Treatment of murine partial thickness scald injuries with multipotent adult progenitor cells decreases inflammation and promotes angiogenesis leading to improved burn injury repair

2021 ◽  
Author(s):  
Parinaz Ahangar ◽  
Stuart J. Mills ◽  
Louise E. Smith ◽  
Xanthe L. Strudwick ◽  
Anthony E. Ting ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Burn Injury ◽  
Multipotent Adult Progenitor Cells ◽  
Injury Repair ◽  
Partial Thickness

scholarly journals Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells

2013 ◽  
Vol 91 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Sandra A Jacobs ◽  
Valerie D Roobrouck ◽  
Catherine M Verfaillie ◽  
Stefaan W Van Gool
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Progenitor Cells ◽  
Human Mesenchymal Stem Cells ◽  
Multipotent Adult Progenitor Cells

Effects of Serum From Rats With Combined Radiation-Burn Injury on the Growth of Hematopoietic Progenitor Cells

2007 ◽  
Vol 62 (1) ◽  
pp. 193-198 ◽  
Author(s):  
Xin-Ze Ran ◽  
Yong-Ping Su ◽  
Zhao-Wen Zong ◽  
Chao-Hua Guo ◽  
Huai-En Zheng ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Burn Injury ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor

scholarly journals Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury

2016 ◽  
Vol 22 ◽  
pp. 1903-1909 ◽  
Author(s):  
Umit Ozcelik ◽  
Yahya Ekici ◽  
Huseyin Yuce Bircan ◽  
Cem Aydogan ◽  
Suna Turkoglu ◽  
...  
Keyword(s):  
Burn Injury ◽  
Platelet Rich Plasma ◽  
Partial Thickness ◽  
Partial Thickness Burn

scholarly journals miRNAs as Regulators of the Early Local Response to Burn Injuries

2021 ◽  
Vol 22 (17) ◽  
pp. 9209
Author(s):  
Ines Foessl ◽  
Christoph Walter Haudum ◽  
Ivan Vidakovic ◽  
Ruth Prassl ◽  
Joakim Franz ◽  
...  
Keyword(s):  
Early Phase ◽  
Target Genes ◽  
Burn Injury ◽  
Ex Vivo ◽  
Expression Patterns ◽  
Treatment Success ◽  
Burn Injuries ◽  
Specific Gene ◽  
Partial Thickness ◽  
Partial Thickness Burn

In burn injuries, risk factors and limitations to treatment success are difficult to assess clinically. However, local cellular responses are characterized by specific gene-expression patterns. MicroRNAs (miRNAs) are single-stranded, non-coding RNAs that regulate mRNA expression on a posttranscriptional level. Secreted through exosome-like vesicles (ELV), miRNAs are intracellular signalers and epigenetic regulators. To date, their role in the regulation of the early burn response remains unclear. Here, we identified 43 miRNAs as potential regulators of the early burn response through the bioinformatics analysis of an existing dataset. We used an established human ex vivo skin model of a deep partial-thickness burn to characterize ELVs and miRNAs in dermal interstitial fluid (dISF). Moreover, we identified miR-497-5p as stably downregulated in tissue and dISF in the early phase after a burn injury. MiR-218-5p and miR-212-3p were downregulated in dISF, but not in tissue. Target genes of the miRNAs were mainly upregulated in tissue post-burn. The altered levels of miRNAs in dISF of thermally injured skin mark them as new biomarker candidates for burn injuries. To our knowledge, this is the first study to report miRNAs altered in the dISF in the early phase of deep partial-thickness burns.

Multipotent Adult Progenitor Cells (MAPC) contribute to hepatocarcinoma neovasculature

2007 ◽  
Vol 364 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Miguel Barajas ◽  
Federico Franchi ◽  
Carlos Clavel ◽  
Xabier L. Aranguren ◽  
M. Gabriela Kramer ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Multipotent Adult Progenitor Cells
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