scholarly journals Role of cyclic AMP sensor Epac1 in masseter muscle hypertrophy and myosin heavy chain transition induced by β 2 ‐adrenoceptor stimulation

2014 ◽  
Vol 592 (24) ◽  
pp. 5461-5475 ◽  
Author(s):  
Yoshiki Ohnuki ◽  
Daisuke Umeki ◽  
Yasumasa Mototani ◽  
Huiling Jin ◽  
Wenqian Cai ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Masseter Muscle ◽  
Muscle Hypertrophy

scholarly journals Role of Masseter Muscle β2-Adrenergic Signaling in Regulation of Muscle Activity, Myosin Heavy Chain Transition, and Hypertrophy

2013 ◽  
Vol 123 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Yoshiki Ohnuki ◽  
Daisuke Umeki ◽  
Wenqian Cai ◽  
Nobuhiko Kawai ◽  
Yasumasa Mototani ◽  
...  
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Activity ◽  
Masseter Muscle ◽  
Adrenergic Signaling

scholarly journals Maximum Shortening Velocity and Myosin Heavy-chain Isoform Expression in Human Masseter Muscle Fibers

2001 ◽  
Vol 80 (9) ◽  
pp. 1845-1848 ◽  
Author(s):  
T.J. Morris ◽  
C.A. Branden ◽  
M.J. Horton ◽  
D.S. Carlson ◽  
J.J. Sciote
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Masseter Muscle ◽  
Muscle Fibers ◽  
Shortening Velocity ◽  
Myosin Heavy Chain Isoform ◽  
Isoform Expression

scholarly journals Immunochemical Probing of the Functional Role of the 238-246 and 567-574 Sequences of Myosin Heavy Chain

1995 ◽  
Vol 232 (1) ◽  
pp. 235-240 ◽  
Author(s):  
Edna Blotnick ◽  
Carl Miller ◽  
Ute Groschel-Stewart ◽  
Andras Muhlrad
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Functional Role

scholarly journals Calcineurin plays a modulatory role in loading-induced regulation of type I myosin heavy chain gene expression in slow skeletal muscle

2009 ◽  
Vol 297 (4) ◽  
pp. R1037-R1048 ◽  
Author(s):  
Clay E. Pandorf ◽  
Weihua H. Jiang ◽  
Anqi X. Qin ◽  
Paul W. Bodell ◽  
Kenneth M. Baldwin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Fiber Type ◽  
Hindlimb Suspension ◽  
Chain Gene ◽  
Type I ◽  
Thyroid State

The role of calcineurin (Cn) in skeletal muscle fiber-type expression has been a subject of great interest because of reports indicating that it controls the slow muscle phenotype. To delineate the role of Cn in phenotype remodeling, particularly its role in driving expression of the type I myosin heavy chain (MHC) gene, we used a novel strategy whereby a profound transition from fast to slow fiber type is induced and examined in the absence and presence of cyclosporin A (CsA), a Cn inhibitor. To induce the fast-to-slow transition, we first subjected rats to 7 days of hindlimb suspension (HS) + thyroid hormone [triiodothyronine (T3)] to suppress nearly all expression of type I MHC mRNA in the soleus muscle. HS + T3 was then withdrawn, and rats resumed normal ambulation and thyroid state, during which vehicle or CsA (30 mg·kg−1·day−1) was administered for 7 or 14 days. The findings demonstrate that, despite significant inhibition of Cn, pre-mRNA, mRNA, and protein abundance of type I MHC increased markedly during reloading relative to HS + T3 ( P < 0.05). Type I MHC expression was, however, attenuated by CsA compared with vehicle treatment. In addition, type IIa and IIx MHC pre-mRNA, mRNA, and relative protein levels were increased in Cn-treated compared with vehicle-treated rats. These findings indicate that Cn has a modulatory role in MHC transcription, rather than a role as a primary regulator of slow MHC gene expression.

scholarly journals Effects of Chronic Akt/mTOR Inhibition by Rapamycin on Mechanical Overload–Induced Hypertrophy and Myosin Heavy Chain Transition in Masseter Muscle

2013 ◽  
Vol 122 (4) ◽  
pp. 278-288 ◽  
Author(s):  
Daisuke Umeki ◽  
Yoshiki Ohnuki ◽  
Yasumasa Mototani ◽  
Kouichi Shiozawa ◽  
Takayuki Fujita ◽  
...  
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Masseter Muscle ◽  
Mtor Inhibition ◽  
Mechanical Overload

scholarly journals Fetal myosin heavy chain increases in the human masseter muscle during aging

FEBS Letters ◽  
1996 ◽  
Vol 386 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Mehrdad Monemi ◽  
Per-Olof Eriksson ◽  
Ihari Dubail ◽  
Gillian S. Butler-Browne ◽  
Lars-Erik Thornell
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Masseter Muscle
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