scholarly journals Altered visual and haptic verticality perception in posterior cortical atrophy and Alzheimer's disease

2021 ◽  
Author(s):  
Brian L Day ◽  
Dilek Ocal ◽  
Amy Peters ◽  
Matthew J Bancroft ◽  
David Cash ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

Difficulties in diagnosing atypical variants of Alzheimer’s disease

2021 ◽  
Vol 26 (5) ◽  
pp. 16-23
Author(s):  
A. A. Tappakhov ◽  
T. Ya. Nikolaeva ◽  
T. E. Popova ◽  
N. A. Shnayder
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Picture ◽  
Short Term Memory ◽  
Late Onset ◽  
Early Stage ◽  
Primary Progressive Aphasia ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy ◽  
Short Term

Alzheimer’s disease (AD) is the most common cause of dementia in the population. Late onset AD has a classic clinical picture with short-term memory deficit, apraxia and agnosia. Patients with early-onset AD may have an atypical clinical picture which complicates diagnosis. Atypical AD variants include the logopenic variant of primary progressive aphasia, posterior cortical atrophy, behavioral, biparietal, and cortico-basal variants. These variants have pathomorphological signs similar to classical AD, but at an early stage they are characterized by focal atrophy which explains their clinical polymorphism. This article provides a review of the current literature on atypical types of AD and presents a clinical case of a 62-year-old patient in whom the disease debuted with prosopagnosia due to focal atrophy of the temporo-occipital regions of the non-dominant hemisphere.

O4-03-06: Effects of cortical visual impairment on navigational ability in posterior cortical atrophy and typical Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_6) ◽  
pp. P274-P274 ◽  
Author(s):  
Keir X.X. Yong ◽  
Catherine Holloway ◽  
Amelia Carton ◽  
Biao Yang ◽  
Tatsuto Suzuki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Visual Impairment ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy ◽  
Cortical Visual Impairment

scholarly journals Posterior cortical atrophy: A rare variant of Alzheimer’s disease

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Michael A. Meyer ◽  
Stephen A. Hudock
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Photon Emission ◽  
Occipital Cortex ◽  
Cortical Atrophy ◽  
Emission Computed Tomography ◽  
Posterior Cortical Atrophy ◽  
Homonymous Hemianopsia

Posterior cortical atrophy is a rare condition first described in 1988 involving progressive degeneration and atrophy of the occipital cortex, often recognized after an unexplained homonymous hemianopsia may be discovered. We report a case in association with Alzheimer’s disease in a 77-year-old female, who underwent brain single-photon emission computed tomography as well brain positron emission tomography using Florbetapir to further evaluate progressive cognitive decline. The patient had also been followed in Ophthalmology for glaucoma, where a progressive unexplained change in her visual field maps were noted over one year consistent with a progressive right homonymous hemianopsia. This rare combination of findings in association with her dementia led to a detailed review of all her imaging studies, concluding with the surprising recognition for a clear hemi-atrophy of the primary left occipital cortex was occurring, consistent with Alzheimer’s disease affecting the primary visual cortex. Further awareness of this disease pattern is needed, as Alzheimer’s disease typically does not affect the primary visual cortex; other conditions to consider in general include Lewy Body dementia, cortico-basal degeneration and prion disease.

O3-10-01: Object Localisation Deficits in Posterior Cortical Atrophy and Typical Alzheimer's Disease: Tracking Position, Movement and Fixation Patterns within a Simulated Real-World Setting

2016 ◽  
Vol 12 ◽  
pp. P310-P310 ◽  
Author(s):  
Keir Yong ◽  
Amelia M. Carton ◽  
Biao Yang ◽  
Ian McCarthy ◽  
Tatsuto Suzuki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Real World ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy ◽  
Real World Setting

IC-P-191: DIFFUSION TENSOR IMAGING INVESTIGATION OF CORTICAL DISARRAY MEASUREMENT IN POSTERIOR CORTICAL ATROPHY AND TYPICAL ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_2) ◽  
pp. P158-P158
Author(s):  
Mario Torso ◽  
Samrah Ahmed ◽  
Christopher R. Butler ◽  
Mark Jenkinson ◽  
Steven A. Chance
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

scholarly journals Comparison of sub‐tests in working memory index among posterior cortical atrophy, Alzheimer’s disease and age‐associated memory impairment

