Profoundly lower muscle mass and rate of contractile protein synthesis in boys with Duchenne muscular dystrophy

2021 ◽  
Author(s):  
William J. Evans ◽  
Mahalakshmi Shankaran ◽  
Edward C. Smith ◽  
Carl Morris ◽  
Edna Nyangau ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Muscle Mass ◽  
Contractile Protein

scholarly journals Decrease in the Rate of Protein Synthesis by Polysomes from Cultured Fibroblasts of Patients and Carriers with Duchenne Muscular Dystrophy

1979 ◽  
Vol 6 (3) ◽  
pp. 355-358 ◽  
Author(s):  
M. Boulé ◽  
M. Vanasse ◽  
L. Brakier-Gingras
Keyword(s):  
Protein Synthesis ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Wheat Germ ◽  
Fibroblast Cells ◽  
Wheat Germ Extract ◽  
Cultured Fibroblasts ◽  
Normal Controls

SUMMARY:Polysomes extracted from cultured fibroblast cells isolated from patients with Duchenne muscular dystrophy (DMD), carriers of the disease, and normal controls were used for in vitro measurement of protein synthesis in a wheat germ extract system. It was observed that polysomes from patients and carriers (seven of each aged 17 years or older) exhibited a 3-fold and a 1.5-fold decrease in the rate of protein synthesis, respectively, as compared with controls. These results are discussed with a view to developing a sensitive and easily available assay for the detection of DMD carriers.

Measurement of skeletal muscle mass in Duchenne muscular dystrophy: use of 24-h creatinine excretion

2003 ◽  
Vol 40 (0) ◽  
pp. s290-s292 ◽  
Author(s):  
D. Franciotta ◽  
M. C. Zanardi ◽  
L. Albertotti ◽  
S. Orcesi ◽  
A. Berardinelli ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Creatinine Excretion

scholarly journals Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy

2011 ◽  
Vol 178 (3) ◽  
pp. 1287-1297 ◽  
Author(s):  
Emidio E. Pistilli ◽  
Sasha Bogdanovich ◽  
Marcus D. Goncalves ◽  
Rexford S. Ahima ◽  
Jennifer Lachey ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Mouse Model ◽  
Muscle Mass ◽  
Mdx Mouse ◽  
And Function
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