Three-Dimensional Finite Element Analysis of Intervertebral Disc: Effects of In Vivo Loading Conditions and Endplate Calcification on Glucose Distributions

Author(s):  
Alicia R. Jackson ◽  
Chun-Yuh Huang ◽  
Wei Yong Gu

Degeneration of the intervertebral disc (IVD) of the spine is a common condition which has been implicated as a factor leading to low back pain. Poor nutritional supply is believed to be a primary contributor to IVD degeneration. Because the disc is the largest avascular structure in the body, cells must rely on transport of important nutrients, such as glucose and oxygen, from the surrounding vasculature in order to maintain cell viability in the disc tissue. Due to difficulty in obtaining data in vivo, theoretical modeling is a useful tool to supplement experimental results and predict in vivo conditions.

2020 ◽  
Author(s):  
Kai Guo ◽  
Jiawei Lu ◽  
Ziqi Zhu ◽  
Beiduo Shen ◽  
Tongde Wu ◽  
...  

Abstract Background: ACDF is the main treatment of cervical disease. Adjacent Segment Degeneration (ASD) is the main complication of long-term follow-up of ACDF. we conduct a detailed study of ACDF by means of three-dimensional finite element analysis and find the effect of screw placement and location on the occurrence of ASD.Methods: The cervical computed tomography (CT) data (layer thickness of 0.625 mm) for a 30-year-old healthy male volunteer was collected. All the data were combined to create a C2-7 3D finite element model using Abaqus software. Based on the data and the actual surgical maneuver, a screw positioning model was established, in order to observe the cervical range of motion (ROM) with different positions of screw, as well as the pressure change of the adjacent segment intervertebral disc.Results: The proposed finite element model of cervical spine was effective, and ROM on all directions of C4-C6 segments changed after ACDF surgery. Under the same torque settings, compared with the control group, C2/3 segment rotational ROM increased; C2/3, C3/4 segments lateral flexion ROM also increased. Regarding the influence of screw positioning, it has limited influence on the ROM and The intervertebral disc pressure (IDP), and compared with different horizontal positions, different vertical positions imposed greater influence on the ROM and IDP. Conclusions: For ACDF surgery, positioning the screw at the anterior inferior part of the cervical vertebral body could provide more natural cervical ROM and the least IDP, while maintaining high biomechanical stability, and is more in line with human biomechanical requirements.


1993 ◽  
Vol 42 (3) ◽  
pp. 1087-1091
Author(s):  
Koji Totoribe ◽  
Naoya Tajima ◽  
Shigeru Kuwahara ◽  
Shunichi Hirakawa ◽  
Kouichi Matsumoto ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Huaili Ding ◽  
Lijun Liao ◽  
Peichun Yan ◽  
Xiaolin Zhao ◽  
Min Li

Objective. To study and analyze the changes of intervertebral foramen height and area of the degenerative L4-5 intervertebral disc under different pushing heights by the finite element method. Methods. CT and MRI images of T12-S1 segments were obtained from a healthy volunteer who met the inclusion criteria. A DR machine was used to capture images of the lumbar lateral section before and after simultaneous pushing of the L4 and L5 spinous processes by manipulation called Daogaijinbei, and the measurement showed that the displacement changes of L4 and L5 were both approximately 10 cm, so the pushing height was set at 0–10 cm. A three-dimensional finite element model of the entire normal lumbar spine was established using Mimics 16.0, Geomagic Studio 2014, Hypermesh 13.0, MSC.Patran 2012, and so on. The disc height and nucleus area of the lumbar disc of the normal entire lumbar disc model were adjusted to establish models of the L4-5 disc with mild, moderate, and severe degeneration. Changes of disc height and area of the L4-5 degenerative intervertebral disc under different pushing heights were calculated. Results. The size of the L4-5 intervertebral foramen was analyzed from the height and area of the intervertebral foramen, and the results showed the following: (1) as for the normal lumbar disc and a lumbar of the L4-5 disc with mild and moderate degeneration, the height of the L4-5 intervertebral foramen and its area both increased during pushing between 0 and 8 cm. After the pushing height reached 8 cm, the height and area of the L4-5 intervertebral foramen gradually became stable; (2) as for the L4-5 disc with severe degeneration, during the process of pushing, the height and area of the L4-5 intervertebral foramen increased slightly, but this change was not obvious. Conclusions. After the spinal manipulation, the sizes of the L4-5 intervertebral foramen of the L4-5 disc with mild and moderate degeneration were significantly larger than those before pushing; in contrast, the size of L4-5 intervertebral foramen of the L4-5 disc with severe lumbar degeneration was not significantly changed.


2007 ◽  
Vol 35 (3) ◽  
pp. 226-238 ◽  
Author(s):  
K. M. Jeong ◽  
K. W. Kim ◽  
H. G. Beom ◽  
J. U. Park

Abstract The effects of variations in stiffness and geometry on the nonuniformity of tires are investigated by using the finite element analysis. In order to evaluate tire uniformity, a three-dimensional finite element model of the tire with imperfections is developed. This paper considers how imperfections, such as variations in stiffness or geometry and run-out, contribute to detrimental effects on tire nonuniformity. It is found that the radial force variation of a tire with imperfections depends strongly on the geometrical variations of the tire.


Sign in / Sign up

Export Citation Format

Share Document