In vivo characterization of cyanine dyes as contrast agents for near-infrared imaging

1996 ◽  
Author(s):  
Bjoern Riefke ◽  
Kai Licha ◽  
Wolfhard Semmler ◽  
Dirk Nolte ◽  
Bernd Ebert ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Cyanine Dyes ◽  
Near Infrared Imaging ◽  
In Vivo Characterization

scholarly journals Affibody Molecules for In vivo Characterization of HER2-Positive Tumors by Near-Infrared Imaging

2008 ◽  
Vol 14 (12) ◽  
pp. 3840-3849 ◽  
Author(s):  
Sang Bong Lee ◽  
Moinuddin Hassan ◽  
Robert Fisher ◽  
Oleg Chertov ◽  
Victor Chernomordik ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Imaging ◽  
Near Infrared Imaging ◽  
Her2 Positive ◽  
Affibody Molecules ◽  
In Vivo Characterization

In-vivo characterization of tissue efflux rates of cyanine dyes by near-infrared spectroscopy

1998 ◽  
Author(s):  
Kai Licha ◽  
Vasilis Ntziachristos ◽  
Bjoern Riefke ◽  
Andreas Becker ◽  
Britton Chance ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cyanine Dyes ◽  
In Vivo Characterization

scholarly journals Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles

2018 ◽  
Author(s):  
Wei Chen ◽  
ChiAn Cheng ◽  
Emily Cosco ◽  
Shyam Ramakrishnan ◽  
Jakob Lingg ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Contrast Agents ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
J Aggregates ◽  
Hollow Mesoporous Silica ◽  
Shortwave Infrared

Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-aggregation offers a means to transform stable, near-infrared (NIR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that hollow mesoporous silica nanoparticles (HMSNs) can template the J-aggregation of NIR fluorophore IR-140 to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging <i>in vivo</i>with 980 nm excitation.

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