As the grain size of nano ceramic has reached nanometer grade, it possesses high hardness, high wear resistance and high toughness. Therefore, the scalpel made by nano ceramic has the virtue of high wear resistance, good corrosion resistance, long service life, non-toxic, non-static, sharp edge and so on, but the processing of this kind of scalpel is extremely difficult. This paper prepares the nano-ceramic scalpel by using ELID grinding technology, and also studies the thickness, surface roughness, edge sharpness of scalpel. The research results show that the thickness of prepared scalpel is 0.3 mm, the surface roughness is 6-60 nm and the edge radius is 200 nm, the cutting experiment on suture shows that this scalpel can meet the requirements of international standard for medical scalpel when the cutting force is less than 0.8 N. This further proves that the ELID grinding technology is suitable for the preparation of nano-ceramic scalpel. The preparation technology and technological equipment of nano-ceramic scalpel are proposed on the basis of above achievements, and this technology possesses promising application prospect.