VIRTUAL TRIAL AND MONTE CARLO ANALYSIS OF MODEL-BASED GLYCAEMIC CONTROL PROTOCOL WITH REDUCED NURSING EFFORT

Tight glycaemic management has been shown to be beneficial to the outcomes of patients receiving intensive care. However, tight glycaemic control (TGC) protocol within intensive care (ICU) comes with a high clinical demand, namely high nursing effort. Thus, there is a need for a protocol that is safe, effective, robust, yet does not require a high nursing effort. A less intensive protocol is designed to use a combination of subcutaneous long-acting insulin (glargine) with IV insulin bolus and only requires blood glucose (BG) measurements every 4 hours while maintaining measurement within 4.0-6.1 mmol/L.

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Contrasting weight changes with LY2605541, a novel long-acting insulin, and insulin glargine despite similar improved glycaemic control in T1DM and T2DM

Diabetes Obesity and Metabolism ◽

10.1111/dom.12223 ◽

2013 ◽

Vol 16 (4) ◽

pp. 351-356 ◽

Cited By ~ 15

Author(s):

S. J. Jacober ◽

J. Rosenstock ◽

R. M. Bergenstal ◽

M. J. Prince ◽

Y. Qu ◽

...

Keyword(s):

Glycaemic Control ◽

Insulin Glargine ◽

Weight Changes ◽

Acting Insulin ◽

Long Acting ◽

Improved Glycaemic Control

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Uncertainties in the measurement of blood glucose in paediatric intensive care: implications for clinical trials of tight glycaemic control

Intensive Care Medicine ◽

10.1007/s00134-011-2302-5 ◽

2011 ◽

Vol 37 (9) ◽

pp. 1517-1524 ◽

Cited By ~ 4

Author(s):

Helen Hill ◽

Paul Baines ◽

Paul Barton ◽

Paul Newland ◽

Dianne Terlouw ◽

...

Keyword(s):

Clinical Trials ◽

Intensive Care ◽

Blood Glucose ◽

Glycaemic Control ◽

Paediatric Intensive Care ◽

Tight Glycaemic Control

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Acylated-based long-acting insulin analogues: Is “misfolding” the problem? Commentary letter on Hamasaki H and Yanai H. The switching from insulin glargine to insulin degludec reduced HbA1c, daily insulin doses and anti-insulin antibody in anti-insulin antibody-positive subjects with type 1 diabetes

Diabetes & Metabolism ◽

10.1016/j.diabet.2014.10.001 ◽

2014 ◽

Vol 40 (6) ◽

pp. 483-484 ◽

Cited By ~ 1

Author(s):

L. Monnier ◽

C. Colette ◽

D. Owens

Keyword(s):

Type 1 Diabetes ◽

Insulin Glargine ◽

Insulin Analogues ◽

Insulin Degludec ◽

Insulin Antibody ◽

Daily Insulin ◽

Acting Insulin ◽

Long Acting

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Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo

Diabetes Care ◽

10.2337/diacare.23.5.644 ◽

2000 ◽

Vol 23 (5) ◽

pp. 644-649 ◽

Cited By ~ 333

Author(s):

L. Heinemann ◽

R. Linkeschova ◽

K. Rave ◽

B. Hompesch ◽

M. Sedlak ◽

...

Keyword(s):

Insulin Glargine ◽

Insulin Analog ◽

Nph Insulin ◽

Acting Insulin ◽

Analog Insulin ◽

Long Acting ◽

Action Profile

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Lower Glucose Variability and Hypoglycemia Measured by Continuous Glucose Monitoring With Novel Long-Acting Insulin LY2605541 Versus Insulin Glargine

Diabetes Care ◽

10.2337/dc12-2621 ◽

2013 ◽

Vol 37 (3) ◽

pp. 659-665 ◽

Cited By ~ 22

Author(s):

Richard M. Bergenstal ◽

Julio Rosenstock ◽

Edward J. Bastyr ◽

Melvin J. Prince ◽

Yongming Qu ◽

...

Keyword(s):

Insulin Glargine ◽

Continuous Glucose Monitoring ◽

Glucose Monitoring ◽

Glucose Variability ◽

Acting Insulin ◽

Lower Glucose ◽

Long Acting

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The influence of strict control on diabetic complications

Acta Endocrinologica ◽

10.1530/acta.0.110s057 ◽

1985 ◽

Vol 110 (4_Suppl) ◽

pp. S57-S60 ◽

Cited By ~ 6

Author(s):

Kristian F. Hanssen ◽

Knut Dahl-Jørgensen ◽

Olaf Brinchmann-Hansen ◽

_ _

Keyword(s):

Blood Glucose ◽

Diabetic Complications ◽

Blood Glucose Control ◽

Response Duration ◽

Proliferative Retinopathy ◽

C Peptide ◽

Acting Insulin ◽

Strict Control ◽

Long Acting ◽

Retinal Response

Abstract. We studied 45 IDDM without c-peptide response, duration 7-22 years, without proliferative retinopathy. After 2 months run-in period, they were randomly assigned to: (P) 15 received CSII: (C) 15 received muliple s.c. injections via butterfly 5-6x daily;: (M) 15 received twice daily mixed rapid and long acting insulin. All groups improved blood glucose control in the run-in period (p<0.0001). After change of treatment (P) and (M) improved further (p<0.01) but (C) was unchanged. GFR was supranormal and decreased in (P) and (M). No regression of retinopathy was shown in any group. One in (P) had transient florid pre-proliferative retinopathy which regressed spontaneously without laser treatment. We conclude that retinal response to strict control is complex. A transient deterioration may been seen.

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