Tacky COC: a solvent bonding technique for fabrication of microfluidic systems

2016 ◽  
Author(s):  
Nico Keller ◽  
Tobias M. Nargang ◽  
Dorothea Helmer ◽  
Bastian E. Rapp
Keyword(s):  
Microfluidic Systems ◽  
Solvent Bonding ◽  
Bonding Technique

Solvents for irreversible sealing of microfluidic polymethylmethacrylate devices by solvent bonding technique

2020 ◽  
Vol 0 (12) ◽  
pp. 27-33
Author(s):  
T. A. Lukashenko ◽  
◽  
A. N. Zubik ◽  
A. L. Bulyanitsa ◽  
A. I. Tsimbalov ◽  
...  
Keyword(s):  
Adhesive Bonding ◽  
Qualitative And Quantitative ◽  
Working Volume ◽  
Solvent Bonding ◽  
Bonding Technique

The solvents to be compatible with polymethylmethacrylate (PMMA) were selected on the basis of qualitative and quantitative criteria. The features of the solvent bonding connecting seam of the irreversible bonding PMMA of various trademarks have been studied. It is shown that the method of solvent bonding with vinylacetate can be an alternative to adhesive bonding when sealing microchips since the solvent bonding connecting seam makes a smaller contribution to the change in the working volume of microstructures.

A Fluidic Motherboard for Multiplexed Simultaneous and Modular Detection in Microfluidic Systems for Biological Application

2010 ◽  
Vol 2 (4) ◽  
pp. 227-238 ◽  
Author(s):  
Gerardo Perozziello ◽  
Giuseppina Simone ◽  
Patrizio Candeloro ◽  
Francesco Gentile ◽  
Natalia Malara ◽  
...  
Keyword(s):  
Biological Application ◽  
Microfluidic Systems

Cell Culture in Microfluidic Systems

2013 ◽  
Vol 5 (2) ◽  
pp. 82-96 ◽  
Author(s):  
Yung-Shin Sun ◽  
Ji-Yen Cheng
Keyword(s):  
Cell Culture ◽  
Microfluidic Systems

Cell Washing and Solution Exchange in Droplet Microfluidic Systems

2021 ◽  
Author(s):  
Can Huang ◽  
Han Zhang ◽  
Song-I Han ◽  
Arum Han
Keyword(s):  
Microfluidic Systems ◽  
Solution Exchange

scholarly journals High-performance half-Heusler thermoelectric devices through direct bonding technique

2021 ◽  
Vol 493 ◽  
pp. 229695
Author(s):  
Amin Nozariasbmarz ◽  
Udara Saparamadu ◽  
Wenjie Li ◽  
Han Byul Kang ◽  
Carter Dettor ◽  
...  
Keyword(s):  
High Performance ◽  
Thermoelectric Devices ◽  
Bonding Technique

Goodbye fouling: A unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Peer Erfle ◽  
Juliane Riewe ◽  
Heike Bunjes ◽  
Andreas Dietzel
Keyword(s):  
Drug Carrier ◽  
Poorly Soluble Drugs ◽  
Microfluidic Systems ◽  
Routes Of Administration ◽  
Two Photon ◽  
Antisolvent Precipitation ◽  
Stable Production ◽  
Poorly Soluble ◽  
Two Photon Polymerization

Poorly soluble drugs can be incorporated in lipid carrier nanoparticles to achieve sufficient bioavailability and open up diverse routes of administration. Preparation by antisolvent precipitation in microfluidic systems enables excellent...

3D Micromixer

2012 ◽  
Author(s):  
Bahador Farshchian ◽  
Junseo Choi ◽  
Sunggook Park
Keyword(s):  
Cover Plate ◽  
Bottom Surface ◽  
Mixing Efficiency ◽  
Molding Process ◽  
Specific Flow ◽  
Pdms Stamp ◽  
Fluorescein Dye ◽  
Solvent Bonding ◽  
Peeling Off

This paper presents the fabrication of a 3D microchannel whose sidewalls and bottom surface are patterned with ratchets using a modified 3D molding process. In the modified 3D molding process the surface of poly(methyl methacrylate) (PMMA) is first patterned using a brass mold having ratchet structures. Then PDMS prepolymer was spin coated over the surface of micropatterned PMMA and cured followed by the primary molding using a brass mold having a T-conjunction protrusion. After primary molding demolding was done by first demolding the brass mold and then peeling off PDMS stamp from PMMA substrate. By setting a 45° angle between direction of ratchets patterned on the surface of PMMA and the brass mold protrusion prior to primary molding 45° slanted ratchets were formed on the sidewall and bottom surface of microchannel using the modified 3D molding. The scanning electron microscope (SEM) micrographs show a successful integration of micropatterns inside the microchannel. Holes were drilled in the inlet and outlet area of the 3D channel before bonding. A solvent bonding technique was used for bonding of 3D channel to a plain cover plate. After bonding capillary tubes were inserted into the holes and glued to the chip using an epoxy glue. For characterization of mixing fluorescence intensity was quantified in the 3D microchannel as deionized water and fluorescein dye injected from different inlets of 3D micromixer were mixed along the 3D microchannel and mixing efficiency was calculated. The results were compared with the data obtained for similar microdevice whose surfaces were not patterned. The results demonstrate at a specific flow rate a faster mixing occurs in a microdevice whose sidewall and bottom surface are patterned with slanted 45° ratchets.

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