SU-E-T-288: Dose Volume Population Histogram (DVPH): A New Method to Evaluate Intensity Modulated Proton Therapy Plans With Geometrical Uncertainties

Nowadays, traditional radiation therapy using x-rays is still the most common type of external exposure in curing cancer. However, the persisting problem is that significant dose delivered to normal tissues because of the characteristics of interaction of photons with matter even with the most advanced delivery techniques such as IMRT, IGRT, etc. Proton therapy is not only the technique producing better conformity to target but also better sparing to organs at risk. In this work, intensity modulated proton therapy (IMPT) and intensity modulated photon therapy (IMRT) plans are generated for a prostate patient. The evaluation and comparison of the two treatment plans were performed in term of physical quantity based on Dose Volume Histogram (DVH) and dose statistics for both target and organs at risk. The results of our study show that IMPT could be beneficial compared to IMRT with 5 fields. The doses to intestine and bladder are low resulting in possibly reducing side effects and second malignancies

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Robustness evaluation of Intensity Modulated Proton Therapy plans using Dose Volume Population Histogram

Physica Medica ◽

10.1016/j.ejmp.2019.09.070 ◽

2019 ◽

Vol 65 ◽

pp. 219-226

Author(s):

Thu T.C. Nguyen ◽

Binh T. Nguyen ◽

Nhon V. Mai

Keyword(s):

Proton Therapy ◽

Intensity Modulated Proton Therapy ◽

Intensity Modulated ◽

Dose Volume

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Mixed integer programming with dose‐volume constraints in intensity‐modulated proton therapy

Journal of Applied Clinical Medical Physics ◽

10.1002/acm2.12130 ◽

2017 ◽

Vol 18 (5) ◽

pp. 29-35 ◽

Cited By ~ 2

Author(s):

Pengfei Zhang ◽

Neng Fan ◽

Jie Shan ◽

Steven E. Schild ◽

Martin Bues ◽

...

Keyword(s):

Integer Programming ◽

Mixed Integer Programming ◽

Proton Therapy ◽

Mixed Integer ◽

Intensity Modulated Proton Therapy ◽

Intensity Modulated ◽

Dose Volume

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Early Clinical Outcomes of Intensity Modulated Radiation Therapy/Intensity Modulated Proton Therapy Combination in Comparison with Intensity Modulated Radiation Therapy Alone in Oropharynx Cancer Patients

Cancers ◽

10.3390/cancers13071549 ◽

2021 ◽

Vol 13 (7) ◽

pp. 1549

Author(s):

Han Gyul Yoon ◽

Yong Chan Ahn ◽

Dongryul Oh ◽

Jae Myoung Noh ◽

Seung Gyu Park ◽

...

Keyword(s):

Radiation Therapy ◽

Proton Therapy ◽

Intensity Modulated Radiation Therapy ◽

Combination Group ◽

Intensity Modulated Proton Therapy ◽

Oropharynx Cancer ◽

Intensity Modulated ◽

Before And After ◽

Grade 3 ◽

Early Clinical Outcomes

Purpose: To report the early clinical outcomes of combining intensity-modulated radiation therapy (IMRT) and intensity-modulated proton therapy (IMPT) in comparison with IMRT alone in treating oropharynx cancer (OPC) patients. Materials and Methods: The medical records of 148 OPC patients who underwent definitive radiotherapy (RT) with concurrent systemic therapy, from January 2016 till December 2019 at Samsung Medical Center, were retrospectively reviewed. During the 5.5 weeks’ RT course, the initial 16 (or 18) fractions were delivered by IMRT in all patients, and the subsequent 12 (or 10) fractions were either by IMRT in 81 patients (IMRT only) or by IMPT in 67 (IMRT/IMPT combination), respectively, based on comparison of adaptive re-plan profiles and availability of equipment. Propensity-score matching (PSM) was done on 76 patients (38 from each group) for comparative analyses. Results: With the median follow-up of 24.7 months, there was no significant difference in overall survival and progression free survival between groups, both before and after PSM. Before PSM, the IMRT/IMPT combination group experienced grade ≥ 3 acute toxicities less frequently: mucositis in 37.0% and 13.4% (p < 0.001); and analgesic quantification algorithm (AQA) in 37.0% and 19.4% (p = 0.019), respectively. The same trends were observed after PSM: mucositis in 39.5% and 15.8% (p = 0.021); and AQA in 47.4% and 21.1% (p = 0.016), respectively. In multivariate logistic regression, grade ≥ 3 mucositis was significantly less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.027 and 0.024, respectively). AQA score ≥ 3 was also less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.085 and 0.018, respectively). Conclusions: In treating the OPC patients, with comparable early oncologic outcomes, more favorable acute toxicity profiles were achieved following IMRT/IMPT combination than IMRT alone.

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