scholarly journals A Curved Port Delivery System for Laser Interstitial Thermal Therapy of Brain Tumors

2019 ◽  
Author(s):  
Nnaoma Agwu ◽  
Kyle Deprow ◽  
John E. Williams ◽  
Jenna L. Gorlewicz ◽  
Eric C. Leuthardt
Keyword(s):  
Heat Treatment ◽  
Brain Tumors ◽  
Delivery System ◽  
Thermal Therapy ◽  
Neurosurgical Procedure ◽  
Surgical Tools ◽  
Laser Interstitial Thermal Therapy ◽  
Steerable Needles ◽  
The Brain ◽  
Straight Trajectory

Laser interstitial thermal therapy (LITT) is a neurosurgical procedure that involves using heat treatment to ablate glioblastomas in the brain. Current methods for placing probes in LITT involve straight trajectory pathways. This limitation often requires surgeons to make multiple trajectories or leave undesired margins. There has been extensive work in steerable needles, concentric tube cannulas, and flexible surgical tools. In this work, we present an approach which focuses on providing steerability to tools that aren’t inherently steerable. To do this, we developed a curved port delivery system that leverages an active cannula for the deployment of a plastic, flexible port that delivers existing surgical tools. We present an initial prototype coupled with feasibility results illustrating that the port can be placed to steer probes to a desired location.

scholarly journals MR-Guided Laser Interstitial Thermal Therapy for Treatment of Brain Tumors

2020 ◽  
Author(s):  
Alexa Semonche ◽  
Evan Luther ◽  
Katherine Berry ◽  
Ashish Shah ◽  
Daniel Eichberg ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy

scholarly journals NT-30 * COMPLICATIONS OF LASER INTERSTITIAL THERMAL THERAPY IN PATIENTS WITH BRAIN TUMORS

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v165-v165
Author(s):  
M. Schulder ◽  
K. Black ◽  
A. Mehta ◽  
A. Gamble
Keyword(s):  
Brain Tumors ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy

Laser interstitial thermal therapy as a novel treatment modality for brain tumors in the thalamus and basal ganglia

2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Jason L. Schroeder ◽  
Symeon Missios ◽  
Gene H. Barnett ◽  
Alireza Mohammad Mohammadi
Keyword(s):  
Surgical Treatment ◽  
Basal Ganglia ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Minimally Invasive ◽  
Thermal Therapy ◽  
Neurological Deficits ◽  
Tumor Cell Death ◽  
Primary Tumors ◽  
Laser Interstitial Thermal Therapy

AbstractIntroduction:Deep-seated hemispheric brain tumors pose unique challenges for surgical treatment. These tumors are often considered inoperable and when surgery is undertaken significant, serious, morbidity and even mortality may complicate the outcome. Laser interstitial thermal therapy (LITT) is a minimally invasive alternative to traditional open surgery that affects tumor cell death by producing a zone of thermal tissue damage that can be monitored and controlled with the aid of real-time magnetic resonance thermography.Subjects and methods:A retrospective review of six patients treated with LITT at the Cleveland Clinic between 5/2011 and 8/2013 was performed. We evaluated clinical patient data and pre-, intra-, and post-operative magnetic resonance imaging (MRI) data for correlation.Results:Six patients were treated with a total of eight separate LITT procedures for their thalamic (n=5) or basal ganglia (n=1) tumors. All tumors were histologically malignant and five were primary tumors. Pre- and post-operative neurological deficits were recorded. The two patients that underwent multiple procedures were retreated for different reasons – one due to insufficient coverage and the other due to tumor recurrence. Sustained post-operative neurological deficits were observed after three procedures and one patient died within 2 days of surgery from a thalamic hemorrhage.Conclusions:LITT is a minimally invasive surgical treatment that can lead to successful ablation of tumors of the thalamus or basal ganglia. However, this treatment has the potential for neurological morbidity or even mortality and as such further studies are needed to evaluate the true risk vs. reward potential for LITT with regard to treating deep-seated tumors.

Laser Interstitial Thermal Therapy in the Treatment of Thalamic Brain Tumors: A Case Series

2020 ◽  
Author(s):  
Roger Murayi ◽  
Hamid Borghei-Razavi ◽  
Gene H Barnett ◽  
Alireza M Mohammadi
Keyword(s):  
Brain Tumors ◽  
Thermal Damage ◽  
Case Series ◽  
Outcome Data ◽  
Thermal Therapy ◽  
Treatment Modalities ◽  
Intracerebral Hematoma ◽  
Average Hospital ◽  
Laser Interstitial Thermal Therapy ◽  
Thalamic Tumors

Abstract BACKGROUND Surgical options for patients with thalamic brain tumors are limited. Traditional surgical resection is associated with a high degree of morbidity and mortality. Laser interstitial thermal therapy (LITT) utilizes a stereotactically placed laser probe to induce thermal damage to tumor tissue. LITT provides a surgical cytoreduction option for this challenging patient population. We present our experience treating thalamic brain tumors with LITT. OBJECTIVE To describe our experience and outcomes using LITT on patients with thalamic tumors. METHODS We analyzed 13 consecutive patients treated with LITT for thalamic tumors from 2012 to 2017. Radiographic, clinical characteristics, and outcome data were collected via review of electronic medical records RESULTS Thirteen patients with thalamic tumors were treated with LITT. Most had high-grade gliomas, including glioblastoma (n = 9) and anaplastic astrocytoma (n = 2). The average tumor volume was 12.0 cc and shrank by 42.9% at 3 mo. The average hospital stay was 3.0 d. Median ablation coverage as calculated by thermal damage threshold (TDT) lines was 98% and 95% for yellow (>43°C for >2 min) or blue (>10 min), respectively. Median disease-specific progression-free survival calculated for 8 patients in our cohort was 6.1 mo (range: 1.1-15.1 mo). There were 6 patients with perioperative morbidity and 2 perioperative deaths because of intracerebral hematoma. CONCLUSION LITT is a feasible treatment for patients with thalamic tumors. LITT offers a cytoreduction option in this challenging population. Patient selection is key. Close attention should be paid to lesion size to minimize morbidity. More studies comparing treatment modalities of thalamic tumors need to be performed.

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