scholarly journals Near-infrared angiography for critical limb ischemia in a diabetic murine model

2017 ◽  
Vol 22 (04) ◽  
pp. 1 ◽  
Author(s):  
Missael Garcia ◽  
Mohamed A. Zayed ◽  
Kyoung-mi Park ◽  
Viktor Gruev
Keyword(s):  
Murine Model ◽  
Critical Limb Ischemia ◽  
Near Infrared ◽  
Limb Ischemia

scholarly journals N-acetylcysteine effects on a murine model of chronic critical limb ischemia

2018 ◽  
Vol 1864 (2) ◽  
pp. 454-463 ◽  
Author(s):  
Wallace Aguiar de Medeiros ◽  
Leandro Almeida da Silva ◽  
Dhébora Mozena Dall'Igna ◽  
Monique Michels ◽  
Andressa Manfredini ◽  
...  
Keyword(s):  
Murine Model ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Chronic Critical Limb Ischemia

scholarly journals Near-infrared fluorescence imaging with indocyanine green in diabetic patient with critical limb ischemia: a case report

2018 ◽  
Vol 21 (4) ◽  
pp. 319-324
Author(s):  
Zera N. Dzhemilova ◽  
Ivan I. Sitkin ◽  
Svetlana V. Sergeeva ◽  
Pavel V. Grachev ◽  
Kirill G. Linkov ◽  
...  
Keyword(s):  
Case Report ◽  
Indocyanine Green ◽  
Critical Limb Ischemia ◽  
Lower Limb ◽  
Near Infrared ◽  
Limb Ischemia ◽  
Regions Of Interest ◽  
Infrared Range ◽  
Lower Limb Ischemia ◽  
Near Infrared Range

A case report of type 2 diabetic patient with critical limb ischemia (CLI) after successful endovascular revascularization is reported. The diagnosis of CLI was established according to clinical data and results of lower limb ischemia assessment by non-invasive methods. The unique feature of this case is presentation of results of the new method of lower limb ischemia assessment fluorescent angiography in near infrared range using indocyanine green (ICG). Following parameters of fluorescent angiography in near infrared range are analyzed in different regions of interest: Tstart(sec) the time of fluorescence occurrence (Istart, unit) in the analyzed area after intravenous administration of ICG; Tmax (sec) time to achieve maximum fluorescence (Imax, unit) after intravenous injection of ICG; Tmax Tstart (sec) the time difference between Imax and Istart. In this clinical case, the time of achievement Istart, Imax, Tmax Tstart in different regions of interest decreased after successful endovascular revascularization of lower limb arteries.

The significance of regional hemoglobin oxygen saturation values and limb-to-arm ratios of near-infrared spectroscopy to detect critical limb ischemia

Vascular ◽  
2016 ◽  
Vol 24 (5) ◽  
pp. 492-500 ◽  
Author(s):  
Reinout PE Boezeman ◽  
Doeke Boersma ◽  
Jan Wille ◽  
Johannes C Kelder ◽  
Mareije I Visscher ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Oxygen Saturation ◽  
Near Infrared Spectroscopy ◽  
Critical Limb Ischemia ◽  
Lower Limb ◽  
Predictive Value ◽  
Near Infrared ◽  
Limb Ischemia ◽  
Added Value ◽  
Hemoglobin Oxygen Saturation

This study examines the application of near-infrared spectroscopy to noninvasively detect critical limb ischemia using regional hemoglobin oxygen saturation in percentage values and regional hemoglobin oxygen saturation limb-to-arm ratios. The regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios were calculated in 61 patients with critical limb ischemia (group A). Measurements were performed in rest at four fixed spots at the most affected lower limb and at a reference spot at both upper arms. Similar measurements were performed in the left lower limb of 30 age-matched control patients without peripheral arterial disease (group B). The regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios were significantly different at all measured spots between the groups (all p < 0.001), except for the regional hemoglobin oxygen saturation limb-to-arm ratios of the distal vastus lateralis ( p = 0.056). However, a broad overlap of individual regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios was found in both groups, which resulted in poor discriminative predictive value of single measurements. Single measurements of regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios at all measured spots have poor discriminative predictive value in detection of critical limb ischemia. Measurement of regional hemoglobin oxygen saturation values and regional hemoglobin oxygen saturation limb-to-arm ratios at any of the measurement spots has no added value in detecting lower limb ischemia in individuals compared with current diagnostic modalities.

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