Simulation of Red Blood Cell Deformation in Microvessels Using a New Rapid Modified Particle Method

2011 ◽  
Author(s):  
K. Firoozbakhsh ◽  
M. T. Ahmadian ◽  
M. Hasanian ◽  
S. Samiezadeh
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Complex Geometry ◽  
Fluid Pressure ◽  
Real Life ◽  
Particle Method ◽  
Original Method ◽  
Discrete Models ◽  
Mps Method ◽  
Long Time

The deformation of human red blood cell has been a topic of considerable scientific interest and real-life significance. Several methods have been improved to simulate the behavior of red blood cells motion and deformation in micro-capillaries. Since in microscopic scales, using discrete models are more preferred than continuum methods, moving particle semi-implicit method (MPS) which is one of the recent innovative particle based methods, can simulate micro-fluidic flows based on Navier-Stocks equations. It has been shown that original MPS method has a lack of rapid calculation which leads to massive calculations and long time simulation. Quite a few studies have been done to improve MPS method. But the main problem, calculation of viscosity effect in conjunction with fluid pressure distribution, is still under discussion. In this paper a new algorithm is proposed that is to say by this method simulation duration decreases by the factor of 20 while the accuracy of the results remains constant. The results indicate that while the velocity precision is as well as original method, the duration of simulation is reduced more than 20 times. This significant novel MPS algorithm can be implemented in future studies for simulation of multi-fluid flows, complex geometry flows and micro-scale biomedical phenomena.

7. Epilogue: the future of blood

2016 ◽  
pp. 124-130
Author(s):  
Chris Cooper
Keyword(s):  
Stem Cell ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Blood Substitute ◽  
Liquid Form ◽  
Blood Typing ◽  
Cell Technology ◽  
Long Time ◽  
Red Blood Cell Transfusions

For a long time, synthetic biologists have attempted to manufacture an artificial, easily stored and transported, blood substitute that does not require blood typing, is long lasting, and can be guaranteed pathogen free. Three different methods have been attempted to replace red blood cell transfusions: the use of perfluorocarbons, inert chemicals that, in liquid form, can dissolve gases without reacting with them; creating a haemoglobin-based blood substitute—but despite almost a billion dollars of research and development there is not one in general use today; and growing artificial red blood cells using stem cell technology—but doing this safely, reproducibly, and in large amounts is a huge bioengineering challenge.

scholarly journals IV. On the structure of the red blood-corpuscle of oviparous vertebrata

1869 ◽  
Vol 17 ◽  
pp. 346-350
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
The Other ◽  
Red Cell ◽  
Blood Corpuscle ◽  
Fundamental Distinction ◽  
Long Time ◽  
History Of

The red blood-cell has been perhaps more frequently and fully examined than any other animal structure; certainly none has evoked such various and even contradictory opinions of its nature. But without attempting here any history of these, it may be shortly said that amongst the conclusions now, and for a long time past, generally accepted, a chief one is that a fundamental distinction exists between the red corpuscle of Mammalia and that of the other vertebrate classes—that the red cell of the oviparous vertebrata possesses a nucleus which is not to be found in the corpuscle of the other class. This great distinction between the classes has of late years been over and over again laid down in the strongest and most unqualified terms. But I venture to ask for a still further examination of this important subject.

scholarly journals Investigation of red blood cell mechanical properties using AFM indentation and coarse-grained particle method

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Sarah Barns ◽  
Marie Anne Balanant ◽  
Emilie Sauret ◽  
Robert Flower ◽  
Suvash Saha ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Particle Method ◽  
Coarse Grained ◽  
Afm Indentation ◽  
Cell Mechanical Properties

Two-Dimensional Vessel-Motion/Liquid-Sloshing Interactions and Impact Loads by Using a Particle Method

2010 ◽  
Author(s):  
B.-H. Lee ◽  
J.-C. Park ◽  
M.-H. Kim
Keyword(s):  
Free Surface ◽  
Flow Simulation ◽  
Particle Method ◽  
Original Method ◽  
Floating Body ◽  
Impact Loads ◽  
Robust Algorithms ◽  
Mps Method ◽  
Highly Nonlinear ◽  
Vessel Motion

The violent free-surface motions interacting with floating vessels containing inner liquid tanks are investigated by using the newly developed Moving Particle Semi-implicit (MPS) method for 2-dimensional incompressible flow simulation. In the present numerical examples, many efficient and robust algorithms have been developed to improve the overall quality and efficiency in solving various highly nonlinear free-surface problems and evaluating impact pressures compared to the original method proposed by Koshizuka and Oka (1996). For illustration, the improved MPS method is applied to the simulation of nonlinear floating-body motions, violent sloshing motions and corresponding impact loads, and vessel motions with inner liquid tanks. It is seen that the roll amplitudes can be significantly reduced due to the presence of the sloshing tank when the excitation frequencies are away from the lowest sloshing natural frequencies. The developed numerical tools can be used to the study of vessel motions with liquid cargo or design of passive anti-rolling devices.

scholarly journals 506 Red blood cell flow simulation using MPS method

2008 ◽  
Vol 2008.45 (0) ◽  
pp. 151-152
Author(s):  
Atsushi YOSHIDA ◽  
Teruo MATSUZAWA
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Flow Simulation ◽  
Mps Method

Development of the Inflow Boundary With a Free Surface to Apply the MPS Method to Tsunami Analysis on Coastal Areas

2012 ◽  
Author(s):  
Koichi Masuda ◽  
Tomoki Ikoma ◽  
Yasuhiro Aida ◽  
Junpei Takayama
Keyword(s):  
Free Surface ◽  
Fluid Velocity ◽  
Fluid Pressure ◽  
Particle Method ◽  
Wave Form ◽  
Mps Method ◽  
Wave Elevation ◽  
Wave Maker ◽  
Computationally Expensive ◽  
Run Up

The wave maker of MPS method, a kind of particle method, with free surface is developed in this study. This wave maker has the function of the inflow and outflow of particles. Compared to piston-type wave maker, this is possible to reduce the particle for calculation keeping wave form. As a result, this way is faster computation than that. This way controlled by fluid velocity and wave elevation is able to input propagating tsunami of actual phenomenon and data generated by the other result of MPS method and able to continue simulation. This means that it is possible to simulate in detail with 3D-MPS method after 2D-MPS method that is less computationally expensive. This approach is applied to the analysis to tsunami in coastal area. In this study, fluid pressure of run-up-tsunami affecting a building with MPS method is compared and with experiment. And applying MPS method to analysis of run-up-tsunami is considered.

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