Photoacoustic imaging of RF ablation lesion formation in an ex-vivo passive beating porcine heart model (Conference Presentation)

2019 ◽  
Author(s):  
Sophinese Iskander-Rizk ◽  
Pieter Kruizinga ◽  
Robert Beurskens ◽  
Geert Springeling ◽  
Paul Knops ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Ablation Lesion ◽  
Rf Ablation ◽  
Heart Model ◽  
Lesion Formation ◽  
Porcine Heart

Analysis of myocardial perfusion parameters in an ex-vivo porcine heart model using third generation dual-source CT

2017 ◽  
Vol 11 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Gert Jan Pelgrim ◽  
Taylor M. Duguay ◽  
J. Marco A. Stijnen ◽  
Akos Varga-Szemes ◽  
Sjoerd Van Tuijl ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Ex Vivo ◽  
Third Generation ◽  
Dual Source Ct ◽  
Heart Model ◽  
Porcine Heart ◽  
Dual Source

Relationship Between Ablation Lesion Size Estimated by Ablation Index and Different Ablation Settings—an Ex Vivo Porcine Heart Study

2020 ◽  
Vol 13 (6) ◽  
pp. 965-969
Author(s):  
Shu-Tao Huang ◽  
Jian-Zeng Dong ◽  
Xin Du ◽  
Jia-Hui Wu ◽  
Rong-Hui Yu ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Lesion Size ◽  
Ablation Lesion ◽  
Porcine Heart ◽  
Heart Study ◽  
Ablation Index

scholarly journals Oesophageal thermal protection during AF ablation: effect on left atrial myocardial ablation lesion formation and patient outcomes

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
L Leung ◽  
A El Batran ◽  
G Dhillon ◽  
A Bajpai ◽  
Z Zuberi ◽  
...  
Keyword(s):  
Patient Outcomes ◽  
Left Atrial ◽  
Standard Care ◽  
Thermal Injury ◽  
Ablation Lesion ◽  
Rf Ablation ◽  
Lesion Formation ◽  
Private Company ◽  
Oesophageal Temperature ◽  
Af Ablation

Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Dr Leung has received research support from Attune Medical (Chicago, IL). Dr Gallagher has received research funding from Attune Medical (Chicago, IL). Background Randomized evidence has shown that controlled oesophageal cooling is effective at reducing oesophageal thermal injury during radiofrequency (RF) ablation for atrial fibrillation (AF) compared to standard care. The effect of oesophageal cooling on ablation lesion formation in left atrial myocardium and patient outcomes at 12-months had not been previously studied. Purpose To determine the effect of oesophageal cooling on the formation of RF lesions, the ability to achieve procedural endpoints and long-term patient outcomes compared to standard care ablations. Methods Ablation results and patient outcomes from a double-blind randomized controlled trial were analysed (IMPACT trial NCT03819946). AF ablation was guided by Ablation Index technology (30W at 350-400 AI posteriorly, 40W at 450 AI anteriorly). A blinded 1:1 randomization assigned patients to the use of an oesophageal temperature control device to keep oesophageal temperature at 4 degrees during ablation or standard practice using a single-sensor temperature probe. Ablation parameters and 12-month outcomes were analysed. Results   We recruited 188 patients. Procedure and fluoroscopy times were similar. First pass pulmonary vein isolation and reconnection at the end of the waiting period were similar in both randomized groups (51/64 vs 51/68; p = 0.54 and 5/64 vs 7/68; p = 0.76, respectively). Posterior wall isolation was also similar: 24/33 vs 27/38; p = 0.88. Ablation effect on myocardial tissue, measured in impedance drop, was also similar: 8.6Ω (IQR: 6-11.8) vs 8.76Ω (IQR: 6-12.2; p = 0.25) and median catheter tip temperature was the same at 25.5 degrees. Arrhythmia recurrence was similar at 12 months (20.3% vs 26.8%, from 142 completed assessments; p = 0.66). Conclusions   Oesophageal cooling has been shown to be effective in reducing ablation-related oesophageal thermal injury during RF ablation. Ablation data show that this protection does not make it any more difficult to achieve standard procedural endpoints or clinical success at 12-months. Abstract Figure. Pyramid frequency plots of AI values

Ex vivo porcine heart model for studying cardiac function after cardio pulmonary bypass

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
JM Abicht ◽  
J Jauch ◽  
S Buchholz ◽  
M Thormann ◽  
B Reichart ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Ex Vivo ◽  
Heart Model ◽  
Porcine Heart ◽  
Cardio Pulmonary Bypass ◽  
Pulmonary Bypass

