Fundamental Investigations of Driving Force of a Neutrophile in Liquid Using Concentration Marangoni Effect for Developing Microcapsules in Drug Delivery Systems

2008 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Drug Delivery ◽  
Concentration Gradient ◽  
Driving Force ◽  
Drug Delivery Systems ◽  
Marangoni Effect ◽  
Delivery Systems ◽  
Cytokine Concentration

This paper describes the effects of gradient of cytokine concentration on chemotaxis of neutrophile by observing the motion in liquid with adding cytokine concentration. The aim of this investigation is to control of neutrophile motion in liquid by concentration gradient for drug delivery systems.

Fundamental Investigations of Driving Force of Microcapsule for Drug Delivery Systems Using the Principle of Neutrophile’s Chemotaxis

2007 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cytokine Concentration ◽  
Marangoni Effects

This paper describes the effects of gradient of cytokine concentration on chemotaxis of neutrophile by observing the motion in liquid with adding cytokine concentration. The aim of this investigation is to distinguish the driving force by Marangoni effects from amebic motion.

Analysis of a Bubble Deformation Process in a Microcapsule for Developing Drug Delivery Systems Using Underwater Shock Waves

2010 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Shock Wave ◽  
Drug Delivery ◽  
Shock Waves ◽  
Transport Process ◽  
Deformation Process ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cytokine Concentration ◽  
Bubble Deformation ◽  
Underwater Shock

This paper describes development of microcapsule using underwater shock waves, especially (1) the trial of making smaller microcapsules including a bubble for shock wave drug delivery systems, and analysis of a bubble deformation process to have higher efficiency of disintegration by shock wave, and (2) the effects of gradient of cytokine concentration on neutrophile motion in liquid by observing the concentration transport process with adding cytokine for developing drug delivery systems.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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