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Yuthachai Sarutikriangkri ◽  
Anthipa Chokesuwattanaskul ◽  
Kammant Phanthumchinda ◽  
Yuttachai Likitjaroen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Memory Impairment ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

scholarly journals Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer’s disease

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Jurre den Haan ◽  
Lajos Csinscik ◽  
Tom Parker ◽  
Ross W. Paterson ◽  
Catherine F. Slattery ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Retinal Thickness ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy ◽  
Potential Biomarker

P2-029: Similar beta-amyloid burden in posterior cortical atrophy and Alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S317-S317
Author(s):  
Leonardo de Souza ◽  
Fabian Corlier ◽  
Marie Odile Habert ◽  
Olga Uspenskaya ◽  
Renaud Maroy ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Beta Amyloid ◽  
Cortical Atrophy ◽  
Amyloid Burden ◽  
Posterior Cortical Atrophy

scholarly journals Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes

Brain ◽  
2020 ◽  
Vol 143 (7) ◽  
pp. 2281-2294 ◽  
Author(s):  
Irene Sintini ◽  
Jonathan Graff-Radford ◽  
Matthew L Senjem ◽  
Christopher G Schwarz ◽  
Mary M Machulda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Grey Matter ◽  
Clinical Phenotype ◽  
Principal Component ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy ◽  
Longitudinal Patterns ◽  
Progressive Aphasia ◽  
Neuroimaging Biomarkers

Abstract Alzheimer’s disease can present clinically with either the typical amnestic phenotype or with atypical phenotypes, such as logopenic progressive aphasia and posterior cortical atrophy. We have recently described longitudinal patterns of flortaucipir PET uptake and grey matter atrophy in the atypical phenotypes, demonstrating a longitudinal regional disconnect between flortaucipir accumulation and brain atrophy. However, it is unclear how these longitudinal patterns differ from typical Alzheimer’s disease, to what degree flortaucipir and atrophy mirror clinical phenotype in Alzheimer’s disease, and whether optimal longitudinal neuroimaging biomarkers would also differ across phenotypes. We aimed to address these unknowns using a cohort of 57 participants diagnosed with Alzheimer’s disease (18 with typical amnestic Alzheimer’s disease, 17 with posterior cortical atrophy and 22 with logopenic progressive aphasia) that had undergone baseline and 1-year follow-up MRI and flortaucipir PET. Typical Alzheimer’s disease participants were selected to be over 65 years old at baseline scan, while no age criterion was used for atypical Alzheimer’s disease participants. Region and voxel-level rates of tau accumulation and atrophy were assessed relative to 49 cognitively unimpaired individuals and among phenotypes. Principal component analysis was implemented to describe variability in baseline tau uptake and rates of accumulation and baseline grey matter volumes and rates of atrophy across phenotypes. The capability of the principal components to discriminate between phenotypes was assessed with logistic regression. The topography of longitudinal tau accumulation and atrophy differed across phenotypes, with key regions of tau accumulation in the frontal and temporal lobes for all phenotypes and key regions of atrophy in the occipitotemporal regions for posterior cortical atrophy, left temporal lobe for logopenic progressive aphasia and medial and lateral temporal lobe for typical Alzheimer’s disease. Principal component analysis identified patterns of variation in baseline and longitudinal measures of tau uptake and volume that were significantly different across phenotypes. Baseline tau uptake mapped better onto clinical phenotype than longitudinal tau and MRI measures. Our study suggests that optimal longitudinal neuroimaging biomarkers for future clinical treatment trials in Alzheimer’s disease are different for MRI and tau-PET and may differ across phenotypes, particularly for MRI. Baseline tau tracer retention showed the highest fidelity to clinical phenotype, supporting the important causal role of tau as a driver of clinical dysfunction in Alzheimer’s disease.

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