Contact force-sensing catheters: performance in an ex vivo porcine heart model

2018 ◽  
Vol 53 (2) ◽  
pp. 141-150 ◽  
Author(s):  
Eduardo Franco ◽  
Daniel Rodríguez Muñoz ◽  
Roberto Matía ◽  
Antonio Hernández-Madrid ◽  
Inmaculada Sánchez Pérez ◽  
...  
Keyword(s):  
Contact Force ◽  
Ex Vivo ◽  
Force Sensing ◽  
Heart Model ◽  
Porcine Heart

scholarly journals Development of anEx Vivo, Beating Heart Model for CT Myocardial Perfusion

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Gert Jan Pelgrim ◽  
Marco Das ◽  
Ulrike Haberland ◽  
Cees Slump ◽  
Astri Handayani ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Perfusion ◽  
Arterial Pressure ◽  
Ex Vivo ◽  
Ct Perfusion ◽  
Heart Model ◽  
Fractional Flow ◽  
Circumflex Artery ◽  
Porcine Heart ◽  
Flow Reserve

Objective. To test the feasibility of a CT-compatible,ex vivo, perfused porcine heart model for myocardial perfusion CT imaging.Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0.Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9–1.0 L/min, and arterial pressure varied between 80 and 95 mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR ≤ 0.50. Dynamic perfusion scanning was possible across the range of stenosis grades. Perfusion parameters of circumflex-perfused myocardial segments were affected at increasing stenosis grades.Conclusion. An adapted Langendorff porcine heart model is feasible in a CT environment. This model provides control over physiological parameters and may allow in-depth validation of quantitative CT perfusion techniques.

scholarly journals Validation of myocardial perfusion quantification by dynamic CT in an ex-vivo porcine heart model

2017 ◽  
Vol 33 (11) ◽  
pp. 1821-1830 ◽  
Author(s):  
Gert Jan Pelgrim ◽  
Marco Das ◽  
Sjoerd van Tuijl ◽  
Marly van Assen ◽  
Frits W. Prinzen ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Ex Vivo ◽  
Dynamic Ct ◽  
Heart Model ◽  
Porcine Heart ◽  
Perfusion Quantification

Impact of power and contact force on index-guided radiofrequency lesions in an ex vivo porcine heart model

2022 ◽  
Author(s):  
Cristina Lozano Granero ◽  
Eduardo Franco ◽  
Roberto Matía Francés ◽  
Antonio Hernández-Madrid ◽  
Inmaculada Sánchez-Pérez ◽  
...  
Keyword(s):  
Contact Force ◽  
Ex Vivo ◽  
Heart Model ◽  
Porcine Heart ◽  
Radiofrequency Lesions

scholarly journals Towards Transabdominal Functional Photoacoustic Imaging of the Placenta: Improvement in Imaging Depth Through Optimization of Light Delivery

2021 ◽  
Author(s):  
Kristie Huda ◽  
Kenneth F. Swan ◽  
Cecilia T. Gambala ◽  
Gabriella C. Pridjian ◽  
Carolyn L. Bayer
Keyword(s):  
Delivery System ◽  
Light Propagation ◽  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Incidence Angle ◽  
Incident Angle ◽  
Placental Tissue ◽  
Light Delivery ◽  
Imaging Depth ◽  
The Impact

AbstractFunctional photoacoustic imaging of the placenta could provide an innovative tool to diagnose preeclampsia, monitor fetal growth restriction, and determine the developmental impacts of gestational diabetes. However, transabdominal photoacoustic imaging is limited in imaging depth due to the tissue’s scattering and absorption of light. The aim of this paper was to investigate the impact of geometry and wavelength on transabdominal light delivery. Our methods included the development of a multilayer model of the abdominal tissue and simulation of the light propagation using Monte Carlo methods. A bifurcated light source with varying incident angle of light, distance between light beams, and beam area was simulated to analyze the effect of light delivery geometry on the fluence distribution at depth. The impact of wavelength and the effects of variable thicknesses of adipose tissue and muscle were also studied. Our results showed that the beam area plays a major role in improving the delivery of light to deep tissue, in comparison to light incidence angle or distance between the bifurcated fibers. Longer wavelengths, with incident fluence at the maximum permissible exposure limit, also increases fluence within deeper tissue. We validated our simulations using a commercially available light delivery system and ex vivo human placental tissue. Additionally, we compared our optimized light delivery to a commercially available light delivery system, and conclude that our optimized geometry could improve imaging depth more than 1.6×, bringing the imaging depth to within the needed range for transabdominal imaging of the human placenta.

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