Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy

2011 ◽  
Vol 39 (1) ◽  
pp. 237-245 ◽  
Author(s):  
Quentin Diot ◽  
Brian Kavanagh ◽  
Robert Timmerman ◽  
Moyed Miften
Keyword(s):  
Radiation Therapy ◽  
Stereotactic Body Radiation Therapy ◽  
Volumetric Modulated Arc Therapy ◽  
Stereotactic Body Radiation ◽  
Arc Therapy ◽  
Therapy Delivery

scholarly journals Dosimetric Comparison of Real-Time MRI-Guided Tri-Cobalt-60 Versus Linear Accelerator-Based Stereotactic Body Radiation Therapy Lung Cancer Plans

2017 ◽  
Vol 16 (3) ◽  
pp. 366-372 ◽  
Author(s):  
Andrzej P. Wojcieszynski ◽  
Patrick M. Hill ◽  
Stephen A. Rosenberg ◽  
Craig R. Hullett ◽  
Zacariah E. Labby ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Lung Cancer ◽  
Radiation Therapy ◽  
Magnetic Resonance ◽  
Tumor Volume ◽  
Stereotactic Body Radiation Therapy ◽  
Volumetric Modulated Arc Therapy ◽  
Resonance Imaging ◽  
Stereotactic Body Radiation ◽  
Arc Therapy

Purpose: Magnetic resonance imaging–guided radiation therapy has entered clinical practice at several major treatment centers. Treatment of early-stage non-small cell lung cancer with stereotactic body radiation therapy is one potential application of this modality, as some form of respiratory motion management is important to address. We hypothesize that magnetic resonance imaging–guided tri-cobalt-60 radiation therapy can be used to generate clinically acceptable stereotactic body radiation therapy treatment plans. Here, we report on a dosimetric comparison between magnetic resonance imaging–guided radiation therapy plans and internal target volume–based plans utilizing volumetric-modulated arc therapy. Materials and Methods: Ten patients with early-stage non-small cell lung cancer who underwent radiation therapy planning and treatment were studied. Following 4-dimensional computed tomography, patient images were used to generate clinically deliverable plans. For volumetric-modulated arc therapy plans, the planning tumor volume was defined as an internal target volume + 0.5 cm. For magnetic resonance imaging–guided plans, a single mid-inspiratory cycle was used to define a gross tumor volume, then expanded 0.3 cm to the planning tumor volume. Treatment plan parameters were compared. Results: Planning tumor volumes trended larger for volumetric-modulated arc therapy–based plans, with a mean planning tumor volume of 47.4 mL versus 24.8 mL for magnetic resonance imaging–guided plans ( P = .08). Clinically acceptable plans were achievable via both methods, with bilateral lung V20, 3.9% versus 4.8% ( P = .62). The volume of chest wall receiving greater than 30 Gy was also similar, 22.1 versus 19.8 mL ( P = .78), as were all other parameters commonly used for lung stereotactic body radiation therapy. The ratio of the 50% isodose volume to planning tumor volume was lower in volumetric-modulated arc therapy plans, 4.19 versus 10.0 ( P < .001). Heterogeneity index was comparable between plans, 1.25 versus 1.25 ( P = .98). Conclusion: Magnetic resonance imaging–guided tri-cobalt-60 radiation therapy is capable of delivering lung high-quality stereotactic body radiation therapy plans that are clinically acceptable as compared to volumetric-modulated arc therapy–based plans. Real-time magnetic resonance imaging provides the unique capacity to directly observe tumor motion during treatment for purposes of motion management.

VOLUMETRIC MODULATED ARC THERAPY IN STEREOTACTIC BODY RADIATION THERAPY FOR METASTASES TO ABDOMINAL LYMPH-NO) DES

2009 ◽  
Vol 92 ◽  
pp. S198
Author(s):  
M. Bignardi ◽  
L. Cozzi ◽  
A. Fogliata Cozzi ◽  
P. Lattuada ◽  
P. Mancosu ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Stereotactic Body Radiation Therapy ◽  
Volumetric Modulated Arc Therapy ◽  
Stereotactic Body Radiation ◽  
Arc Therapy

VMAT Stereotactic Body Radiation Therapy in a Multimodal Approach to a Carotid Paraganglioma in a Dog

2018 ◽  
Vol 54 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Mario Dolera ◽  
Nancy Carrara ◽  
Luca Malfassi
Keyword(s):  
Radiation Therapy ◽  
Carotid Body ◽  
Stereotactic Body Radiation Therapy ◽  
Volumetric Modulated Arc Therapy ◽  
Cervical Region ◽  
Stereotactic Body Radiation ◽  
Arc Therapy ◽  
Mri Scans ◽  
Single Mass ◽  
Set Up

ABSTRACT A 7 yr old female pit bull terrier was presented for a cervical soft tissue swelling located in the left jugular region. No abnormalities were present at physical examination or in the laboratory workup. Computed tomography and MRI scans showed a well-defined, ovoid, single mass in the left dorsal cervical region connected to the common carotid artery, histologically consistent with carotid body paraganglioma. The mass was surgically resected. Frameless stereotactic body radiation therapy with volumetric modulated arc therapy was set up as adjuvant treatment. After radiation therapy, systemic chemotherapy with carboplatin was started. During the first yr of follow-up, acute grade I dermatitis and grade I left-side laryngeal mucositis were recognized. One yr after radiation therapy, no signs of late radiotoxicity or tumor recurrence were observed. Grade I thrombocytopenia concurrent with chemotherapy was observed. This is the first reported case of a carotid body paraganglioma treated by multimodal therapy, with surgical resection and adjuvant radiotherapy and chemotherapy. Stereotactic body radiation therapy with volumetric modulated arc therapy treatment after surgery provided excellent disease control and was well tolerated with slight side effects.

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