  
Histological Classification ◽  
Mast Cell Tumour ◽  
Grade Ii ◽  
Cutaneous Mast Cell

This study aimed to perform a retrospective survey of canine cutaneous mast cell tumours at the Veterinary Hospital of the Federal University of Uberl‰ndia, as well as to gather epidemiological data, such as breed, age, sex, and location. We also sought to histopathologically classify and characterize the mast cell tumours. Mast cell tumour was the most common neoplasm, accounting for 16.78% of skin neoplasms. In terms of the epidemiological data, the mast cell tumours did not show sexual predilection. Animals aged 9 to 12 years were the most affected (44.14%). The genitalia were the most frequent location (28.15%), and mongrel dogs showed the highest prevalence (30.43%), followed by boxers (22.61%). A total of 92 slides were classified; grade II was most frequently seen (61.96%). Statistically, injuries such as necrosis, oedema, and haemorrhage were not related with histological classification (P > 0.05). Finally, the mitotic index was related to tumour grade (P < 0.05), and can act as an instrument for histological classification of these tumours. Mast cell tumour is the most common neoplasm in dogs, with no sex predilection. Contrary to what was expected, oedema, necrosis and haemorrhage do not increase according to graduation and can be seen in all classifications. Mitotic index is the best indicator to classify these neoplasms.

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