Development of Methodology to Assess the Effect of Stem Surface Finish on Implant Loosening

Joint replacement surgery is a common orthopaedic procedure used for the treatment of diseased or damaged joints. The majority of these replacement systems incorporate a stemmed portion which is inserted into the bone canal, either with or without bone cement, to achieve fixation to the host bone. Although this procedure has proven effective, relative displacement at the bone-cement and/or cement-stem interfaces (i.e., implant loosening) is a common complication, leading to pain and the need for revision surgery.

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The Effect of Intramedullary Stem Curvature on the Torsional Stability of Cemented Joint Replacement Systems

ASME 2011 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2011-53530 ◽

2011 ◽

Author(s):

Yara K. Hosein ◽

Meghan P. Clynick ◽

Sarah E. Takaki ◽

Stewart D. McLachlin ◽

Cynthia E. Dunning

Keyword(s):

Bone Cement ◽

Joint Replacement ◽

Revision Surgery ◽

Host Bone ◽

Common Complication ◽

Implant Loosening ◽

Torsional Stability ◽

Stem Curvature

Joint replacement surgeries are a common treatment for diseased or damaged joints. The procedure typically involves the insertion of a metal stemmed component into the bone canal, either with or without bone cement, to achieve fixation to the host bone. Although this procedure has proven effective, implant loosening remains a relatively common complication, leading to pain and the eventual need for revision surgery.

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Development of operator independent bone cement vacuum mixing system for joint replacement surgery

Plastics Rubber and Composites ◽

10.1179/174328906x143822 ◽

2006 ◽

Vol 35 (8) ◽

pp. 317-323 ◽

Cited By ~ 3

Author(s):

N. Dunne ◽

Y. Xu ◽

C. Daly ◽

J. Makem ◽

G. Walker ◽

...

Keyword(s):

Bone Cement ◽

Joint Replacement ◽

Joint Replacement Surgery ◽

Replacement Surgery ◽

Vacuum Mixing

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Age at hip or knee joint replacement surgery predicts likelihood of revision surgery

Journal of Bone and Joint Surgery - British Volume ◽

10.1302/0301-620x.93b10.27100 ◽

2011 ◽

Vol 93-B (10) ◽

pp. 1411-1415 ◽

Cited By ~ 41

Author(s):

C. Wainwright ◽

J.-C. Theis ◽

N. Garneti ◽

M. Melloh

Keyword(s):

Knee Joint ◽

Joint Replacement ◽

Revision Surgery ◽

Knee Joint Replacement ◽

Joint Replacement Surgery ◽

Replacement Surgery

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Influence of Antibiotic-Loaded Acrylic Bone Cement Composition on Drug Release Behavior and Mechanism

Polymers ◽

10.3390/polym13142240 ◽

2021 ◽

Vol 13 (14) ◽

pp. 2240

Author(s):

I-Cheng Chen ◽

Chen-Ying Su ◽

Wei-Han Nien ◽

Tzu-Tien Huang ◽

Chang-Hung Huang ◽

...

Keyword(s):

Infection Control ◽

Bone Cement ◽

Joint Replacement ◽

Total Joint Replacement ◽

Joint Infection ◽

Acrylic Bone Cement ◽

Joint Replacement Surgery ◽

Replacement Surgery ◽

Antibiotic Release

Periprosthetic joint infection (PJI) is a devastating complication after total joint replacement with considerable morbidity and large economic burdens. Antibiotic-Loaded Bone Cement (ALBC) has been developed as a valuable tool for local administration and is becoming one of the most effective methods for the prevention and treatment of orthopedic infections. Controlling antibiotic release from ALBC is critical to achieve effective infection control, however, the antibiotic elution rates are generally low, and the mechanisms are poorly understood. Thus, the present study aims to investigate the effects of the basic acrylic bone cement components, including liquid/powder (monomer-to-polymer) ratios, radiopacifier, initiator, and doses of antibiotics on the porosity, antibiotic elution rates and mechanical properties of polymethylmethacrylate (PMMA) based ALBC. The obtained results from the in vitro studies suggested that a reduction in the liquid/powder ratio and an increase in the radiopacifier ratio and gentamicin doses led to increased porosity and release of antibiotic, while the initiator ratio exerted no effect on elution rates. In conclusion, we hope that by varying the composition of ALBC, we could considerably enhance the antibiotic elution rates by increasing porosity, while maintaining an adequate mechanical strength of the bone cements. This finding might provide insights into controlling antibiotic release from ALBC to achieve effective infection control after total joint replacement surgery.

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