scholarly journals Bilateral regional extracranial blood flow regulation to hypoxia and unilateral duplex ultrasound measurement error

2021 ◽  
Author(s):  
Alexander T. Friend ◽  
Matthew. Rogan ◽  
Gabriella M. K. Rossetti ◽  
Justin S. Lawley ◽  
Paul G. Mullins ◽  
...  
2014 ◽  
Vol 306 (10) ◽  
pp. R747-R751 ◽  
Author(s):  
Shigehiko Ogoh ◽  
Romain Lericollais ◽  
Ai Hirasawa ◽  
Sadayoshi Sakai ◽  
Hervé Normand ◽  
...  

The present study examined to what extent an acute bout of hypotension influences blood flow in the external carotid artery (ECA) and the corresponding implications for blood flow regulation in the internal carotid artery (ICA). Nine healthy male participants were subjected to an abrupt decrease in arterial pressure via the thigh-cuff inflation-deflation technique. Duplex ultrasound was employed to measure beat-to-beat ECA and ICA blood flow. Compared with the baseline normotensive control, acute hypotension resulted in a heterogeneous blood flow response. ICA blood flow initially decreased following cuff release and then returned quickly to baseline levels. In contrast, the reduction in ECA blood flow persisted for 30 s following cuff release. Thus, the contribution of common carotid artery blood flow to the ECA circulation decreased during acute hypotension (−10 ± 4%, P < 0.001). This finding suggests that a preserved reduction in ECA blood flow, as well as dynamic cerebral autoregulation likely prevent a further decrease in intracranial blood flow during acute hypotension. The peripheral vasculature of the ECA may, thus, be considered an important vascular bed for intracranial cerebral blood flow regulation.


1989 ◽  
Vol 8 (3) ◽  
pp. 143-148 ◽  
Author(s):  
S M Otis ◽  
M E Rossman ◽  
P A Schneider ◽  
M P Rush ◽  
E B Ringelstein

2019 ◽  
Vol 597 (5) ◽  
pp. 1401-1417 ◽  
Author(s):  
Charmain A. Fernando ◽  
Aaron M. Pangan ◽  
DDW Cornelison ◽  
Steven S. Segal

2018 ◽  
Vol 24 (C) ◽  
pp. 16 ◽  
Author(s):  
Thessa I.M. Hilgenkamp ◽  
Sang Ouk Wee ◽  
Elizabeth C. Schroeder ◽  
Tracy Baynard ◽  
Bo Fernhall

2014 ◽  
Vol 116 (6) ◽  
pp. 703-705 ◽  
Author(s):  
Aleksander S. Golub ◽  
Roland N. Pittman

1985 ◽  
Vol 249 (3) ◽  
pp. H540-H546 ◽  
Author(s):  
M. J. Rubin ◽  
H. G. Bohlen

The effect of chronic, severe diabetes mellitus on the morphology, blood flow regulation, and tissue PO2 of the cerebral cortex was evaluated in adult rats. The arterioles of the diabetic animals were enlarged in terms of both lumen diameter and vessel wall area. Although resting blood flow in the diabetic rats was greater than in the normal rats, the autoregulation of cerebral blood flow was very good within an arterial pressure range of 40-150 mmHg, just as in normal rats. The resting tissue PO2 in diabetic rats was 14.9 +/- 0.5 (SEM) compared with 12.7 +/- 0.6 mmHg in normal animals and in both groups remained at or near the resting PO2 at arterial pressures from 40 to 150 mmHg. There was no apparent loss of arterioles on the cortex surface or change in length of individual arterioles in diabetic animals but there was a 20-30% decrease in the number of venules and no change in the length of individual venules. These data indicate that although the arteriolar morphology and number of venules change in the brain during diabetes, physiological function in terms of tissue PO2 and blood flow regulation is maintained within normal limits.


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