Modeling DNA Translocation Kinetics in Nanopores With Selectivity

2010 ◽  
Author(s):  
Abhijit Ramachandran ◽  
Qingjiang Guo ◽  
Samir Iqbal ◽  
Yaling Liu
Keyword(s):  
Solid State ◽  
Gene Sequencing ◽  
Biological Molecules ◽  
Dna Translocation ◽  
Molecular Sensing

The development in nanotechnology has made fabrication of solid-state nanopores with 20nm diameter possible. These nanopores have found a variety of applications, with the foremost one being sensing of the biological molecules. To achieve molecular sensing, a major requirement of these solid state nanopores is molecular selectivity. This paper focuses on modeling the DNA translocation in functionalized nanopore with application on gene sequencing.

scholarly journals Controlling DNA Translocation Through Solid-state Nanopores

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Zhishan Yuan ◽  
Youming Liu ◽  
Min Dai ◽  
Xin Yi ◽  
Chengyong Wang
Keyword(s):  
Solid State ◽  
Dna Translocation

scholarly journals Nanopore design for exceptional rectification of DNA translocation

2021 ◽  
Author(s):  
Ngan Pham ◽  
Yao Yao ◽  
Chenyu Wen ◽  
Shiyu Li ◽  
Shuangshuang Zeng ◽  
...  
Keyword(s):  
Numerical Simulation ◽  
Solid State ◽  
Surface Charge ◽  
Dna Translocation ◽  
Sensor Applications ◽  
Sensor Performance ◽  
On Demand ◽  
Dna Strands ◽  
Large Opening ◽  
Shape And Size

Abstract Solid-state nanopores (SSNPs) of on-demand shape and size can facilitate desired sensor performance. However, reproducible production of arrayed nanopores of predefined geometry is yet to demonstrate despite of numerous methods explored. Here, bowl-shape SSNPs combining unique properties of ultrathin membrane and tapering geometry are demonstrated. The bowl-SSNP upper opening is 100-120 nm in diameter, with the bottom opening reaching sub-5 nm. Numerical simulation reveals the formation of multiple electroosmotic vortexes (EOVs) originating from distributed surface charge around the pore-bowl. The EOVs determine, collaboratively with electrophoretic force, how nanoscale objects translocate the bowl-SSNPs. Exceptional rectification with higher frequencies, longer duration and larger amplitude is found when DNA strands translocate downwards from the upper large opening than upwards from the bottom smallest restriction. The rectification is a manifestation of the interplay between electrophoresis and electroosmosis. The resourceful silicon nanofabrication technology is ingeniously shown to enable innovative nanopore designs targeting unprecedented sensor applications.

scholarly journals 1P513 Solid-State ^O NMR of Biological Molecules(25. New methods and tools (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

2006 ◽  
Vol 46 (supplement2) ◽  
pp. S275
Author(s):  
Kazuhiko Yamada ◽  
Miwako Asanuma ◽  
Toshio Yamazaki ◽  
Hiroshi Hirota
Keyword(s):  
Solid State ◽  
Poster Session ◽  
Biological Molecules ◽  
New Methods ◽  
Meeting Program

scholarly journals Immobilization of Bioengineered Portal Protein Within a Solid-State Nanopore for Molecular Sensing

2020 ◽  
Vol 118 (3) ◽  
pp. 156a
Author(s):  
Mehrnaz Mojtabavi ◽  
Sandra Greive ◽  
Alfred Antson ◽  
Meni Wanunu
Keyword(s):  
Solid State ◽  
Molecular Sensing ◽  
Portal Protein

Enhancing the sensitivity of DNA detection by structurally modified solid-state nanopore

Nanoscale ◽  
2017 ◽  
Vol 9 (45) ◽  
pp. 18012-18021 ◽  
Author(s):  
Kidan Lee ◽  
Hyomin Lee ◽  
Seung-Hyun Lee ◽  
Hyun-Mi Kim ◽  
Ki-Bum Kim ◽  
...  
Keyword(s):  
Solid State ◽  
Dwell Time ◽  
Dna Detection ◽  
Dna Translocation

Guide nanostructures fabricated in front of conventional nanopore device would significantly increase both SNR and dwell time of DNA translocation.

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